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Escalation of Pyrethroid Resistance in the Malaria Vector Anopheles funestus Induces a Loss of Efficacy of Piperonyl Butoxide–Based Insecticide-Treated Nets in Mozambique

Riveron, Jacob M; Huijben, Silvie; Tchapga, Williams; Tchouakui, Magellan; Wondji, Murielle J; Tchoupo, Micareme; Irving, Helen; Cuamba, Nelson; Maquina, Mara; Paaijmans, Krijn; Wondji, Charles S.
The Journal of Infectious Diseases; 220 (3), 2019
Insecticide resistance poses a serious threat to insecticide-based interventions in Africa. There is a fear that resistance escalation could jeopardize malaria control efforts. Monitoring of cases of aggravation of resistance intensity and its impact on the efficacy of control tools is crucial to predict...
Butóxido de Piperonila/farmacologia, Resistência a Inseticidas/genética, Malária/transmissão, Mosquitos Vetores/efeitos dos fármacos, Piretrinas/farmacologia, Anopheles, Sistema Enzimático do Citocromo P-450/genética, Mosquiteiros Tratados com Inseticida, Moçambique, Inseticidas/farmacologia
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Frequencies of Cytochrome P450 2B6 and 2C8 Allelic Variants in the Mozambican Population

Arnaldo, Paulo; Thompson, Ricardo Estevão; Lopes, Márcia Quinhones; Suffys, Philip Noe; Santos, Adalberto Rezende.
Frequencies of Cytochrome P450 2B6 and 2C8 Allelic Variants in the Mozambican Po; 20(4) (), 2012
Background: The cytochrome P450 enzymes (CYP) play an important role in the metabolism of many therapeutic agents. The activities of different enzymes exhibit variability in different populations, which causes variations in drug response or toxicity. The CYP2B6 and CYP2C8 enzymes are encoded by polymorph...
Isoenzimas, Sistema Enzimático do Citocromo P-450, d0657020, Citocromo P-450 CYP2C8, Polimorfismo de Nucleotídeo Único, Polimorfismo de Fragmento de Restrição, Enzimas, Terapêutica, Antimaláricos, Doadores de Sangue, Genes
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