Results: 22

Design and evaluation of ocular hydrogel containing combination of ofloxacin and dexamethasone for the treatment of conjunctivitis

Abstract Conjunctivitis is an inflammation of the conjunctiva, which covers the white part of the eyeball. It can be caused by allergies, bacterial or viral infection. In situ hydrogels are three-dimensional hydrophilic cross-linked network of polymers. In situ hydrogel provided better therapeutic index ...

Predictors of mortality in multidrug-resistant tuberculosis patients from Brazilian reference centers, 2005 to 2012

Braz. j. infect. dis; 22 (4), 2018
ABSTRACT Objectives To determine the main predictors of death in multidrug-resistant (MDRTB) patients from Brazil. Design Retrospective cohort study, a survival analysis of patients treated between 2005 and 2012. Results Of 3802 individuals included in study, 64.7% were men, mean age was 39 (1-93) yea...

Resistência de Neisseria gonorrhoeae a antimicrobianos na prática clínica: como está o Brasil?

Femina; 46 (2), 2018
Estima-se que um milhão de infecções sexualmente transmissíveis (IST) sejam adquiridas por dia no mundo, segundo a Organização Mundial da Saúde. Elas podem ser causadas por diversos micro-organismos pelo contato sexual. Embora tratáveis, as infecções, como a clamidiana, sífilis, tricomoníase ...

Utilização de lente de contato escleral na abordagem terapêutica da úlcera neurotrófica corneana

Rev. bras. oftalmol; 77 (2), 2018
Resumo Neste artigo descrevemos como conduzimos com sucesso um caso de úlcera neurotrófica não responsivo à terapia convencional com o uso de lente de contato escleral e as vantagens desta terapêutica....

Síntesis de nanopartículas de ácido poliláctico cargadas con antibióticos y su actividad antibacteriana contra Escherichia coli O157:H7 y Staphylococcus aureus resistente a meticilina

Biomédica (Bogotá); 37 (1), 2017
Resumen Introducción: Las nanopartículas poliméricas constituyen una herramienta nanotecnológica que podría ayudar a combatir los microorganismos patógenos que han desarrollado resistencia a los antibióticos convencionales. Objetivo: Sintetizar nanopartículas de ácido poliláctico cargadas con...

Penetration of 0. 3% ciprofloxacin, 0. 3% ofloxacin, and 0. 5% moxifloxacin into the cornea and aqueous humor of enucleated human eyes

Braz. j. med. biol. res; 50 (7), 2017
We aimed to quantify the penetration of ciprofloxacin, ofloxacin, and moxifloxacin into the cornea and aqueous humor of cadaver eyes. A total of 60 enucleated eyes, not eligible for corneal transplantation, were divided into three groups and immersed in commercial solutions of 0.3% ciprofloxacin, 0.3% of...

Development and evaluation of ofloxacin orally disintegrating tablets

Braz. j. pharm. sci; 48 (2), 2012
Bitter taste of ofloxacin, a broad spectrum bactericidal agent, is masked and orally disintegrating tablets were formulated. The bitter taste is masked by forming complex between drug and weak cation exchange resins, Tulsion 335 and Indion 204. Effect of pH and drug:resin ratio on the drug loading was st...

Study of the Nuclear Volume of Testicular Cells of Rats Receiving Ofloxacin Through Lactation

Int. j. morphol; 25 (3), 2007
Ofloxacin presents an ample spectrum of antimicrobial action, including combating Mycobacterium leprae, and is currently employed as a substitute when the use of rifampicin is impossible. The objective of this work was to study alterations in testicular cell nuclei of suckling rats, whose dams were submi...

Portación rinofaríngea de Neisseria meningitidis
Rhinopharyngeal carriage of Neisseria meningitidis

Neisseria meningitidis is an exclusively human, gram negative, bean - shaped pathogenic diplococcus. Cells are nonmotile and do not produce endospore. Neisseria meningitidis has complex growth requirements. It is an aerobic bacteria and its optimal growth temperature is 35ºC, require humidity and 2 to 8...

Avaliaçäo da bioequivalência de comprimidos contendo levofloxacino 500 mg produzidos por Apsen Farmacêutica S/A e Aventis Pharma. Etapas clínica, analítica e estatística
Bioequivalence evaluation of tablets containg levofloxacin 500mg produced by Apsen Pharmaceuticals S/A and Aventis Pahrma. Clinical, analytical and statystical steps

RBM rev. bras. med; 60 (7), 2003
Objetivos: Neste trabalho, se realizam etapas clínicas, analíticas e estatística de ensaio de bioequivalência em formulaçöes contendo levofloxacino produzidos por dois laboratórios farmacêuticos. Os objetivos foram: a) desenvolver e validar o método quantitativo (plasma); b) realizar ensaio clí...