Immunotherapy treatments that target programmed cell death receptor-1 (PD-1) or its ligand (PD-L1) have revolutionized the treatment of metastatic melanoma and currently represent the standard first-line treatment for this type of cancer. However, it is still not entirely clear which biomarkers are cost-...
de Oliveira Almeida, Gustavo;
Balieiro, Caroline;
Bertoli, Edmundo Damiani;
Moreira, Maria Eduarda Liporaci;
Silva, Ana Laura Soares;
Minucci, Bárbara Silvestre;
Zapparoli, Isabella;
Maluf, Marcela Silva;
Carvalho, Henrique Champs Porfírio;
Dos Santos Borges, Rafael;
Pasqualotto, Eric;
Nienkötter, Thiago;
Alves, Vinícius;
Guida, Camila Mota.
BACKGROUND: The efficacy of adding ezetimibe to statin therapy for event reduction in patients with acute coronary syndromes (ACS) remains a topic of ongoing debate.
METHODS: We performed a systematic review and meta-analysis of randomized controlled trials (RCTs) comparing ezetimibe plus statin versus s...
INTRODUCTION: Renal denervation has been associated with substantial and sustained blood pressure reduction and is considered to serve as an alternative treatment for patients with resistant hypertension. However, the first published SHAM-controlled trial assessing RDN safety and efficacy showed no diffe...
Valente, B. P;
Coelho, B. P. A;
Pinto, I. M. F;
Senra, T;
Junior, J. R. T. P;
Delamain, J. H. H. D;
Cervone, A. C. C;
Junior, J. R. C;
Souto, M. J. S;
Naranjo, G. C. S;
Sanches, F. B;
Santos, B. V;
Queiroz, G. S;
Valente, O. P;
Farsky, P. S.
INTRODUCTION: In patients with ST-elevation myocardial infarction (STEMI), percutaneous coronary intervention (PCI) should be conducted within 12 hours of symptom onset. The potential benefits attributable to late reperfusion in STEMI fall under the "open artery hypothesis" where the stunned peri-infarct...
Fernandes, F;
Luzuriaga, G. C. J;
Correia, E. B;
Carvalho, A. V. S;
Macedo, A. V. S;
Coelho Filho, O. R;
Scheinberg, P;
Antunes, M. O;
Schwartzmann, P. V;
Mangini, S;
Marques, W;
Simoes, M. V;
Ubner, C. C.
INTRODUCTION: Transthyretin amyloidosis (ATTR) is a multisystem disease caused by the deposition of fibrillar protein in organs and tissues. ATTR genotypes and phenotypes are highly heterogeneous. PURPOSE: We designed the Transthyretin Cardiac Amyloidosis Registry in the state of São Paulo (REACT-SP), a...
BACKGROUND: Bevacizumab is a monoclonal antibody medication used as standard treatment for different types of cancers, one of them is glioblastoma, which is the most common primary brain tumor. PURPOSE: We aimed to assess bevacizumab and its effects on inducing hypertension in patients with glioblastoma....
BACKGROUND: The ideal blood pressure target level for preventing cognitive decline or dementia in patients with systemic arterial hypertension (SAH) remains unclear. PURPOSE: This study aims to investigate whether intensive blood pressure reduction compared to standard treatment is associated with a redu...
BACKGROUND/INTRODUCTION: Renal denervation (RDN) is an innovative procedure designed to regulate the renal sympathetic nervous system for the control of arterial hypertension (HTN). RDN emerges as an alternative for patients with resistant arterial hypertension. Despite this, the clinical efficacy of RDN...
Kelly, F. Alves;
Lobo, A. Oliveira Macena;
Moraes, F.C. Aquino de;
Morbach, V;
Sano, V. Kendi Tsuchiya;
Almeida, A. Menegaz de;
Consolim-Colombo, F. Marciano;
Laurinavicius, A;
Sousa, M. Goncalves de;
Souza, J. Batista.
BACKGROUND: Atherosclerotic cardiovascular disease (ASCVD), affects approximately 18.6 million individuals worldwide, poses an important healthcare challenge. Despite the established efficacy of both high-intensity statin monotherapy (HIS) and moderate-intensity statin plus ezetimibe (MIS+EZT) in ASCVD m...
INTRODUÇÃO: A ablação por cateter de Taquicardia Ventricular (TV) em pacientes com Cardiomiopatia Chagásica Dilatada (CCD) pode ser desafiadora devido à complexidade do substrato. Afinalidade do procedimento é a redução do número de TVs e de terapias dos cardiodesfibriladores implantáveis, res...
