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Tuberculosis bacillary load, an early marker of disease severity: the utility of tuberculosis Molecular Bacterial Load Assay

Sabiiti, Wilber; Azam, khalide; Farmer, Eoghan Charles William; Kuchaka, Davis; Mtafya, bariki; Bowness, Ruth; Oravcova, katarina.
Thorax; 75 (7), 2020
In this comparative biomarker study, we analysed 1768 serial sputum samples from 178 patients at 4 sites in Southeast Africa. We show that tuberculosis Molecular Bacterial Load Assay (TB-MBLA) reduces time-to-TB-bacillary-load-result from days/weeks by culture to hours and detects early patient treatment...
Antibióticos Antituberculose/uso terapêutico, Carga Bacteriana, Biomarcadores/metabolismo, Mycobacterium tuberculosis/crescimento & desenvolvimento, Mycobacterium tuberculosis/isolamento & purificação, Tuberculose Pulmonar/terapia, d0127200, Prognóstico, Tuberculose Pulmonar/metabolismo, Tuberculose Pulmonar/microbiologia
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Drug-resistant tuberculosis in Central Mozambique: the role of a rapid genotypic susceptibility testing

Namburete, Evangelina Inácio; Tivane, Inês; Lisboa, Miguelhete; Passeri, Margarida; Pocente, Renata; Ferro, Josefo Joao; Harrison, Lee H; Bollela, Valdes Roberto.
BMC infect. dis; 16 (423), 2016
Background: Genotypic molecular testing may be very helpful for tuberculosis (TB) drug-resistance surveillance and for treatment guidance in low resource settings. Methods: Descriptive analysis of M. tuberculosis isolates from Beira Central Hospital, Mozambique, during 2014-2015. Genotype MTBDRplus and ...
Antituberculosos/uso terapêutico, Antituberculosos/farmacologia, Farmacorresistência Bacteriana/efeitos dos fármacos, Etambutol/uso terapêutico, Fluoroquinolonas/uso terapêutico, Testes de Sensibilidade Microbiana, Tuberculose Pulmonar/microbiologia, Mycobacterium tuberculosis/isolamento & purificação, Moçambique
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Mycobacterium tuberculosis Beijing genotype is associated with HIV infection in Mozambique

Viegas, sofia omar; Machado, adelina; Groenheit, Ramona; Ghebremichael, solomon; Pennhag, alexandra; Gudo, eduardo samo; Cuna, zaina; Langa, egídio; Miotto, paolo; Cirillo, Daniela, M.
PLos ONE; 7 (9), 2012
The Beijing genotype is a lineage of Mycobacterium tuberculosis that is distributed worldwide and responsible for large epidemics, associated with multidrug-resistance. However, its distribution in Africa is less understood due to the lack of data. Our aim was to investigate the prevalence and possible t...
Mycobacterium tuberculosis, Infecções Oportunistas Relacionadas com a AIDS/epidemiologia, Infecções Oportunistas Relacionadas com a AIDS/microbiologia, Coinfecção/epidemiologia, Moçambique, Coinfecção/microbiologia, Mycobacterium tuberculosis/genética, Polimorfismo de Fragmento de Restrição, Tuberculose Resistente a Múltiplos Medicamentos/genética, Tuberculose Pulmonar/microbiologia
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Molecular diversity of Mycobacterium tuberculosis isolates from patients with pulmonary tuberculosis in Mozambique

Viegas, sofia omar; Machado, adelina; Groenheit, Ramona; Ghebremichael, solomon; Pennhag, alexandra; Gudo, paula, s; Cuna, zaina; Langa, egídio; Miotto, paolo; Cirillo, Daniela, M.
BMC microbiol; 10 (195), 2010
Background: Mozambique is one of the countries with the highest burden of tuberculosis (TB) in Sub-Saharan Africa, and information on the predominant genotypes of Mycobacterium tuberculosis circulating in the country are important to better understand the epidemic. This study determined the predominant s...
Variação Genética/genética, Dados de Sequência Molecular, Moçambique, Mycobacterium tuberculosis/classificação, Mycobacterium tuberculosis/genética, Mycobacterium tuberculosis/isolamento & purificação, Tuberculose Pulmonar/epidemiologia, Tuberculose Pulmonar/microbiologia
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