RDSM – Rede de Documentação sobre Saúde em Moçambique

Molecular surveillance for polymorphisms associated with artemisinin-based combination therapy resistance in Plasmodium falciparum isolates collected in Mozambique, 2018

Chidimatembue, arlindo; Svigel, samaly s.

Malar. j. (Online); 20 (1), 2021

Background: Due to the threat of emerging anti-malarial resistance, the World Health Organization recommends incorporating surveillance for molecular markers of anti-malarial resistance into routine therapeutic efficacy studies (TESs). In 2018, a TES of artemether-lumefantrine (AL) and artesunate-amodiaq...

Antimaláricos/farmacologia, Antimaláricos/uso terapêutico, Artemisininas/farmacologia, Artemisininas/uso terapêutico, Resistência a Medicamentos/genética, Quimioterapia Combinada, Marcadores Genéticos, Plasmodium falciparum/efeitos da radiação, Plasmodium falciparum/genética, Plasmodium falciparum/isolamento & purificação, Polimorfismo Genético/genética, Moçambique

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Drug-resistant polymorphisms and copy numbers in plasmodium falciparum, mozambique, 2015

One of the fundamental steps toward malaria control is the use of antimalarial drugs. The success of antimalarial treatment can be affected by the presence of drug-resistant populations of Plasmodium falciparum. To assess resistance, we used molecular methods to examine 351 P. falciparum isolates collect...