Bulhoes, Elisio;
Farias, Carlos;
Florindo, Mayara;
Silva, Gustavo Fernandes da;
Holmvard, Oscar;
Silva, Ana Laura Soares;
Ferreira, Andre Carvalho;
Sales, Gabriel;
Schneider, Andre;
Roesch, Heveline Rayane Moura;
Guida, M Camila.
INTRODUCTION: Cancer therapy-induced cardiac dysfunction is a significant adverse effect of chemotherapeutic agents, particularly anthracyclines (ANT). High-potency statin therapy, such as atorvastatin, appears to exert a protective effect against this condition. OBJECTIVE: We aimed to perform a meta-ana...
In daily clinical practice, cardiologists are confronted with patients with HIV/AIDS and this population needs special attention due to their higher cardiovascular risk. Studies show an increase in cardiovascular disease (CVD) among people with HIV/AIDS and one of the main causes of death in this group. ...
Kelly, F. Alves;
Lobo, A. Oliveira Macena;
Moraes, F.C. Aquino de;
Morbach, V;
Sano, V. Kendi Tsuchiya;
Almeida, A. Menegaz de;
Consolim-Colombo, F. Marciano;
Laurinavicius, A;
Sousa, M. Goncalves de;
Souza, J. Batista.
BACKGROUND: Atherosclerotic cardiovascular disease (ASCVD), affects approximately 18.6 million individuals worldwide, poses an important healthcare challenge. Despite the established efficacy of both high-intensity statin monotherapy (HIS) and moderate-intensity statin plus ezetimibe (MIS+EZT) in ASCVD m...
Biaso, Sarah Tucci de;
Faludi, André Arpad;
Araujo, Daniel Branco de;
Zatz, Henri Paulo;
Santos, Natasha Soares Simões dos;
Carmo, Luna Varela do;
Araujo Filho, Edmur Carlos de;
Pires, Mário Salomão Cury;
Faria, Magno Martins Pinto de;
Yoshioka, Caroline Yukari.
INTRODUÇÃO: A hipercolesterolemia, em particular o aumento dos níveis de lipoproteína de baixa densidade (LDL), é um fator de risco bem estabelecido para o desenvolvimento e progressão de doenças cardiovasculares. A terapia com estatinas tem sido amplamente utilizada para reduzir os níveis de LDL...
BACKGROUND: Contemporary understanding characterizes cardiotoxicity as a reduction in left ventricular ejection fraction (LVEF) by at least 10%, resulting in a final value below 53% in successive assessments. Nevertheless, breast cancer therapy can impact the cardiovascular system through various avenues...
BACKGROUND Breast cancer (BC) incidence is estimated to achieve over 3 million new cases and 1 million deaths by 2040. Beyond its physical toll, breast cancer detrimentally affects quality of life, imposing emotional, social, and financial burdens on patients and their families. Statins, commonly prescri...
BACKGROUND
Atherosclerotic cardiovascular disease (ASCVD), affects approximately 18.6 million individuals worldwide and poses a significant healthcare related challenge. Despite the established efficacy of both high-intensity statin monotherapy (HIS) and moderate-intensity statin plus ezetimibe (MIS+EZT)...
Dagli-Hernandez, Carolina;
Ferreira, Glaucio Monteiro;
Freitas, Renata Caroline Costa de;
Borges, Jessica Bassani;
Oliveira, Victor Fernandes de;
Gonçalves, Rodrigo Marques;
Faludi, Andre Arpad;
Marçal, Elisangela da Silva Rodrigues;
Bastos, Gisele Medeiros;
Bortolin, Raul Hernandes;
Hirata, Mario Hiroyuki;
Hirata, Rosario Dominguez Crespo.
OBJECTIVES: This study explored the association of deleterious variants in pharmacodynamics (PD) genes with statin response and adverse effects in patients with familial hypercholesterolemia (FH) and analyzed their potential effects on protein structure and stability.
METHODS: Clinical and laboratory dat...
Oliveira, Gustavo;
Balieiro, Caroline;
Silva, Ana Laura Soares;
Minucci, Barbara;
Braga, Marcelo;
Pasqualotto, Eric;
Nienkötter, Thiago;
Bertoli, Edmundo;
Alves, Vinicius;
Chavez, Matheus Pedrotti;
Ferreira, Rafael;
Assunção, Pâmela;
Guida, Camila Mota.
BACKGROUND: The efficacy of adding ezetimibe to statin therapy for event reduction in patients with acute coronary syndromes (ACS) remains a topic of ongoing debate. METHODS: We performed a systematic review and meta-analysis of randomized controlled trials (RCTs) comparing ezetimibe plus statin versus s...
Cerda, Alvaro;
Bortolin, Raul Hernandes;
Yoshinaga, Marcos Yukio;
Freitas, Renata Caroline Costa de;
Dagli-Hernandez, Carolina;
Borges, Jessica Bassani;
Oliveira, Victor Fernandes de;
Gonçalves, Rodrigo Marques;
Faludi, Andre Arpad;
Bastos, Gisele Medeiros;
Hirata, Rosario Dominguez Crespo;
Hirata, Mario Hiroyuki.
Familial hypercholesterolemia (FH) is a disorder of lipid metabolism that causes elevated low-density lipoprotein cholesterol (LDL-c) and increased premature atherosclerosis risk. Statins inhibit endogenous cholesterol biosynthesis, which reduces LDL-c plasma levels and prevent from cardiovascular events...
