Abstract Hemochromatosis is currently characterized by the iron overload caused by hepcidin deficiency. Large advances in the knowledge on the hemochromatosis pathophysiology have occurred due to a better understanding of the protein of the iron metabolism, the genetic basis of hemochromatosis and of oth...
ABSTRACT Introduction: Glomerular hyperfiltration may lead to proteinuria and chronic kidney disease in unilateral multicystic dysplastic kidney (MCDK). We aimed to investigate the urine neutrophil-gelatinase-associated lipocalin (NGAL), netrin-1, hepcidin, and C-C motif chemokine ligand-2 (MCP-1/CCL-2)...
SUMMARY BACKGROUND Hepcidin is an important regulator of iron homeostasis. OBJECTIVES This cross-sectional study was conducted to evaluate the association between hepcidin and components of metabolic syndrome in patients with chronic kidney disease (CKD). DESIGN AND SETTING 103 CKD patients and 59 ...
ABSTRACT Background: Recently, a small peptide called Hepcidin, was found to have an important role in regulating the iron metabolism in anemia of chronic disease (ACD) patients. Hepcidin is regulated by a variety of conditions at the transcriptional level. Therefore, our study aims to predict the level...
Leite, Sandra Augusta de Moura;
Casanovas, Rosana Costa;
Rodrigues, Vandilson Pinheiro;
Pereira, Adriana de Fátima Vasconcelos;
Ferreira, Teresa Cristina Alves;
Nascimento, Flávia Raquel Fernandes do;
Nascimento, Johnny Ramos do;
Gomes-Filho, Isaac Suzart;
Bastos, Marcus Gomes;
Pereira, Antonio Luiz Amaral.
Abstract Serum hepcidin levels may increase in response to infection and inflammation. The present study investigated the effect of nonsurgical periodontal therapy (NSPT) on levels of serum hepcidin, inflammatory markers, and iron markers. An interventional study was conducted on 67 patients (age 30-65 y...
Biomarcadores/sangre,
Proteína C-Reactiva/análisis,
Estudios de Casos y Controles,
Periodontitis Crónica/sangre,
Periodontitis Crónica/patología,
Periodontitis Crónica/terapia,
Índice de Placa Dental,
Encía/patología,
Hepcidinas/sangre,
Interleucina-6/sangre,
Hierro/sangre,
Persona de Mediana Edad,
Pérdida de la Inserción Periodontal/sangre,
Pérdida de la Inserción Periodontal/patología,
Valores de Referencia,
Aplanamiento de la Raíz/métodos,
Estadísticas no Paramétricas,
Factores de Tiempo,
Resultado del Tratamiento
En las últimas décadas se ha avanzado en el conocimiento de la regulación del metabolismo del Hierro (Fe). La Hepcidina (Hp), producida por los hepatocitos, regula la absorción de hierro desde el tubo digestivo y la liberación desde los depósitos del sistema macrofágico y del hígado. En caso de d...
El eje hepcidina-ferroportina es determinante en la homeostasis del hierro. Niveles elevados de hepcidina reducen la capacidad de absorción intestinal del hierro, así como su movilización entre tejidos. Una condición que produce valores séricos elevados de hepcidina es la infección. Como la infecci...
Handa, Priya;
Maliken, Bryan D;
Nelson, James E;
Hennessey, Kelly A;
Vemulakonda, L. Akhila;
Morgan-Stevenson, Vicki;
Dhillon, Barjinder K;
Gupta, Rohit;
Yeh, Matthew M;
Kowdley, Kris V.
Abstract: Nonalcoholic fatty liver disease (NAFLD) is the most common cause of chronic liver disease worldwide. We have previously shown that hepatic reticuloendothelial system (RES) iron deposition is associated with an advanced degree of nonalcoholic steatohepatitis (NASH) in humans. In this study, we ...
Inflamación/genética,
Sobrecarga de Hierro/genética,
Hierro/análisis,
Hígado/química,
Enfermedad del Hígado Graso no Alcohólico/genética,
Estrés Oxidativo/genética,
Regulación de la Expresión Génica,
Hepcidinas/genética,
Inflamación/sangre,
Inflamación/diagnóstico,
Mediadores de Inflamación/sangre,
Interleucina-1beta/sangre,
Interleucina-1beta/genética,
Sobrecarga de Hierro/sangre,
Sobrecarga de Hierro/diagnóstico,
Hígado/patología,
Proteínas de la Membrana/genética,
Enfermedad del Hígado Graso no Alcohólico/sangre,
Enfermedad del Hígado Graso no Alcohólico/diagnóstico,
Reacción en Cadena en Tiempo Real de la Polimerasa,
Factor de Transcripción STAT3/genética,
Serina Endopeptidasas/genética,
Factor de Necrosis Tumoral alfa/sangre,
Factor de Necrosis Tumoral alfa/genética
Abstract Anemia is a common complication and its impact on morbimortality in patients with chronic kidney disease (CKD) is well known. The discovery of hepcidin and its functions has contributed to a better understanding of iron metabolism disorders in CKD anemia. Hepcidin is a peptide mainly produced by...
Background Hepcidins, a kind of cysteine-rich antimicrobial peptides, play important roles in host immunological processes and iron regulation, which have been identified from several fish species. The rare minnow (Gobiocypris rarus), an endemic cyprinid fish in China, has been used extensively as model ...
