Viegas, Edna O;
Arne, Kroidl;
Munseri, Patricia J;
Missanga, Marco;
Nilsson, Charlotta;
Tembe, Nelson;
Bauer, Asli;
Joachin, Agricola;
Joseph, Sarah;
Mann, Philipp;
Geldmacher, Christof;
Fleck, Sue;
Stöhr, Wolfgang;
Scarlatti, Gabriella;
Aboud, Said;
Bakari, Muhammad;
Maboko, Leonard;
Hoelscher, Michael;
Wahren, Britta;
Robb, Merlin L;
Weber, Jonathan;
McCormack, Sheena;
Biberfeld, Gunnel;
Jani, Ilesh V;
Sandström, Eric;
Lyamuya, Eligius.
Background: We evaluated the safety and immunogenicity of (i) an intradermal HIV-DNA regimen given with/without intradermal electroporation (EP) as prime and (ii) the impact of boosting with modified vaccinia virus Ankara (HIV-MVA) administered with or without subtype C CN54rgp140 envelope protein adjuva...
Adulto Jovem,
Vacinas Virais,
Alergia e Imunologia,
Genética,
Vacinas de DNA,
Vacinação,
Tanzânia/epidemiologia,
Moçambique/epidemiologia,
Humanos,
Voluntários Saudáveis,
Eletroporação,
Anticorpos Neutralizantes,
Adulto,
Administração Cutânea,
Vacinas contra a AIDS
Viegas, Edna O;
Kroidl, Arne;
Munser, Patricia J;
Missanga, Marco;
Nilsson, Charlotta;
Tembe, Nelson;
Bauer, Asli;
Joachim, Agricola;
Joseph, Sarah;
Mann, Philipp;
Geldmache, Christof;
Fleck, Sue;
Stohr, Wolfgang;
Scarlatti, Gabriella.
Although there has been a decline in the number of new human immunodeficiency virus (HIV) infections over the years, millions of people continue to be exposed and infected [1]. More than 200 HIV vaccine phase I and II, and 6 efficacy trials have been conducted [2, 3]. The RV144 Thai trial is the only tri...
Background: Health systems are essential platforms for accessible, quality health services, and population health improvements. Global health initiatives have dramatically increased health resources; however, funding to strengthen health systems has not increased commensurately, partially due to concern...
Background: Achieving the United Nations Sustainable Development Goals in sub-Saharan Africa will require substantial improvements in the coverage and performance of primary health care delivery systems. Projects supported by the Doris Duke Charitable Foundation's (DDCF) African Health Initiative (AHI) c...
Background: Despite global efforts to increase health workforce capacity through training and guidelines, challenges remain in bridging the gap between knowledge and quality clinical practice and addressing health system deficiencies preventing health workers from providing high quality care. In many dev...
Adjei, aexander;
Bana, solomon narh;
Amu, alberta;
Kukula, vida;
Nagai, richard afedi;
Agyei, seth owusu;
Oduro, abraham;
Macete, Eusebio;
Abdulla, salim;
Halidou, tinto;
Sie, ali;
Osei, isaac;
Sevene, esperance;
Asante, kwaku-poku;
Mulokozi, abdunoor;
Compaore, guillaume;
Valea, innocent;
Adjuik, martin;
Baiden, rita;
Ogutu, Bernhards;
Binka, fred;
Gyapong, margaret.
Background: Dihydroartemisinin-piperaquine (DHA-PQ) is one of five WHO recommended artemisinin combination therapy (ACT) for the treatment of uncomplicated malaria. However, little was known on its post-registration safety and effectiveness in sub-Saharan Africa. DHA-PQ provides a long post-treatment pro...
González, Raquel;
Desai, Meghna;
Macete 3, Eusebio;
Ouma, Peter;
Kakolwa, Mwaka A;
Abdulla, Salim;
Aponte, John J;
Bulo, Helder;
Kabanywanyi, Abdunoor M;
Katana, Abraham;
Maculuve, Sonia;
Mayor, Alfredo;
Nhacolo, Arsenio;
Otieno, Kephas;
Pahlavan, Golbahar;
Rupérez, María;
Sevene, Esperança;
Slutsker, Laurence;
Vala, Anifa;
Williamsom, John;
Menéndez, Clara.
Background: Intermittent preventive treatment in pregnancy (IPTp) with sulfadoxine-pyrimethamine (SP) is recommended for malaria prevention in HIV-negative pregnant women, but it is contraindicated in HIV-infected women taking daily cotrimoxazole prophylaxis (CTXp) because of potential added risk of adve...
Antimaláricos/administração & dosagem,
Método Duplo-Cego,
Seguimentos,
Infecções por HIV/diagnóstico,
Infecções por HIV/tratamento farmacológico,
Infecções por HIV/epidemiologia,
Transmissão Vertical de Doenças Infecciosas/prevenção & controle,
Malária/diagnóstico,
Malária/epidemiologia,
Malária/prevenção & controle,
Mefloquina/administração & dosagem,
Complicações Infecciosas na Gravidez/diagnóstico,
Complicações Infecciosas na Gravidez/epidemiologia,
Complicações Infecciosas na Gravidez/prevenção & controle,
Complicações Parasitárias na Gravidez/diagnóstico,
Complicações Parasitárias na Gravidez/epidemiologia,
Complicações Parasitárias na Gravidez/prevenção & controle,
Resultado da Gravidez,
Moçambique/epidemiologia,
Tanzânia/epidemiologia,
Quênia/epidemiologia,
Combinação Trimetoprima e Sulfametoxazol/administração & dosagem
Task-shifting of major surgery to midlevel providers of health care in Mozambique and Tanzania - a solution to the crisis in human resources to enhance maternal and neonatal survival Background: Task-shifting, using non-physician clinicians (NPCs) to perform major surgery in obstetric emergencies 1s comm...
Atenção à Saúde,
Cesárea,
Categorias de Trabalhadores,
Emergências,
Cirurgia Geral,
Gastos em Saúde,
Faculdades de Medicina,
Gravidez Ectópica,
Mães,
Procedimentos Cirúrgicos Obstétricos,
Terapêutica,
Moçambique,
Tanzânia,
Recursos Humanos
Background
Naturally acquired malaria immunity has many determinants and, in the absence of immunological markers of protection, studies assessing malaria incidence through clinical endpoints remain an approach to defining immunity acquisition. We investigated the role of age in disease incidence and th...
Fatores Etários,
Anemia,
Antígenos de Protozoários/imunologia,
Anemia/prevenção & controle,
Anemia/imunologia,
Dapsona/uso terapêutico,
Quimioterapia Combinada,
Malária Falciparum/imunologia,
Malária Falciparum/prevenção & controle,
Malária Falciparum/epidemiologia,
Plasmodium falciparum/imunologia,
Plasmodium falciparum/efeitos dos fármacos,
Tanzânia/epidemiologia,
Pirimetamina/uso terapêutico,
Resultado do Tratamento
Background: The observation of an increased prevalence of allergic disorders coinciding with a decreasing frequency of infectious diseases in early childhood has led to the speculation that infections may prevent allergic sensitization. Information on the role of parasites in this context is limited. Bro...
