Mazetto, Roberto;
Bulhoes, Elisio;
Antunes, Vanio do Livramento Junior;
Defante, Maria Luiza Rodrigues;
Garcez, Luanna;
Barbosa, Lucas Federal;
Queiroz, Ivo;
Mendes, Beatriz X;
Bastos, Eduarda;
Silva, Catarina;
Coelho, Anderson;
Guerreiro, Isabel;
Couceiro, Katia;
Bueno, Bruno;
Guida, Camila;
Macedo, Harthur Moreira;
Romeiro, Pedro.
BACKGROUND: Some studies suggest a potential benefit of hybrid ablation for patients with persistent and long-standing persistent atrial fibrillation (AF), but its efficacy and safety remain debated. OBJECTIVE: We conducted a systematic review and meta-analysis to compare the efficacy and safety of hybri...
BACKGROUND: Embolic stroke of undetermined source (ESUS) is a nonlacunar ischemic stroke with no clear cause, having a 4%-5% annual recurrence rate. The potential benefits of direct oral anticoagulants (DOACs) relative to aspirin in patients with ESUS remain unclear. OBJECTIVE: We aimed to perform a syst...
Defante, Maria Luiza Rodrigues;
Mendes, Beatriz X;
Queiroz, Ivo;
Mazetto, Roberto;
Barbosa, Lucas;
Romeiro, Pedro;
Antunes, Vanio;
Bulhoes, Elisio;
Silva, Catarina;
Guida, Camila.
BACKGROUND: Sodium-glucose cotransporter 2 inhibitors (SGLT2i) have demonstrated cardiovascular benefits in various settings. However, their impact after myocardial infarction (MI) in patients without prior heart failure remains unclear. Therefore, we conducted a meta-analysis comparing SGLT2i to placebo...
Ferreira, Andre Carvalho;
Antunes, Vanio do Livramento Junior;
Guida, Camila;
Souza, Luciana Vergara Ferraz de;
Rodrigues, Maria Luiza;
Bulhoes, Elisio;
Begic, Edin;
Aziri, Buena;
Mazetto, Roberto;
Monteiro, Sarah;
Garcez, Luanna;
Benitez, Maria.
INTRODUCTION: AI-based EKG has shown good accuracy for diagnosing heart failure. However, due to the heterogeneity of studies regarding cutoff points, its precision for specifically detecting heart failure with reduced ejection fraction (LVEF <40%) is not yet well established. Research question: What it ...
Queiroz, Ivo;
Barbosa, Lucas;
Defante, Maria Luiza Rodrigues;
Mendes, Beatriz X;
Junior Antunes, Vanio do Livramento;
Romeiro, Pedro;
Mazetto, Roberto;
Silva, Catarina;
Bulhoes, Elisio;
Guida, Camila.
BACKGROUND: Acute paroxysmal supraventricular tachycardia (PSVT) is a common arrhythmia. Etripamil, a novel calcium channel blocker via nasal spray, has shown promise for PSVT management. This meta-analysis and trial sequential analysis (TSA) evaluates the efficacy and safety of nasal Etripamil for treat...
Nishimura, Thiago;
Damiani, Lucas;
Shinzato, Mariane;
Santos, Natasha;
Farias, Eduardo da Silva;
Shiguematsu, Victor;
Batista, Fernanda;
Feres, Lara;
Damiani, Bruna;
Delamain, Tacianne;
Nishida, Gustavo;
Samaan, Farid;
Feres, Fausto;
Franchini, Kleber.
INTRODUCTION: Chronic kidney disease (CKD) is a critical comorbidity in heart failure with preserved ejection fraction (HFpEF), often linked to congestion due to elevated filling pressures. However, the role of subtle systolic dysfunction in CKD remains to be elucidated. This study aimed to investigate t...
Queiroz, Ivo;
Defante, Maria Luiza Rodrigues;
Barbosa, Lucas;
Mendes, Beatriz X;
Antunes, Vanio do Livramento Junior;
Mazetto, Roberto;
Bulhoes, Elisio;
Silva, Catarina;
Romeiro, Pedro;
Guida, Camila.
BACKGROUND: With the rising use of artificial sweeteners as sugar substitutes, concerns regarding their impact on cardiovascular health have emerged. Despite approval by national food regulatory agencies, evidence of their association with clinically significant cardiovascular events remains inconclusive...
Avelino, Thayná M;
Harb, Samarah V;
Adamoski, Douglas;
Oliveira, Larissa C M;
Horinouchi, Cintia D S;
Azevedo, Rafael J de;
Azoubel, Rafael A;
Thomaz, Vanessa K;
Batista, Fernanda A H;
d'Ávila, Marcos Akira;
Granja, Pedro L;
Figueira, Ana Carolina M.
3D skin models have been explored as an alternative method to the use of animals in research and development. Usually, human skin equivalents comprise only epidermis or epidermis/dermis layers. Herein, we leverage 3D bioprinting technology to fabricate a full-thickness human skin equivalent with hypoderm...
BACKGROUND: Breast cancer (BC) is a significant global health issue, accounting for 1 in 8 cancer diagnoses worldwide. HLA class I molecules are typically expressed on the cell surface, but cancer cells can develop mechanisms to evade recognition by CTLs, including the downregulation of HLA class I expre...
FUNDAMENTO: Devido à grande quantidade de receptores para transplante de coração (TxC) e a falta de doadores, a fila de espera mesmo em prioridade por dependência inotrópica pode ser longa. Os beta-bloqueadores (BB) são fármacos de primeira linha no tratamento da insuficiência cardíaca de fraç...
