Pyruvate kinase deficiency in sub-Saharan Africa: identification of a highly frequent missense mutation (G829A; Glu277Lys) and association with malaria
PLos ONE; 7 (10), 2012
Background: Pyruvate kinase (PK) deficiency, causing hemolytic anemia, has been associated to malaria protection and its prevalence in sub-Saharan Africa is not known so far. This work shows the results of a study undertaken to determine PK deficiency occurrence in some sub-Saharan African countries, as ...