BACKGROUND: Contrary to the advantageous anticancer activities of curcumin (Cur), limited bioavailability and solubility hindered its efficacy. Here, nontoxic dendrosomal nano carrier with Cur was used to overcome these problems. Despite considerable antitumor properties of Oxaliplatin (Oxa), the limitin...
ABSTRACT Objective: to report the final analysis of a phase 2 trial assessing the efficacy and safety of short-course hyperthermic intraperitoneal chemotherapy (HIPEC) for patients with advanced epithelial ovarian cancer (EOC). Methods: this was an open-label, multicenter, single-arm trial of HIPEC i...
Background: Ovarian cancer is the most common gynecological malignancy. In patients with advanced ovarian cancer, some biological parameters have prognostic implementations. P27kip1 is an inhibitor of a cycline-dependent kinase, its loss, can contribute to tumor progression.
Objective: This study aimed t...
Resumen El cáncer de ovario se ha caracterizado por ser la neoplasia ginecológica de peor pronóstico. Lo anterior es consecuencia del curso silente de la enfermedad que ocasiona que la mayorÃa de las veces el diagnóstico se realice en etapas avanzadas. La información recolectada señala que los ava...
In this study, we aimed to analyze the anti-cancer effects of β-elemene combined with paclitaxel for ovarian cancer. RT-qPCR, MTT assay, western blot, flow cytometry, and immunohistochemistry were used to analyze in vitro and in vivo anti-cancer effects of combined treatment of β-elemene and pa...
Apoptosis/efectos de los fármacos,
Western Blotting,
LÃnea Celular Tumoral,
Movimiento Celular/efectos de los fármacos,
Proliferación Celular/efectos de los fármacos,
InmunohistoquÃmica,
Ratones Endogámicos BALB C,
FN-kappa B/efectos adversos,
FN-kappa B/metabolismo,
Neoplasias Ováricas/tratamiento farmacológico,
Neoplasias Ováricas/metabolismo,
Neoplasias Ováricas/patologÃa,
Paclitaxel/administración & dosificación,
Reacción en Cadena en Tiempo Real de la Polimerasa,
Sesquiterpenos/administración & dosificación,
Transducción de Señal,
Transfección
Abstract Objective The aim of the present study was to describe and analyze data of 57 women with borderline ovarian tumors (BOTs) regarding histological characteristics, clinical features and treatment management at the Department of Obstetrics and Gynecology of the Universidade Estadual de Campinas (...
Distribución por Edad,
Antineoplásicos/uso terapéutico,
Brasil,
Instituciones Oncológicas/estadÃstica & datos numéricos,
HisterectomÃa/estadÃstica & datos numéricos,
Menopausia/fisiologÃa,
Persona de Mediana Edad,
Recurrencia Local de Neoplasia/tratamiento farmacológico,
Recurrencia Local de Neoplasia/etiologÃa,
Recurrencia Local de Neoplasia/patologÃa,
Tratamientos Conservadores del Órgano/estadÃstica & datos numéricos,
Neoplasias Ováricas/tratamiento farmacológico,
Neoplasias Ováricas/patologÃa,
Neoplasias Ováricas/cirugÃa,
Lesiones Precancerosas/tratamiento farmacológico,
Lesiones Precancerosas/patologÃa,
Lesiones Precancerosas/cirugÃa,
Estudios Retrospectivos,
SalpingooforectomÃa/estadÃstica & datos numéricos,
Resultado del Tratamiento
Introdução: O câncer merece destaque entre as doenças que causam transtornos em adultos e crianças, pois continua sendo um diagnóstico dos mais temidos da atualidade. Vincula-se a um estigma de sofrimento, mutilação e morte, envolvendo uma série de ameaças e dificuldades, que afetam não só a ...
Quimioterapia/psicologÃa,
Juego e Implementos de Juego,
Neoplasias/tratamiento farmacológico,
Emociones,
Niño Hospitalizado/psicologÃa,
Leucemia-Linfoma Linfoblástico de Células Precursoras/tratamiento farmacológico,
Leucemia Mieloide Aguda/tratamiento farmacológico,
Neoplasias Renales/tratamiento farmacológico,
Neoplasias Ováricas/tratamiento farmacológico,
Conducta Infantil/psicologÃa,
Punciones/psicologÃa,
Infusiones Intravenosas/psicologÃa
The aim of this study was to evaluate the influence of artesunate on Th1 differentiation and its anti-tumor effect on ovarian cancer. A Murine ovarian cancer model was established by ID8 cells transplantation. The expression of miR-142 and Sirt1 proteins in peripheral CD4+ T cells were quantified with qR...
Antineoplásicos/farmacologÃa,
Antineoplásicos/uso terapéutico,
Apoptosis,
Artesunato/farmacologÃa,
Artesunato/uso terapéutico,
Linfocitos T CD4-Positivos/citologÃa,
Linfocitos T CD4-Positivos/efectos de los fármacos,
Diferenciación Celular,
Regulación hacia Abajo,
CitometrÃa de Flujo,
Ratones Endogámicos C57BL,
MicroARNs/metabolismo,
Neoplasias Ováricas/tratamiento farmacológico,
Neoplasias Ováricas/inmunologÃa,
Células TH1/citologÃa,
Células TH1/efectos de los fármacos
Benvenutti, Régis Carlos;
Gomes, Denise B;
Zanchet, Barbara;
Locateli, Gelvani;
Vechia, Cristian Alex Dalla;
Zanotelli Serpa, PatrÃcia;
Lutinski, Junir;
Rodrigues Junior, Sinval Adalberto;
Schönell, Amanda PatrÃcia;
Diel, Kriptsan Abdon Poletto;
Miorando, Daniela;
Ernetti, Jackeline;
Alves, Bianca de Oliveira;
Zilli, Gabriela Adriany Lisboa;
Banzato, Thais Petrochelli;
Ruiz, Ana Lúcia Tasca Gois;
Vidal Gutiérrez, Max;
Vilegas, Wagner;
Roman Junior, Walter Antônio.
Abstract Natural products, especially phytochemicals, have been extensively studies and have exhibited important antiproliferative effects. The American native species Urera baccifera (L.) Gaudich. ex Wedd. (Urticaceae) is widely distributed in Brazil, where it is known as urtiga-vermelha or urtigão. Th...
Introdução: Drogas antineoplásicas neurotóxicas estão frequentemente associadas à neuropatia periférica induzida por quimioterapia (NPIQ). Objetivo: Avaliar a evolução clÃnica dos pacientes expostos a tratamento antineoplásico potencialmente neurotóxico e identificar possÃveis preditores clÃ...
