Introdução: O carcinoma endometrial (CE) foi classificado pelo sistema de Bokhman em tipos I e II com base em observações clínicas e epidemiológicas. O tipo I corresponde aos tumores de baixo grau e o tipo II aos tumores de alto grau. Adicionalmente, estudos recentes propuseram que a classificaçã...
BACKGROUND Cancer is a life-threatening disease that affects approximately 18 million individuals worldwide. Breast cancer is the most common female neoplasm globally with more than 276,480 new cases of invasive breast cancer expected to be diagnosed in women in the U.S. alone in 2020. Genetic and epigen...
ABSTRACT The concomitant epidermal growth factor receptor (EGFR) mutation and anaplastic lymphoma kinase (ALK) translocations in lung adenocancers are very rare scenarios. Until now, 42 cases described in the literature have all been treated by different drugs. There is no overall consensus regarding the...
Adenocarcinoma/genética,
Neoplasias Pulmonares/genética,
Mutación/genética,
Genes erbB-1/genética,
Exones/genética,
Crizotinib/uso terapéutico,
Inhibidores de Proteínas Quinasas/uso terapéutico,
Docetaxel/uso terapéutico,
Cisplatino/uso terapéutico,
Antineoplásicos/uso terapéutico,
Neoplasias Pulmonares/tratamiento farmacológico,
Adenocarcinoma/tratamiento farmacológico
Abstract Background: Ovarian cancer is the most lethal gynecologic cancer. Although most patients respond adequately to the first-line therapy, up to 85% experience a recurrence of disease, which carries a poor prognosis. Mitotic arrest deficiency 1 is a protein that helps in the assembly of the mitotic...
Castoldi, Diogo Francesco;
Malafaia, Osvaldo;
Santos-Neto, Pedro Helo dos;
Postiglioni, Tatiana Varella;
Vasconcelos, Cecilia;
Bremer, Fabiola Past;
Czeczko, Leticia Elizabeth Augustin;
Gasser, Martin;
Waaga-Gasser, Ana Maria;
Ribas, Carmen Australia Paredes Marcondes.
ABSTRACT Background: Studies with biomarkers in TMA (tissue microarray) have been showing important results regarding its expression in colon cancer. Aim: Correlate the expression profile of the OPN and ABCB5 biomarkers with the epidemiological and clinicopathological characteristics of the patients, t...
ABSTRACT BACKGROUND: Gastric cancer is the fourth most common cause of worldwide cancer. Also in contrast to the huge advances in curing, the chance of living is very low even in surgery cases. Having a genetic predisposition plays an important role in cancer development. The association between Metall...
Adenocarcinoma/genética,
Estudios de Casos y Controles,
Estudios Transversales,
Predisposición Genética a la Enfermedad/genética,
Genotipo,
Metalotioneína/genética,
Persona de Mediana Edad,
Reacción en Cadena de la Polimerasa,
Polimorfismo de Longitud del Fragmento de Restricción,
Polimorfismo de Nucleótido Simple/genética,
Neoplasias Gástricas/genética
Resumen El objetivo de esta revisión es realizar una actualización de los conocimientos actuales en cáncer gástrico hereditario, especialmente enfocado a que pacientes tienen indicación de estudio genético y su manejo clínico. En un 5-10% de los cánceres gástricos existe un patrón familiar. Los...
Silva, Tabata M;
Moretto, Fernanda C F;
Sibio, Maria T De;
Gonçalves, Bianca M;
Oliveira, Miriane;
Olimpio, Regiane M C;
Oliveira, Diego A M;
Costa, Sarah M B;
Deprá, Igor C;
Namba, Vickeline;
Nunes, Maria T;
Nogueira, Célia R.
ABSTRACT Objective: To verify the physiological action of triiodothyronine T3 on the expression of transforming growth factor α (TGFA) mRNA in MCF7 cells by inhibition of RNA Polymerase II and the MAPK/ERK pathway Materials and methods: The cell line was treated with T3 at a physiological dose (10...
Adenocarcinoma/genética,
Adenocarcinoma/metabolismo,
Neoplasias de la Mama/genética,
Neoplasias de la Mama/metabolismo,
Línea Celular Tumoral/metabolismo,
Regulación Neoplásica de la Expresión Génica/genética,
Sistema de Señalización de MAP Quinasas/genética,
Células MCF-7/metabolismo,
Proto-Oncogenes/genética,
ARN Mensajero/genética,
Factor de Crecimiento Transformador alfa/efectos de los fármacos,
Factor de Crecimiento Transformador alfa/genética,
Factor de Crecimiento Transformador alfa/metabolismo,
Triyodotironina/genética,
Triyodotironina/metabolismo,
Triyodotironina/farmacología
ABSTRACT Objective: To investigate the histological subtypes and mutational profiles of non-small cell lung cancer in Brazil, looking for correlations among histological subtypes, expression of anaplastic lymphoma kinase (ALK), EGFR mutation status, and programmed death-ligand 1 (PD-L1) expression. Met...
Adenocarcinoma/genética,
Adenocarcinoma/patología,
Quinasa de Linfoma Anaplásico/análisis,
Antígeno B7-H1/análisis,
Biopsia,
Brasil,
Carcinoma de Pulmón de Células no Pequeñas/genética,
Carcinoma de Pulmón de Células no Pequeñas/patología,
Genes erbB-1/genética,
Inmunohistoquímica,
Neoplasias Pulmonares/genética,
Neoplasias Pulmonares/patología,
Mutación,
Valores de Referencia,
Estudios Retrospectivos
