Regulatory T cell abundance and activation status before and after priming with HIVIS-DNA and boosting with MVA-HIV/rgp140/GLA-AF may impact the magnitude of the vaccine-induced immune responses
Immunobiol., Suppl; 223 (12), 2018
Little is known about regulatory CD4 T cells (Tregs) in the context of HIV vaccines. Tregs can be differentiated into resting (FoxP3+CD45RA+ - rTregs), activated (FoxP3HighCD45RA- - aTregs) and memory (FoxP3LowCD45RA- - mTregs). Tregs, as CD4 T cells, are also frequent targets for HIV infection. We studi...
Vacinas contra a AIDS/imunologia, Anticorpos Neutralizantes/imunologia, Contagem de Linfócito CD4, Citocinas/biossíntese, Anticorpos Anti-HIV/imunologia, Infecções por HIV/prevenção & controle, Infecções por HIV/virologia, HIV-1/imunologia, HIV-1/genética, Moçambique, Linfócitos T CD8-Positivos/imunologia, Linfócitos T Reguladores/metabolismo, Vacinas de DNA/imunologia, Vacinas de DNA/genética