Purpose: To explore the protection of naringenin against oxygen-glucose deprivation/reperfusion (OGD/R)-induced HT22 cell injury, a cell model of cerebral ischemia/reperfusion (I/R) injury in vitro, focusing on SIRT1/FOXO1 signaling pathway. Methods: Cytotoxicity, apoptosis, reactive oxygen species (ROS)...
Introduction:
Myocardial ischemia-reperfusion (I/R) injury is one of the mechanisms contributing to the high mortality rate of acute myocardial infarction.
Purpose:
This study intended to study the role of naringin in cardiac I/R injury.
Methods:
AC16 cells (human cardiomyocyte cell line) were subjecte...
Abstract Naringin has been shown to exhibit satisfying iron chelation capacity. Considering the side effects of routinely-used iron chelator (desferrioxamine, DFO), we decided to evaluate the iron chelation potency of naringin to discover whether or not it can be a promising natural substitute for treat...
Abstract Ischemia/reperfusion (IR) injury leads to overproduction of Reactive Oxygen Species (ROS), and disrupts membrane potential that contributes to cell death. The aim of this study was to determine if naringin (NAR), trimetazidine (TMZ) or their combination, protect the kidney mitochondrial from IR ...
Ainda não foi encontrado um medicamento capaz de desinfetar os canais radiculares e permitir a recuperação celular e a regeneração tecidual em dentes permanentes jovens com comprometimento endodôntico. Dois importantes flavonóis detectados no vinho tinto, morina (MO) e miricetina (MY), são atualm...
Irrigantes del Conducto Radicular,
d0001900,
d0008900,
d0184410,
d0584910,
d0037860,
d0132930,
d0169670,
d0201000,
d0482710,
d0132950,
d0149200,
Flavonoles,
Flavanonas,
Flavonoides,
Odontoblastos,
Supervivencia Celular,
Fosfatasa Alcalina,
Flavonoides/toxicidad,
Flavonoles/toxicidad
Lophophytum species are holoparasites that grow on tree roots. The objectives of the work were to explore the chemical composition of the tubers of two Lophophytum species and to analyze the antioxidant, anti-inflammatory and antilithiatic activity of their extracts using in vitro methods. The chemical ...
Balanophoraceae/química,
Antioxidantes/química,
Antiinflamatorios/química,
Extractos Vegetales/química,
Extractos Vegetales/farmacología,
Antioxidantes/farmacología,
Antiinflamatorios/farmacología,
Cromatografía Líquida de Alta Presión,
Espectrometría de Masas en Tándem,
Compuestos Fenólicos/análisis,
Flavanonas/análisis,
Flavonas/análisis
Resumo Fundamento: O núcleo do trato solitário (NTS) é uma área do cérebro que desempenha um papel fundamental na regulação renal e cardiovascular através dos impulsos dos barorreceptores. Objetivos: O objetivo deste estudo foi avaliar o efeito da Naringina (NAR) e trimetazidina (TMZ), isoladam...
A perda óssea dentária e a formação de lesões periapicais surgem como uma consequênc ia do desequilíbrio da homeostase óssea. Os osteoblastos, juntamente com os osteoclastos e osteócitos, atuam na formação e na reabsorção óssea. Vários marcadores de formação óssea são produzidos por os...
Periodontitis Periapical,
Flavonoides,
Homeostasis,
Huesos,
Osteoblastos,
Osteocitos,
Quercetina,
Resorción Ósea,
Remodelación Ósea,
Rutina,
Flavonoides/toxicidad,
Flavonoides/uso terapéutico,
Flavanonas,
Calcificación Fisiológica,
Osteoclastos
Naringenin (NAR) is a major flavanone in citrus fruits that has multiple pharmacological attributes such as anticancer and antiatherogenic. This study aims to investigate the mechanism of NAR in high-fat-diet (HFD)-induced atherosclerosis (AS) in apolipoprotein E-knockout (ApoE-/-) mice. A HFD-induced AS...
