Pneumococcal pneumonia is the leading infectious cause of childhood mortality with an estimated 257 000 deaths globally among children aged 1–59 months in 2015 [1, 2]. Streptococcus pneumoniae is the most common cause of bacterial pneumonia in children [3]. HIV-infected children are at increased risk ...
Background: Dried blood spots (DBS) have been proposed as potentially tool for detecting invasive bacterial diseases. Methods: We evaluated the use of DBS for S. pneumoniae and H. influenzae detection among children in Mozambique. Blood for DBS and nasopharyngeal (NP) swabs were collected from children w...
Streptococcus pneumoniae (pneumococcus) is a major cause of disease in children, and is associated with high morbidity and mortality worldwide [1]. In 2015, invasive pneumococcal disease (IPD) was responsible for an estimated 318,000 deaths in children under 5 years of age, with most of these deaths occu...
Nasopharyngeal carriage is a precursor for pneumococcal disease and can be useful for evaluating pneumococcal conjugate vaccine (PCV) impact. We studied pre-PCV pneumococcal carriage among HIV-infected and -uninfected children in Mozambique. Between October 2012 and March 2013, we enrolled HIV-infected c...
Background: S. pneumoniae is the leading cause of acute bacterial meningitis (ABM) in children. Vaccination using the 10-valent conjugate vaccine (PCV-10) was recently introduced into the National Immunization Program in Mozambique, but data on serotype coverage of this vaccine formulation are scarce. In...
Background: In Sub-Saharan Africa, including Mozambique, acute bacterial meningitis (ABM) represents a main cause of childhood mortality. The burden of ABM is seriously underestimated because of the poor performance of culture sampling, the primary method of ABM surveillance in the region. Low quality ce...
Background: In Sub-Saharan Africa, including Mozambique, acute bacterial meningitis (ABM) represents a main cause of childhood mortality. The burden of ABM is seriously underestimated because of the poor performance of culture sampling, the primary method of ABM surveillance in the region. Low quality ce...
