This thesis presents a set of recommendationsarising fromassessment of the Management Information Systems for Drug Supplies in PublicHealth Facilities of Ethiopia through a case studyfromAddis Ababa. Healthcare is one of the crucial components of basic social services that have a direct linkage to the growthand development of a countryas well as to the welfare of a society.Given the overwhelming povertyand the resultant scarcityof resources for the health sector in most developing countries, proper allocation and utilization of resources is crucial for realizing effective health service delivery. Drugs are among the most important resources in the health system. Their availability, accessibility, and rational use, however is questionable in most settings in the developing world due to variousreasons, where amongst other reasons, the lack of information based management decision making is the key one. Thus addressing such managerial problems surrounding information systems requires assessing the existing situation and suggesting recommendations that can strengthen the system. Hence, this studyassessed the Drug Logistics Management Information Systems (DLMIS) in public health facilities of Ethiopia in terms ofdata management and information use for action. Moreover, the studyexplored factors associated withthe functionalityof the information system. This assessment isbased on a case studyfollowed byaction research interventions aimed at strengthening the DLMIS. Empirically, the research applied qualitative research methods such as interviews, document analysis and observation within the framework of interpretative approach informed by structuration theory to analyze and understand the existing contextual situation. The analysis identified that currentlythe DLMIS was grosslyineffective due to various reasons such as the absence of standardized data collection tools, absence of standardoperational procedures or clearly defined job descriptions, lack of information system resources support,lack of monitoring and evaluation tools, lack of information use culture and feedback, sub standardized manpower allocation, inconvenient working atmosphere and lack of relevant training, and poor inter departmental communication Understanding the presence of these issues helpedto develop somerecommendations and implement some of themthrough an action researchapproach, which led to both theoretical and practical contributions. Theoretically, the studycontributed through developinga conceptual model that help explore the relation between the following three sub systems identified tobe fundamental in shaping the drugs system: DLMIS, Drug Supplies Managementand Health Service Delivery. Furthermore, the model describes analytically how the current DLMIS and Drug Supplies Management are mutuallyrelated, and how this shapes Health Service Delivery. Practically, the studycontributesas a baseline for further studies and interventions towards strengthening a given DLMIS through developingstandard formats, standard operational procedure, introducing simple computerized data collection tools and providingsome additional recommendations. Moreover, the studyemphasized theneed for well-organized and institutionalized pharmaceutical management along all health administration levels to guide and follow the performance of the system