Gray, Glenda E;
Mngadi, Kathryn;
Lavreys, Ludo;
Nijs, Steven;
Gilbert, Peter B;
Hural, John;
Hyrien, Ollivier;
Juraska, Michal;
Luedtke, Alex;
Mann, Philipp;
McElrath, M Juliana;
Odhiambo, Jackline A;
Stieh, Daniel J;
Duijn, Janine van;
Takalani, Azwidihwi N;
Willems, Wouter;
Tapley, Asa;
Tomaras, Georgia D;
Hoof, Johan Van;
Schuitemaker, Hanneke;
Swann, Edith;
Barouch, Dan H;
Kublin, James G;
Corey, Lawrence;
Pau, Maria G;
Buchbinder, Susan;
Tomaka, Frank.
Background: HIV type 1 (HIV-1) remains a global health concern, with the greatest burden in sub-Saharan Africa. Despite 40 years of research, no vaccine candidate has shown durable and protective efficacy against HIV-1 acquisition. Although pre-exposure prophylaxis in groups with high vulnerability can b...
Background: Internationally-accredited laboratories are recognised for their superior test reliability, operational performance, quality management and competence. In a bid to meet international quality standards, the Mozambique National Institute of Health enrolled the National Tuberculosis Reference La...
Capitine, Igor P U;
Macicame, Ivalda B;
Uanela, Artur M;
Bhatt, Nilesh B;
Yates, Adam;
Milazzo, Mark;
Nwoga, Chiaka;
Crowell, Trevor A;
Michael, Nelson L;
Robb, Merlin L;
Jani, Ilesh V;
Kroidl, Arne;
Polyak, Christina S;
Schacht, Caroline De.
Introduction: Vaccine efficacy testing requires engagement of willing volunteers with high disease incidence. We evaluated factors associated with willingness to participate in potential future HIV vaccine trials in Maputo, Mozambique.
Methods: Adults aged 18-35 years without HIV and who reported at leas...
Vacinas contra a AIDS/uso terapêutico,
Ensaios Clínicos como Assunto/psicologia,
Infecções por HIV/prevenção & controle,
Conhecimentos, Atitudes e Prática em Saúde,
Motivação,
Moçambique,
Participação do Paciente/psicologia,
Transtornos Fóbicos,
Comportamento Sexual,
Parceiros Sexuais
Capitine, Igor P U;
Macicame, Ivalda B;
Uanela, Artur M;
Bhatt, Nilesh B;
Yates, Adam;
Milazzo, Mark;
Nwoga, Chiaka;
Crowell 3, Trevor A;
Michael, Nelson L;
Robb, Merlin L;
Jani, Ilesh V;
Kroidl, Arne;
Polyak, Christina S;
Schacht, Caroline De.
Introduction: Vaccine efficacy testing requires engagement of willing volunteers with high disease incidence. We evaluated factors associated with willingness to participate in potential future HIV vaccine trials in Maputo, Mozambique.
Methods: Adults aged 18-35 years without HIV and who reported at leas...
Vacinas contra a AIDS/uso terapêutico,
Infecções por HIV/prevenção & controle,
Motivação,
Moçambique,
Ensaios Clínicos como Assunto/psicologia,
Participação do Paciente,
Conhecimentos, Atitudes e Prática em Saúde,
Participação do Paciente/psicologia,
Transtornos Fóbicos,
Comportamento Sexual,
Parceiros Sexuais
Chissumba, Raquel Matavele;
Luciano, Abílio;
Namalango, Eduardo;
Bauer, Asli;
Bhatt, Nilesh;
Wharen, Britta;
Nilsson, Charlotta;
Geldmacher, Christof;
Scarlatti, Gabriella;
Jani, Ilesh;
Kastens, Luc.
Little is known about regulatory CD4 T cells (Tregs) in the context of HIV vaccines. Tregs can be differentiated into resting (FoxP3+CD45RA+ - rTregs), activated (FoxP3HighCD45RA- - aTregs) and memory (FoxP3LowCD45RA- - mTregs). Tregs, as CD4 T cells, are also frequent targets for HIV infection. We studi...
Vacinas contra a AIDS/imunologia,
Anticorpos Neutralizantes/imunologia,
Contagem de Linfócito CD4,
Citocinas/biossíntese,
Anticorpos Anti-HIV/imunologia,
Infecções por HIV/prevenção & controle,
Infecções por HIV/virologia,
HIV-1/imunologia,
HIV-1/genética,
Moçambique,
Linfócitos T CD8-Positivos/imunologia,
Linfócitos T Reguladores/metabolismo,
Vacinas de DNA/imunologia,
Vacinas de DNA/genética
Viegas, Edna O;
Arne, Kroidl;
Munseri, Patricia J;
Missanga, Marco;
Nilsson, Charlotta;
Tembe, Nelson;
Bauer, Asli;
Joachin, Agricola;
Joseph, Sarah;
Mann, Philipp;
Geldmacher, Christof;
Fleck, Sue;
Stöhr, Wolfgang;
Scarlatti, Gabriella;
Aboud, Said;
Bakari, Muhammad;
Maboko, Leonard;
Hoelscher, Michael;
Wahren, Britta;
Robb, Merlin L;
Weber, Jonathan;
McCormack, Sheena;
Biberfeld, Gunnel;
Jani, Ilesh V;
Sandström, Eric;
Lyamuya, Eligius.
Background: We evaluated the safety and immunogenicity of (i) an intradermal HIV-DNA regimen given with/without intradermal electroporation (EP) as prime and (ii) the impact of boosting with modified vaccinia virus Ankara (HIV-MVA) administered with or without subtype C CN54rgp140 envelope protein adjuva...
Adulto Jovem,
Vacinas Virais,
Alergia e Imunologia,
Genética,
Vacinas de DNA,
Vacinação,
Tanzânia/epidemiologia,
Moçambique/epidemiologia,
Humanos,
Voluntários Saudáveis,
Eletroporação,
Anticorpos Neutralizantes,
Adulto,
Administração Cutânea,
Vacinas contra a AIDS
Viegas, Edna Omar;
Tembe, Nelson;
Nilsson, Charlotta;
Meggi, Bindiya;
Maueia, Cremildo;
Augusto, Orvalho;
Stout, Richard;
Scarlatti, Gabriella;
Ferrari, Guido;
Earl, Patricia L;
Wahren, Britta;
Andersson, Soren.
According to UNAIDS, there were a total of 36.7 million people living with HIV and 2.1 million new infections in 2015. Eastern and Southern Africa continues to be most severely affected, accounting for 51.7% of the total global infections. Antiretroviral therapy has contributed to slowing the HIV epidemi...
Voronin, yegor;
Jani, ilesh;
Graham, barney, s;
Cunningham, coleen, k;
Mofenson, lynne, m;
Musoke, philippa, m;
Permar, sallie, r;
Scarlatti, gabriella.
Globally, 150,000 new paediatric human immunodeficiency virus type 1 (HIV-1) infections occurred in 2015. There remain complex challenges to the global elimination of paediatric HIV-1 infection. Thus, for the global community to achieve elimination of new paediatric HIV-1 infections, innovative approache...
HIV-1,
HIV-1/imunologia,
Vacinas contra a AIDS/administração & dosagem,
Anticorpos Anti-HIV,
Vacinas contra a AIDS/imunologia,
Infecções por HIV,
Anticorpos Neutralizantes/imunologia,
Anticorpos Anti-HIV/imunologia,
Infecções por HIV/imunologia,
Infecções por HIV/prevenção & controle,
Infecções/virologia,
Transmissão Vertical de Doenças Infecciosas/prevenção & controle
