Abstract
Malaria continues to be a significant public health burden in many tropical and subtropical regions. Mozambique ranks among the top countries affected by malaria, where it is a leading cause of morbidity and mortality, accounting for 29% of all hospital deaths in the general population and 42% o...
As malaria elimination becomes a possibility the focus of interventions changes from vector control to disease control. It is important that treatment occurs early during an infection in order for it to be efficacious, especially at the population level. The time between the onset of symptoms and treatme...
Mayor, Alfredo;
Silva, Clemente;
Valbona, Eduard Rovira;
Feltrer, Arantxa Roca;
Bonnington, Craig;
Smith, Alexandra Wharton;
Greehouse, Bryan;
Bever, Caitlin;
Chidimatembue, Arlindo;
Guinovart, Caterina;
Proctor, Joshua L;
Rodrigues, Maria;
Canana, Neide;
Arnaldo, Paulo;
Boene, Simone;
Enosse, Sonia;
Saute, Francisco;
Candrinho, Baltazar.
Introduction: Genomic data constitute a valuable adjunct to routine surveillance that can guide programmatic decisions to reduce the burden of infectious diseases. However, genomic capacities remain low in Africa. This study aims to operationalise a functional malaria molecular surveillance system in Moz...
Background: Due to the threat of emerging anti-malarial resistance, the World Health Organization recommends incorporating surveillance for molecular markers of anti-malarial resistance into routine therapeutic efficacy studies (TESs). In 2018, a TES of artemether-lumefantrine (AL) and artesunate-amodiaq...
Antimaláricos/farmacologia,
Antimaláricos/uso terapêutico,
Artemisininas/farmacologia,
Artemisininas/uso terapêutico,
Resistência a Medicamentos/genética,
Quimioterapia Combinada,
Marcadores Genéticos,
Plasmodium falciparum/efeitos da radiação,
Plasmodium falciparum/genética,
Plasmodium falciparum/isolamento & purificação,
Polimorfismo Genético/genética,
Moçambique
Moraleda, Cinta;
Aguilar, Ruth;
Quintó, Llorenç;
Nhampossa, Tacilta;
Renom, Montserrat;
Nhabomba, Augusto;
Ruperez, María;
Aponte, John J;
Achtman, Ariel H;
Mañú Pereira, María Del Mar;
Schofield, Louis;
lonso, Pedro L;
Macete, Eusebio;
Menéndez, Clara.
AnemiaisacommonconditioninHIV-infectedchildren;however,itspathophysiology andthecontribution
of frequent causes of anemia such as iron deficiency (ID) and malaria are poorly understood. We carried out an ancillary
studyontheeffectofHIVonanemiaaspartofacase–controlstudyonriskfactorsofanemiaamongMozamb...
Introdução: Moçambique é um dos países endémicos à malária. Em 2011, a estimativa de prevalência desta doença era de 40–80% em crianças dos 2–9 anos e 90% em crianças menores de 5 anos. Estas altas prevalências podem ser devido à dificuldade das crianças em desenvolverem uma resposta i...
Galatas, Beatriz;
Mayor, Alfredo;
Gupta, Himanshu;
Balanza, Núria;
Jang, Ihn Kyung;
Nhamussua, Lidia;
Simone, Wilson;
Cistero, Pau;
Chidimatembue, Arlindo;
Munguambe, Humberto;
Saute, Francisco;
Aide, Pedro;
Bassat, Quique.
An ultrasensitive malaria rapid diagnostic test (RDT) was recently developed for the improved detection of low-density Plasmodium falciparum infections. This study aimed to compare the diagnostic performance of the PfHRP2-based Abbott Malaria Ag P. falciparum ultrasensitive RDT (uRDT) to that of the conv...
Antígenos de Protozoários/genética,
Parasitologia/métodos,
d0077700,
d0126800,
Moçambique,
Antígenos de Protozoários/sangue,
Estudos Transversais,
Teste em Amostras de Sangue Seco/métodos,
Teste em Amostras de Sangue Seco/estatística & dados numéricos,
Malária Falciparum/diagnóstico,
Parasitologia/estatística & dados numéricos,
Plasmodium falciparum/genética
Gupta, himanshu;
Bassat, quique;
Nhamussua, lidia;
Matambisso, gloria;
Cisteró, pau;
Huijben, silvie;
Chidimatembue, arlindo;
Galatas, beatriz;
Ménard, didier;
Ringwald, pascal;
Rabinovich, regina;
Alonso, pedro L;
Saute, francisco;
Assessor, pedro;
Prefeito, alfredo.
Background Mass drug administration (MDA) can rapidly reduce the burden of Plasmodium falciparum (Pf). However, concerns remain about its contribution to select for antimalarial drug resistance. Methods We used Sanger sequencing and real-time PCR to determine the proportion of molecular markers associate...
Antimaláricos/administração & dosagem,
Antimaláricos/farmacologia,
Antimaláricos/uso terapêutico,
Artemisininas/administração & dosagem,
Artemisininas/farmacologia,
Artemisininas/uso terapêutico,
Protocolos de Quimioterapia Combinada Antineoplásica,
Resistência a Medicamentos/genética,
Malária/parasitologia,
Malária/prevenção & controle,
Moçambique,
Plasmodium falciparum/imunologia,
Plasmodium falciparum/genética,
Plasmodium falciparum/patogenicidade,
Polimorfismo Genético,
Proteínas de Protozoários/genética,
Proteínas de Protozoários/metabolismo,
Quinolinas/administração & dosagem,
Quinolinas/uso terapêutico,
Quinolinas/farmacologia
Gupta, himanshu;
Galatas, beatriz;
Matambisso, gloria;
Nhamussua, lidia;
Cisteró, pau;
Bassat, quique;
Casellas, aina;
Macete, eusebio;
Aponte, john, j;
Sacoor, charfudin;
Alonso, pedro;
Saúte, francisco;
Guinovart, caterina;
Aide, pedro;
Mayor, alfredo.
Background: Poor knowledge on the afebrile Plasmodium falciparum biology limits elimination approaches to target asymptomatic malaria. Therefore, the association of parasite factors involved in cytoadhesion, parasite multiplication and gametocyte maturation with afebrile malaria was assessed.
Methods: Pl...
Women attending antenatal care (ANC) are a generally healthy, easy-access population, contributing valuable data for infectious disease surveillance at the community level. ANC-based malaria surveillance would provide a routine measure of the malaria burden in pregnancy, which countries lack, whilst pote...
