This thesis presents a set of recommendations arising from assessment of the Management Information Systems for Drug Supplies in Public Health Facilities of Ethiopia through a case study from Addis Ababa. Healthcare is one of the crucial components of basic social services that have a direct linkage to the growth and development of a country as well as to the welfare of a society. Given the overwhelming poverty and the resultant scarcity of resources for the health sector in most developing countries, proper allocation and utilization of resources is crucial for realizing effective health service delivery. Drugs are among the most important resources in the health system. Their availability, accessibility, and rational use, however is questionable in most settings in the developing world due to various reasons, where amongst other reasons, the lack of information based management decision making is the key one. Thus addressing such managerial problems surrounding information systems requires assessing the existing situation and suggesting recommendations that can strengthen the system. Hence, this study assessed the Drug Logistics Management Information Systems (DLMIS) in public health facilities of Ethiopia in terms of data management and information use for action. Moreover, the study explored factors associated with the functionality of the information system. This assessment is based on a case study followed by action research interventions aimed at strengthening the DLMIS. Empirically, the research applied qualitative research methods such as interviews, document analysis and observation within the framework of interpretative approach informed by structuration theory to analyze and understand the existing contextual situation. The analysis identified that currently the DLMIS was grossly ineffective due to various reasons such as the absence of standardized data collection tools, absence of standard operational procedures or clearly defined job descriptions, lack of information system resources support, lack of monitoring and evaluation tools, lack of information use culture and feedback, sub standardized manpower allocation, inconvenient working atmosphere and lack of relevant training, and poor inter departmental communication Understanding the presence of these issues helped to develop some recommendations and implement some of them through an action research approach, which led to both theoretical and practical contributions. Theoretically, the study contributed through developing a conceptual model that help explore the relation between the following three sub systems identified to be fundamental in shaping the drugs system: DLMIS, Drug Supplies Management and Health Service Delivery. Furthermore, the model describes analytically how the current DLMIS and Drug Supplies Management are mutually related, and how this shapes Health Service Delivery. Practically, the study contributes as a baseline for further studies and interventions towards strengthening a given DLMIS through developing standard formats, standard operational procedure, introducing simple computerized data collection tools and providing some additional recommendations. Moreover, the study emphasized the need for well-organized and institutionalized pharmaceutical management along all health administration levels to guide and follow the performance of the system.