Whole genome analyses of DS-1-like Rotavirus A strains detected in children with acute diarrhoea in southern Mozambique suggest several reassortment events

Infect. gent. evol; 69 (), 2019
Ano de publicação: 2019

Rotavirus (RV) is an important enteric pathogen in the young of many mammalian and avian species. The virus belongs to the Reoviridae family and contains an 11-segmented double-stranded RNA (dsRNA) genome. The dsRNA segments encode six structural (VP1–4, 6 and 7) and six non-structural (NSP1–5/6) proteins. The viral particle consists of outer capsid (VP4 and VP7), inner capsid (VP6) and core (VP2 encasing VP1 and VP3) proteins which encloses the nucleic acid material (Estes and Greenberg, 2013). Based on genotyping targeting genome segment 6 which encodes VP6, RVs are classified into eight groups (RVA – RVH) with an additional two proposed groups, I and J (Bányai et al., 2017; Matthijnssens et al., 2012; Mihalov-Kovács et al., 2015)....

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