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Regulatory T cell abundance and activation status before and after priming with HIVIS-DNA and boosting with MVA-HIV/rgp140/GLA-AF may impact the magnitude of the vaccine-induced immune responses

Chissumba, Raquel Matavele; Luciano, Abílio; Namalango, Eduardo; Bauer, Asli; Bhatt, Nilesh; Wharen, Britta; Nilsson, Charlotta; Geldmacher, Christof; Scarlatti, Gabriella; Jani, Ilesh; Kastens, Luc.
Immunobiol., Suppl; 223 (12), 2018
Little is known about regulatory CD4 T cells (Tregs) in the context of HIV vaccines. Tregs can be differentiated into resting (FoxP3+CD45RA+ - rTregs), activated (FoxP3HighCD45RA- - aTregs) and memory (FoxP3LowCD45RA- - mTregs). Tregs, as CD4 T cells, are also frequent targets for HIV infection. We studi...
Vacinas contra a AIDS/imunologia, Anticorpos Neutralizantes/imunologia, Contagem de Linfócito CD4, Citocinas/biossíntese, Anticorpos Anti-HIV/imunologia, Infecções por HIV/prevenção & controle, Infecções por HIV/virologia, HIV-1/imunologia, HIV-1/genética, Moçambique, Linfócitos T CD8-Positivos/imunologia, Linfócitos T Reguladores/metabolismo, Vacinas de DNA/imunologia, Vacinas de DNA/genética
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Optimizing the immunogenicity of HIV prime-boost DNA-MVA-rgp140/GLA vaccines in a phase II randomized factorial trial design

Viegas, Edna O; Arne, Kroidl; Munseri, Patricia J; Missanga, Marco; Nilsson, Charlotta; Tembe, Nelson; Bauer, Asli; Joachin, Agricola; Joseph, Sarah; Mann, Philipp; Geldmacher, Christof; Fleck, Sue; Stöhr, Wolfgang; Scarlatti, Gabriella; Aboud, Said; Bakari, Muhammad; Maboko, Leonard; Hoelscher, Michael; Wahren, Britta; Robb, Merlin L; Weber, Jonathan; McCormack, Sheena; Biberfeld, Gunnel; Jani, Ilesh V; Sandström, Eric; Lyamuya, Eligius.
PLos ONE; 13 (11), 2018
Background: We evaluated the safety and immunogenicity of (i) an intradermal HIV-DNA regimen given with/without intradermal electroporation (EP) as prime and (ii) the impact of boosting with modified vaccinia virus Ankara (HIV-MVA) administered with or without subtype C CN54rgp140 envelope protein adjuva...
Adulto Jovem, Vacinas Virais, Alergia e Imunologia, Genética, Vacinas de DNA, Vacinação, Tanzânia/epidemiologia, Moçambique/epidemiologia, Humanos, Voluntários Saudáveis, Eletroporação, Anticorpos Neutralizantes, Adulto, Administração Cutânea, Vacinas contra a AIDS
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Intradermal HIV-1 DNA immunization using needle-free zetajet injection followed by HIV-modified Vaccinia virus ankara vaccination is safe and immunogenic in Mozambican young adults: A Phase i randomized controlled trial

Viegas, Edna Omar; Tembe, Nelson; Nilsson, Charlotta; Meggi, Bindiya; Maueia, Cremildo; Augusto, Orvalho; Stout, Richard; Scarlatti, Gabriella; Ferrari, Guido; Earl, Patricia L; Wahren, Britta; Andersson, Soren.
AIDS res. hum. retrovir; 34 (2), 2018
According to UNAIDS, there were a total of 36.7 million people living with HIV and 2.1 million new infections in 2015. Eastern and Southern Africa continues to be most severely affected, accounting for 51.7% of the total global infections. Antiretroviral therapy has contributed to slowing the HIV epidemi...
Anticorpos Anti-HIV, ELISPOT, Injeções Intramusculares, Produtos do Gene env do Vírus da Imunodeficiência Humana/imunologia, Moçambique, Leucócitos Mononucleares/imunologia, Vacinas de DNA/imunologia, Vacinas contra a AIDS/imunologia, Vacinas contra a AIDS/administração & dosagem, Imunização
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