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Efficacy and safety of dihydroartemisinin-piperaquine for treatment of Plasmodium falciparum uncomplicated malaria in adult patients on antiretroviral therapy in Malawi and Mozambique: an open label non-randomized interventional trial

Sevene, esperança; Banda, clifford G; Mukaka, mavuto; Maculuve, sonia; Vala, anifa; Macuacua, salésio; Piqueras, mireia; Phiri, linda kalilani; Mallewa, jane; Terlouw, dianne J; Khoo, saye H; Lalloo, david G; Mwapasa, victor.
Malar. j. (Online); 18 (1), 2019
Background: HIV-infected individuals on antiretroviral therapy (ART) require treatment with artemisinin-based combination therapy (ACT) when infected with malaria. Dihydroartemisinin–piperaquine (DPQ) is recommended for treatment of Plasmodium falciparum malaria, but its efcacy and safety has not been ...
Artemisininas/efeitos adversos, Antimaláricos/efeitos adversos, Antirretrovirais/uso terapêutico, Benzoxazinas/uso terapêutico, Ciclopropanos, Malária Falciparum/prevenção & controle, Moçambique, Nevirapina/uso terapêutico, Plasmodium falciparum/fisiologia
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Placental Microparticles and MicroRNAs in Pregnant Women with Plasmodium falciparum or HIV Infection

Moro, Laura; Bardaji, Azucena; Macete, Eusebio; Barrios, Diana; Prieto, Diana M Morales; Espana, Carolina; Mandomando, Inacio; Sigauque, Betuel; Dobano, Carlota; Markert, Udo R; Ribas, Daniel Benitez; Alonso, Pedro L; Menendez, Clara; Mayor, Alfredo.
PLos ONE; 11 (1), 2016
During pregnancy, syncytiotrophoblast vesicles contribute to maternal tolerance towards the fetus, but also to pathologies such as pre-eclampsia. The aim of the study was to address whether Plasmodium falciparum and HIV infections in pregnancy affect the secretion, microRNA content and function of tropho...
Malária Falciparum/patologia, Malária Falciparum/metabolismo, Placenta/metabolismo, Resultado da Gravidez, Micropartículas Derivadas de Células/metabolismo, Micropartículas Derivadas de Células/ultraestrutura, Quimiocinas/metabolismo, Células Dendríticas/metabolismo, Demografia/estatística & dados numéricos, Recém-Nascido, MicroRNAs/metabolismo, Plasmodium falciparum/fisiologia, Trofoblastos/metabolismo, Moçambique
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