RDSM – Rede de Documentação sobre Saúde em Moçambique

Reduced Placental Transfer of Antibodies Against a Wide Range of Microbial and Vaccine Antigens in HIV-Infected Women in Mozambique

Alonso, Selena; Vudal, Marta; Olalla, Gemma Ruiz; Gonzelez, Raquel; Manaca, M Nelia; Jairoce, Chenjerai; Balcells, Reyes; Vala, Anifa; Ruperez, María; Soro, Laura Fuente; Cova, Marta; Angov, Evelina; Nhacolo, Arsenio; Sevene, Esperança; Aponte, John J; Macete, Eusebio; Dobano, Carlota; Moncunil, Gemma.

Front. immunol; 12 (), 2021

Transplacental transfer of antibodies is essential for conferring protection in newborns against infectious diseases. We assessed the impact of different factors, including gestational age and maternal infections such as HIV and malaria, on the efficiency of cord blood levels and placental transfer of Ig...

Anticorpos/imunologia, Antígenos/imunologia, Terapia Antirretroviral de Alta Atividade, Sangue Fetal/imunologia, Infecções por HIV/terapia, Infecções por HIV/epidemiologia, Infecções por HIV/imunologia, Infecções por HIV/virologia, Imunidade Materno-Adquirida, Imunoglobulina G/imunologia, Troca Materno-Fetal/imunologia, Placenta/metabolismo, Gravidez, Proteínas de Transporte, Fatores Sexuais, Vacinas/imunologia

Texto completo

Malaria and HIV infection in Mozambican pregnant women are associated with reduced transfer of antimalarial antibodies to their newborns

Background. Malaria and human immunodeficiency virus (HIV) during pregnancy affect the transplacental transfer of antibodies against several pathogens from mother to fetus, although their effect over antimalarial antibodies remains unclear. Methods. Total immunoglobulin G (IgG), IgM and IgG subtypes aga...