Results: 11

Increased Expression of Type-I Collagen in Malignant Colorectal Lesion and Positive Correlations with Clinical Factors

Abstract Objective Type-I collagen (Col-I) is one of the main macromolecules of the extracellular matrix, and it is involved in the desmoplastic stromal reaction, an indicator of worse prognosis in cases of colorectal cancer (CRC). The purpose of the present study was to investigate Col-I expression in...

Comparação dos meios de preparação e preservação de membrana amniótica humana para uso no tratamento de doenças da superfície ocular

Rev. bras. oftalmol; 79 (1), 2020
Resumo Atualmente a membra amniótica (MA) tem obtido importância devido à comprovada capacidade de reduzir inflamação, auxiliar a cicatrização e epitelização, possuindo propriedades antimicrobianas e antivirais, além de baixa imunogenicidade. As indicações de seu uso na oftalmologia têm aume...

Toxoplasma gondii infection damages the perineuronal nets in a murine model

Mem. Inst. Oswaldo Cruz; 115 (), 2020
BACKGROUND Behavioral and neurochemical alterations associated with toxoplasmosis may be influenced by the persistence of tissue cysts and activation of an immune response in the brain of Toxoplasma gondii-infected hosts. The cerebral extracellular matrix is organised as perineuronal nets (PNNs) that ar...

Decellularization of human umbilical arteries

Int. j. morphol; 37 (1), 2019
SUMMARY: Arterial obstruction in small diameter (<6 mm) vessels are many times treated with grafts, however autologous aren't always available and synthetic have a high rate of complications. Decellularization of umbilical arteries may provide a solution, but the ideal method is debatable. We compare ...

Effect of cytoglobin overexpression on extracellular matrix component synthesis in human tenon fibroblasts

Biol. Res; 52 (), 2019
BACKGROUND: Conjunctival filtering bleb scar formation is the main reason for the failure of glaucoma filtration surgery. Cytoglobin (Cygb) has been reported to play an important role in extracellular matrix (ECM) remodeling, fibrosis and tissue damage repairing. This study aimed to investigate the role ...

Elastin increases biofilm and extracellular matrix production of Aspergillus fumigatus

Braz. j. microbiol; 49 (3), 2018
Abstract Aspergillus fumigatus is an opportunistic saprobe fungus that accounts for 90% of cases of pulmonary aspergillosis in immunosuppressed patients and is known for its angiotropism. When it reaches the respiratory tract, A. fumigatus interacts with structural components and blood vessels of the lun...

Alterations in the expression and activity of extracellular matrix components in HPV-associated infections and diseases

Clinics; 73 (supl.1), 2018
Infection with human papillomaviruses is associated with a series of benign and malignant hyperproliferative diseases that impose a heavy burden on human populations. A subgroup of mucosal human papillomavirus types are associated with the majority of cervical cancers and a relevant fraction of vulvar, v...

Papel da matriz colágena na funçäo diastólica ventricular: estudo em ratos submetidos a infusöes de glutationa oxidada

A remodelaçäo miocárdia é descrita como condiçäo na qual, tipicamente, ocorre aumento da concentraçäo do colágeno intersticial. Essa distorçäo da matriz intersticial é tida como causa de disfunçäo diastólica ventricular. A situaçäo inversa, isto é, quando há reduçäo da quantidade nor...