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Evaluation of the safety and efficacy of dihydroartemisinin-piperaquine for intermittent preventive treatment of malaria in HIV-infected pregnant women: protocol of a multicentre, two-arm, randomised, placebo-controlled, superiority clinical trial (MAMAH project)

González, raquel; Nhampossa, tacilta 3; Ngoma, ghyslain mombo; Mischlinger, johannes; Esen, meral; Tchouatieu, andré marie; Duran, clara pons; Dimessa, lia betty; Lell, bertrand; Lagler, heimo; Otero, laura garcia.
BMJ Open; 11 (11), 2021
Introduction: Malaria infection during pregnancy is an important driver of maternal and neonatal health especially among HIV-infected women. Intermittent preventive treatment in pregnancy (IPTp) with sulphadoxine-pyrimethamine is recommended for malaria prevention in HIV-uninfected women, but it is contr...
Antimaláricos/efeitos adversos, Artemisininas, Artesunato/administração & dosagem, Infecções por HIV/prevenção & controle, Transmissão Vertical de Doenças Infecciosas/prevenção & controle, Malária/prevenção & controle, Moçambique/epidemiologia, Complicações Parasitárias na Gravidez/induzido quimicamente, Complicações Parasitárias na Gravidez/prevenção & controle, Quinolinas
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Effect of mass dihydroartemisinin-piperaquine administration in southern Mozambique on the carriage of molecular markers of antimalarial resistance

Gupta, himanshu; Bassat, quique; Nhamussua, lidia; Matambisso, gloria; Cisteró, pau; Huijben, silvie; Chidimatembue, arlindo; Galatas, beatriz; Ménard, didier; Ringwald, pascal; Rabinovich, regina; Alonso, pedro L; Saute, francisco; Assessor, pedro; Prefeito, alfredo.
PLos ONE; 15 (10), 2020
Background Mass drug administration (MDA) can rapidly reduce the burden of Plasmodium falciparum (Pf). However, concerns remain about its contribution to select for antimalarial drug resistance. Methods We used Sanger sequencing and real-time PCR to determine the proportion of molecular markers associate...
Antimaláricos/administração & dosagem, Antimaláricos/farmacologia, Antimaláricos/uso terapêutico, Artemisininas/administração & dosagem, Artemisininas/farmacologia, Artemisininas/uso terapêutico, Protocolos de Quimioterapia Combinada Antineoplásica, Resistência a Medicamentos/genética, Malária/parasitologia, Malária/prevenção & controle, Moçambique, Plasmodium falciparum/imunologia, Plasmodium falciparum/genética, Plasmodium falciparum/patogenicidade, Polimorfismo Genético, Proteínas de Protozoários/genética, Proteínas de Protozoários/metabolismo, Quinolinas/administração & dosagem, Quinolinas/uso terapêutico, Quinolinas/farmacologia
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Treatment outcomes in a safety observational study of dihydroartemisinin/piperaquine (Eurartesim(®)) in the treatment of uncomplicated malaria at public health facilities in four African countries

Adjei, aexander; Bana, solomon narh; Amu, alberta; Kukula, vida; Nagai, richard afedi; Agyei, seth owusu; Oduro, abraham; Macete, Eusebio; Abdulla, salim; Halidou, tinto; Sie, ali; Osei, isaac; Sevene, esperance; Asante, kwaku-poku; Mulokozi, abdunoor; Compaore, guillaume; Valea, innocent; Adjuik, martin; Baiden, rita; Ogutu, Bernhards; Binka, fred; Gyapong, margaret.
Malar. j. (Online); 15 (43), 2016
Background: Dihydroartemisinin-piperaquine (DHA-PQ) is one of five WHO recommended artemisinin combination therapy (ACT) for the treatment of uncomplicated malaria. However, little was known on its post-registration safety and effectiveness in sub-Saharan Africa. DHA-PQ provides a long post-treatment pro...
Antimaláricos/uso terapêutico, Artemisininas/uso terapêutico, Burkina Faso, Malária/tratamento farmacológico, Quinolinas/uso terapêutico, Instalações de Saúde/estatística & dados numéricos, Estudos Longitudinais, Gana, Moçambique, Tanzânia
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