Carvalho, Sylene C.R.;
Vasconcelos, Luydson R.S.;
Fonseca, Leonardo da;
Carmo, Rodrigo F.;
Tomitão, Michele T.;
Aroucha, Dayse C.B.L.;
Pereira, Leila M.M.B.;
Stefano, José Tadeu;
Ribeiro-Júnior, Ulysses;
Oliveira, Claudia P.;
Carrilho, Flair J..
OBJECTIVE: The folate pathway is involved in hepatic carcinogenesis and angiogenesis. Polymorphisms in genes related to such processes, including methylene tetrahydrofolate reductase (MTHFR) and vascular endothelial growth factor (VEGF)] may play an important role in the development of hepatocellular car...
Sevoflurane (SEVO) is widely applied as an anesthetic, which exerts antitumor capacity in various cancers, including hepatocellular carcinoma (HCC). Previous studies indicated that long non-coding RNA KCNQ1 opposite strand/antisense transcript 1 (KCNQ1OT1) was upregulated, while microRNA-29a-3p (miR-29a-...
Sorafenib (SOR) resistance is still a significant challenge for the effective treatment of hepatocellular carcinoma (HCC). The mechanism of sorafenib resistance remains unclear. Several microRNAs (miRNAs) have been identified as playing a role in impairing the sensitivity of tumor cells to treatment. We ...
Carcinoma Hepatocelular/tratamiento farmacológico,
Carcinoma Hepatocelular/genética,
Línea Celular Tumoral,
Proliferación Celular,
Resistencia a Antineoplásicos,
Regulación Neoplásica de la Expresión Génica,
Neoplasias Hepáticas/tratamiento farmacológico,
Neoplasias Hepáticas/genética,
MicroARNs/genética,
Fosfohidrolasa PTEN/genética,
Fosfatidilinositol 3-Quinasas/metabolismo,
Transducción de Señal,
Sorafenib/farmacología,
Serina-Treonina Quinasas TOR
This study aimed to explore the prognostic role of dipeptidyl peptidase 4 (DPP4) expression in hepatocellular carcinoma (HCC). DPP4 expression was measured in formalin-fixed paraffin-embedded specimens that were gathered from 327 HCC patients. Immunohistochemistry analyses were utilized to examine DPP4 e...
Biomarcadores de Tumor,
Carcinoma Hepatocelular/genética,
Carcinoma Hepatocelular/metabolismo,
Carcinoma Hepatocelular/mortalidad,
Dipeptidil Peptidasa 4/metabolismo,
Estudios de Seguimiento,
Inmunohistoquímica,
Neoplasias Hepáticas/genética,
Neoplasias Hepáticas/metabolismo,
Neoplasias Hepáticas/mortalidad,
Recurrencia Local de Neoplasia,
Pronóstico,
Ensayos Antitumor por Modelo de Xenoinjerto
Abstract Long-chain non-encoded RNAs (lncRNAs) are important in many life activities and can participate in the occurrence of hepatocellular carcinoma (HCC). Moreover, lncRNAs can be used as basis for developing new strategies to hinder liver cancer. To investigate the utility of lncRNAs in HCC as potent...
Hepatocellular carcinoma (HCC) is one of the most common primary malignant tumors of the liver worldwide. Liver resection and transplantation are currently the only effective treatments; however, recurrence and metastasis rates are still high. Previous studies have shown that the epithelial-mesenchymal t...
Antineoplásicos/farmacología,
Antineoplásicos/uso terapéutico,
Carcinoma Hepatocelular/tratamiento farmacológico,
Carcinoma Hepatocelular/genética,
Proliferación Celular/efectos de los fármacos,
Proliferación Celular/genética,
Modelos Animales de Enfermedad,
Ensayos de Selección de Medicamentos Antitumorales,
Transición Epitelial-Mesenquimal/efectos de los fármacos,
Isoflavonas/farmacología,
Isoflavonas/uso terapéutico,
Neoplasias Hepáticas/tratamiento farmacológico,
Neoplasias Hepáticas/genética,
MicroARNs/genética,
Invasividad Neoplásica,
Fosfohidrolasa PTEN/genética,
Pirroles
Abstract INTRODUCTION: HPA polymorphism has been associated with HCV presence and fibrosis progression in chronic hepatitis C. However, it is unknown if there is an association between HPA-1 polymorphism and hepatocellular carcinoma (HCC). Therefore, this study aimed to evaluate HPA-1 polymorphism in t...
Antígenos de Plaqueta Humana/genética,
Carcinoma Hepatocelular/genética,
Carcinoma Hepatocelular/virología,
Progresión de la Enfermedad,
Marcadores Genéticos,
Genotipo,
Hepatitis C Crónica/genética,
Hepatitis C Crónica/virología,
Neoplasias Hepáticas/genética,
Neoplasias Hepáticas/virología,
Persona de Mediana Edad,
Reacción en Cadena de la Polimerasa,
Pronóstico,
Factores de Riesgo
The long non-coding RNA (lncRNA) maternally expressed gene 3 (MEG3), a tumor suppressor, is critical for the carcinogenesis and progression of different cancers, including hepatocellular carcinoma (HCC). To date, the roles of lncRNA MEG3 in HCC are not well illustrated. Therefore, this study used western...
Apoptosis/genética,
Carcinoma Hepatocelular/genética,
Carcinoma Hepatocelular/metabolismo,
Carcinoma Hepatocelular/patología,
Línea Celular Tumoral,
Proliferación Celular/genética,
Regulación Neoplásica de la Expresión Génica,
Neoplasias Hepáticas/genética,
Neoplasias Hepáticas/metabolismo,
Neoplasias Hepáticas/patología,
MicroARNs/genética,
MicroARNs/metabolismo,
Estadificación de Neoplasias,
ARN Largo no Codificante/genética,
ARN Largo no Codificante/metabolismo,
Reacción en Cadena en Tiempo Real de la Polimerasa,
Factores de Transcripción SOXC/genética,
Factores de Transcripción SOXC/metabolismo,
Activación Transcripcional,
Transfección,
Regulación hacia Arriba
An abnormality in the Lin28/let-7a axis is relevant to the progression of hepatitis B virus (HBV)-positive hepatocellular carcinoma (HCC), which could be a novel therapeutic target for this malignant tumor. The present study aimed to investigate the antiproliferative and anti-invasive effects of urolithi...
Análisis de Varianza,
Western Blotting,
Carcinoma Hepatocelular/tratamiento farmacológico,
Carcinoma Hepatocelular/genética,
Carcinoma Hepatocelular/virología,
Proliferación Celular/efectos de los fármacos,
Supervivencia Celular/efectos de los fármacos,
Cumarinas/farmacología,
Células Hep G2,
Neoplasias Hepáticas/tratamiento farmacológico,
Neoplasias Hepáticas/genética,
Neoplasias Hepáticas/virología,
MicroARNs/análisis,
MicroARNs/efectos de los fármacos,
Proteínas de Unión al ARN/análisis,
Proteínas de Unión al ARN/efectos de los fármacos,
Reacción en Cadena en Tiempo Real de la Polimerasa,
Valores de Referencia,
Reproducibilidad de los Resultados,
Sincalida/análisis,
Factores de Tiempo,
Replicación Viral/efectos de los fármacos
