RDSM – Rede de Documentação sobre Saúde em Moçambique

Regulatory T cell abundance and activation status before and after priming with HIVIS-DNA and boosting with MVA-HIV/rgp140/GLA-AF may impact the magnitude of the vaccine-induced immune responses

Chissumba, Raquel Matavele; Luciano, Abílio; Namalango, Eduardo; Bauer, Asli; Bhatt, Nilesh; Wharen, Britta; Nilsson, Charlotta; Geldmacher, Christof; Scarlatti, Gabriella; Jani, Ilesh; Kastens, Luc.

Immunobiol., Suppl; 223 (12), 2018

Little is known about regulatory CD4 T cells (Tregs) in the context of HIV vaccines. Tregs can be differentiated into resting (FoxP3+CD45RA+ - rTregs), activated (FoxP3HighCD45RA- - aTregs) and memory (FoxP3LowCD45RA- - mTregs). Tregs, as CD4 T cells, are also frequent targets for HIV infection. We studi...

Vacinas contra a AIDS/imunologia, Anticorpos Neutralizantes/imunologia, Contagem de Linfócito CD4, Citocinas/biossíntese, Anticorpos Anti-HIV/imunologia, Infecções por HIV/prevenção & controle, Infecções por HIV/virologia, HIV-1/imunologia, HIV-1/genética, Moçambique, Linfócitos T CD8-Positivos/imunologia, Linfócitos T Reguladores/metabolismo, Vacinas de DNA/imunologia, Vacinas de DNA/genética

Texto completo

Intradermal HIV-1 DNA immunization using needle-free zetajet injection followed by HIV-modified Vaccinia virus ankara vaccination is safe and immunogenic in Mozambican young adults: A Phase i randomized controlled trial

According to UNAIDS, there were a total of 36.7 million people living with HIV and 2.1 million new infections in 2015. Eastern and Southern Africa continues to be most severely affected, accounting for 51.7% of the total global infections. Antiretroviral therapy has contributed to slowing the HIV epidemi...