SUMMARY: We aimed to investigate the protective effect of linoleic acid on liver toxicity induced by methotrexate. The study was carried out in partnership with the Department of Anatomy and Department of Medical Pharmacology of Çukurova University Faculty of Medicine, using the laboratory facilities of...
Enfermedad Hepática Inducida por Sustancias y Drogas/prevención & control,
Ácido Linoleico/administración & dosificación,
Metotrexato/toxicidad,
Hepatocitos/efectos de los fármacos,
Sustancias Protectoras,
Hígado/efectos de los fármacos,
Ensayo de Inmunoadsorción Enzimática,
Células Cultivadas,
Hígado/citología,
Factor Inductor de la Apoptosis,
Chaperón BiP del Retículo Endoplásmico,
Caspasa 3,
Enfermedad Hepática Inducida por Sustancias y Drogas/tratamiento farmacológico,
Antimetabolitos Antineoplásicos/toxicidad
ABSTRACT Dengue has been a significant public health problem in Colombia since the simultaneous circulation of the four dengue virus serotypes. The replicative fitness of dengue is a biological feature important for virus evolution and contributes to elucidating the behavior of virus populations and vira...
Línea Celular,
Supervivencia Celular,
Células Cultivadas,
Colombia,
Virus del Dengue/genética,
Virus del Dengue/patogenicidad,
Citometría de Flujo,
Formazáns,
Hígado/citología,
ARN Viral/genética,
Valores de Referencia,
Reacción en Cadena de la Polimerasa de Transcriptasa Inversa,
Serogrupo,
Sales de Tetrazolio,
Factores de Tiempo,
Ensayo de Placa Viral,
Replicación Viral/genética
Abstract Purpose: To establish a method for the preparation of zoledronate liposome and to observe its effect on inducing the apoptosis of rat liver Kupffer cells. Methods: Zoledronate was encapsulated in liposomes, and then the entrapment rate was detected on a spectrophotometer. The prepared Zoledro...
Apoptosis/efectos de los fármacos,
Recuento de Células,
Composición de Medicamentos/métodos,
Citometría de Flujo,
Inmunohistoquímica,
Macrófagos del Hígado/efectos de los fármacos,
Liposomas/síntesis química,
Hígado/citología,
Distribución Aleatoria,
Ratas Sprague-Dawley,
Reproducibilidad de los Resultados,
Resultado del Tratamiento,
Ácido Zoledrónico/administración & dosificación,
Ácido Zoledrónico/síntesis química,
Ácido Zoledrónico/farmacología
Histopathological evaluation of liver from 33 pigs slaughtered for human consumption in Amazon region, previously tested by serology and molecular techniques for hepatitis E virus infection (HEV), was analysed in three groups: Group 1, negative for both HEV-RNA and anti-HEV IgG (n=10); Group 2, positive ...
Nuclear factor erythroid-related factor 2 (Nrf2) has been implicated in several detoxifying and antioxidant defense processes. Nrf2-mediated heme oxygenase-1 (HO-1) expression was demonstrated to play a key role against oxidative stress. Gastrodin (GSTD) is a well-known active compound isolated from the ...
Apoptosis/efectos de los fármacos,
Alcoholes Bencílicos/farmacología,
Supervivencia Celular/efectos de los fármacos,
Células Endoteliales/efectos de los fármacos,
Glucósidos/farmacología,
Hemo-Oxigenasa 1/metabolismo,
Peróxido de Hidrógeno/farmacología,
Hígado/citología,
Hígado/efectos de los fármacos,
Malondialdehído/metabolismo,
Modelos Teóricos,
Regulación hacia Arriba/efectos de los fármacos,
Proteínas Quinasas p38 Activadas por Mitógenos/metabolismo
SUMMARY: Ghrelin is the endogenous ligand for the growth hormone secretagogue receptor, and has been found in the liver of multiple vertebrates. While ghrelin has been identified in the gastrointestinal tract of African ostrich chicks, little is known regarding its distribution in the liver of the Africa...
ABSTRACT Introduction and aim. The inability to distinguish cancer (CSCs) from normal stem cells (NSCs) has hindered attempts to identify safer, more effective therapies for hepatocellular carcinoma (HCC). The aim of this study was to document and compare cell membrane potential differences (PDs) of CS...
Carcinoma Hepatocelular/metabolismo,
Neoplasias Hepáticas/metabolismo,
Hígado/citología,
Células Madre Neoplásicas/metabolismo,
Receptores de GABA-A/metabolismo,
Carcinoma Hepatocelular/genética,
Molécula de Adhesión Celular Epitelial/metabolismo,
Agonistas de Receptores de GABA-A/farmacología,
Biomarcadores/metabolismo,
Técnica del Anticuerpo Fluorescente,
Separación Inmunomagnética,
Neoplasias Hepáticas/genética,
Potenciales de la Membrana/efectos de los fármacos,
Células Madre Neoplásicas/efectos de los fármacos,
Fenotipo,
Subunidades de Proteína,
ARN Mensajero/genética,
ARN Mensajero/metabolismo,
Receptores de GABA-A/efectos de los fármacos,
Receptores de GABA-A/genética,
Reacción en Cadena de la Polimerasa de Transcriptasa Inversa,
Células Madre/efectos de los fármacos
Regarding the importance of starvation and refeeding and the occurrence of refeeding syndrome in various conditions, the present study was conducted to investigate the effects of refeeding on some parameters of energy metabolism and electrolytes and changes of hepatic tissue in male Wistar rats. Fifty-se...
Trindade, A. B;
Beck, C. A. C;
Ataíde, M. W;
Schiochet, F;
Gerardi, D. G;
Brun, M. V;
Driemeier, D;
Zlotowski, P;
Cardoso, M. R. I;
Cirne-Lima, E. O;
Contesini, E. A.
A cirurgia endoscópica por orifícios naturais (NOTES) representa um novo conceito de cirurgia, caracterizada por ausência de incisões abdominais. Os acessos mais comumente usados são o transvaginal e o transgástrico. Entretanto, as rotas transcolônica e transretal representam alternativas promisso...
The liver is a widely researched organ for having an infinity of functions. On the other hand, Stereologyallows the access of quantitaive data of the study´s structure. Having access to this tpe of date of hepatocitos and sinusoids Under normal physiological conditions, it is necessary to determine how ...
