Total: 6329

Boletim epidemiológico: situação epidemiológica de HIV e aids em adultos no estado de Goiás, 2020 a 2024
Epidemiological bulletin: epidemiological situation of HIV and AIDS in adults in the state of Goiás, 2020 to 2024

Boletim epidemiológico que apresenta informações sobre os casos de HIV no estado de Goiás e tem como objetivo descrever o perfil epidemiológico, tendências da infecção na população adulta entre os anos 2020 a 2024 e fornecer subsídios para a tomada de decisão, medidas de vigilância, prevenç...

Development and content validity of a questionnaire on peripheral intravenous catheter maintenance and knowledge of nursing professionals regarding best practices

J. infus. nurs; 48 (1), 2025
The aims of this study were to develop a questionnaire on peripheral intravenous catheter (PIVC) maintenance, evaluate its content validity, and assess factors influencing the level of knowledge of nursing professionals regarding best practices.The study was conducted in 3 stages: (1) development of a qu...

Comparison of metformin with inositol versus metformin alone in women with polycystic ovary syndrome: a systematic review and meta-analysis of randomized controlled trials

Endocrine; 87 (2), 2025
PURPOSE: Metformin was the first medication targeting insulin resistance in PCOS, and it has been extensively studied as a metabolic treatment option. In recent years, inositols have emerged as potential treatment options for PCOS, but confidence in the available evidence supporting their use is limited....

Association of baseline neutrophil-to-lymphocyte ratio and prognosis in melanoma patients treated with PD-1/PD-L1 blockade: a systematic review and meta-analysis

Melanoma res; 35 (1), 2025
Immunotherapy treatments that target programmed cell death receptor-1 (PD-1) or its ligand (PD-L1) have revolutionized the treatment of metastatic melanoma and currently represent the standard first-line treatment for this type of cancer. However, it is still not entirely clear which biomarkers are cost-...

Stroke risk in cancer survivors: a systematic review and meta-analysis

Stroke; 56 (Suppl.1), 2025
BACKGROUND: It is suggested that survivors of different types of cancer may have an increased risk of stroke. Our study aims to evaluate cancer patients and non-cancer controls by analyzing stroke events in each group. Previous studies concluded that certain types of cancer increased stroke risk, however...

Apixaban for preventing recurrence of ischemic stroke in patients with atrial cardiopathy: a systematic review and meta-analysis

Stroke; 56 (Suppl.1), 2025
INTRODUCTION: Preventing ischemic strokes in patients with atrial cardiopathy is particularly challenging due to the elevated risks associated with the condition. While numerous studies have established the efficacy of anticoagulants in preventing stroke, their benefits for patients with atrial cardiopat...

Effects of Tirofiban on early neurological deterioration in patients with acute ischemic stroke: a systematic review and meta- analysis

Stroke; 56 (Suppl.1), 2025
INTRODUCTION: Early neurological deterioration (END) is an adverse outcome of acute ischemic stroke that affects up to one-third of patients and is linked to poorer functional outcomes. Tirofiban, a nonpeptide glycoprotein IIb/IIIa receptor blocker, is widely used in the treatment of atherosclerotic hear...

PD-1/PD-l1 inhibitors increase pathological complete response in locally advanced gastric cancer: a meta-analysis and trial sequential analysis

BACKGROUND AND OBJECTIVE: Gastric cancer (GC) remains a leading cause of morbidity and mortality worldwide. The current standard of care involves neoadjuvant chemotherapy (NACT) followed by radical gastrectomy. This study aims to evaluate the efficacy of neoadjuvant therapy with PD-1/PD-L1 inhibitors in ...

Dermatófitos em cães e gatos e seu contexto na saúde pública: revisão de literatura

A dermatofitose é uma infecção micótica superficial dos tecidos queratinizados como pelos, unhas e o estrato córneo da epiderme. Nos cães e gatos, esta enfermidade é comumente causada por fungos dermatófitos dos gêneros Microsporum, Nannizzia e Trichophyton que p...

Cardiovascular benefits of statin plus ezetimibe combination therapy versus statin monotherapy in acute coronary syndrome: a meta-analysis of randomized controlled trials

Coron. artery dis; 36 (1), 2025
BACKGROUND: The efficacy of adding ezetimibe to statin therapy for event reduction in patients with acute coronary syndromes (ACS) remains a topic of ongoing debate. METHODS: We performed a systematic review and meta-analysis of randomized controlled trials (RCTs) comparing ezetimibe plus statin versus s...