Abstract EphrinB2 plays a critical role in tumor growth. In this study, we studied the antitumor activity of imperatorin derivative IMP-1 in renal cell carcinoma (RCC) by regulating EphrinB2 pathway.. Results showed that IMP-1 inhibited the proliferation of 786-O cells in a dose- and time-dependent manne...
Oral squamous cell carcinoma (OSCC) is one of the most well-known malignancies that affect the human population worldwide. The early diagnosis and early intervention of OSCC help improve the survival rate of the patients. The tumour free surgical margins are a positive prognostic factor for recurrence-fr...
This study investigated the mechanism underlying the suppression of estrogen receptor-positive MCF-7 cell growth by regorafenib. MCF-7 cells were treated with regorafenib, and the effect of regorafenib on multiple cancer-associated pathways was evaluated. Although regorafenib effectively inhibited the pr...
ABSTRACT Background : It is believed that the Wnt pathway is one of the most important signaling involved in gastric carcinogenesis. Aim : To analyze the protein expression of canonical and non-canonical Wnt pathways in gastric carcinoma. Method : The immunohistochemistry was performed in 72 specimen...
Proteína Axina/análisis,
Carcinogénesis,
Carcinoma/química,
Carcinoma/patología,
Quinasa de la Caseína I/análisis,
Ciclina D1/análisis,
Receptores Frizzled/análisis,
Glucógeno Sintasa Quinasa 3 beta/análisis,
Inmunohistoquímica,
Proteínas de Neoplasias/análisis,
Estadificación de Neoplasias,
Proteínas Proto-Oncogénicas c-myc/análisis,
Valores de Referencia,
Neoplasias Gástricas/química,
Neoplasias Gástricas/patología,
Ubiquitina/análisis,
Vía de Señalización Wnt,
Proteína Wnt-5a/análisis
Chen, Tingting;
Wang, Yong;
Yang, Yang;
Yu, Kaikai;
Cao, Xiangliao;
Su, Fang;
Xu, Huanbai;
Peng, Yongde;
Hu, Yudong;
Qian, Feng;
Wang, Zishu.
BACKGROUND: Gastric cancer is a common malignant tumor with high morbidity and mortality worldwide, which seriously affects human health. Gramicidin is a short peptide antibiotic which could be used for treating infection induced by bacteria or fungi. However, the anti-cancer effect of gramicidin on gast...
Apoptosis/efectos de los fármacos,
Ciclo Celular/efectos de los fármacos,
Movimiento Celular/efectos de los fármacos,
Proliferación Celular/efectos de los fármacos,
Gramicidina/farmacología,
Neoplasias Gástricas/patología,
Ciclina D1/efectos de los fármacos,
Ciclina D1/metabolismo,
Proteína Forkhead Box O1/efectos de los fármacos,
Proteína Forkhead Box O1/metabolismo,
Proteínas Proto-Oncogénicas c-bcl-2/efectos de los fármacos,
Proteínas Proto-Oncogénicas c-bcl-2/metabolismo,
Línea Celular Tumoral,
Regulación hacia Abajo,
Fosforilación
O câncer de boca ocupa uma posição de destaque em relação ao número total de casos registrados no Brasil. A displasia epitelial (DE) oral é um achado histopatológico associado a um risco aumentado de transformação maligna do epitélio oral. A falha nos mecanismos de sinalização celular, no co...
Background: Cyclin D1 is a protein essential for transition from G1 to S phase during cell cycle progression, which has an oncogenic potential and is highly expressed in several human malignancies. However, in view of the heterogeneity of the findings in the literature, the prognostic value of cyclin D1 ...
Um dos objetivos da pesquisa científica, atualmente, é encontrar biomarcadores que possam auxiliar na definição da probabilidade de progressão das lesões orais displásicas, e ainda sejam capazes de identificar os principais agentes moleculares envolvidos na carcinogênese de um determinado tipo de...
Estudios de Casos y Controles,
Carcinoma de Células Escamosas/patología,
Neoplasias de los Labios/patología,
Queilitis/patología,
beta Catenina/análisis,
Ciclina D1/análisis,
Biomarcadores de Tumor/análisis,
Mucosa Bucal/patología,
Inmunohistoquímica,
Estadísticas no Paramétricas,
Valores de Referencia,
Reproducibilidad de los Resultados,
Pronóstico
Geng, Wenjia;
Wei, Ribao;
Liu, Shuwen;
Tang, Li;
Zhu, Hanyu;
Chen, Pu;
Wu, Jie;
Zhang, Xueguang;
Zhu, Fei;
Yin, Zhong;
Chen, Xiangmei.
BACKGROUND: In China, mesangial proliferative glomerulonephritis (MsPGN) is one of the most common kidney diseases. In this study, we treated a rat model of chronic anti-Thy-1 MsPGN with Shenhua Tablet and evaluated whether the tablet was able to protect the kidney function. Thirty-six Wistar rats were r...
Proliferación Celular/efectos de los fármacos,
Medicamentos Herbarios Chinos/farmacología,
Glomerulonefritis Membranoproliferativa/tratamiento farmacológico,
Células Mesangiales/efectos de los fármacos,
Isoanticuerpos,
Ciclina D1/análisis,
Medicamentos Herbarios Chinos/uso terapéutico,
Glomerulonefritis Membranoproliferativa/patología,
Proteína Quinasa 1 Activada por Mitógenos/análisis,
Albúmina Sérica/análisis,
Quinasas p21 Activadas/análisis,
Enfermedad Crónica,
Ratas Wistar,
Reproducibilidad de los Resultados,
Computadoras de Mano,
Factores de Tiempo
BACKGROUND: The aberrant expression of microRNAs (miRNAs) has been found in various types of cancer. miR-205 was reported to be upregulated in laryngeal squamous cell carcinoma (LSCC) tissues, however, the mechanisms by which miR-205 functions as a regulator of LSCC are largely unknown. RESULTS: In this ...
Carcinoma de Células Escamosas/patología,
Proliferación Celular/genética,
Neoplasias Laríngeas/patología,
MicroARNs/genética,
Supresión Genética/genética,
Proteínas Supresoras de Tumor/genética,
Carcinoma de Células Escamosas/enzimología,
Ciclina D1/metabolismo,
Genes myc/genética,
Metaloproteinasa 2 de la Matriz/metabolismo,
Metaloproteinasa 9 de la Matriz/metabolismo,
MicroARNs/metabolismo,
Invasividad Neoplásica/genética,
Proteínas Supresoras de Tumor/metabolismo,
Biomarcadores de Tumor,
Western Blotting,
Regulación hacia Abajo,
Regulación Neoplásica de la Expresión Génica,
Células Hep G2,
Cultivo Primario de Células,
Reacción en Cadena en Tiempo Real de la Polimerasa
