SUMMARY: Diacylglycerol kinase (DGK) exerts balancing the intracellular level between two-second messengers, diacylglycerol and phosphatidic acid, by its phosphorylation activity. DGK ζ is often localized in cell nuclei, suggesting its involvement in the regulation of intranuclear activities, includ...
SUMMARY: Knowledge of the diameter of a structure or particle is required for stereological calculations. However, there is no consensus on the methodology for its measurement. This study aims to assess the differences between direct and indirect methods of measuring diameter. It is hypothesised that kid...
Abstract There are more than 150 different rare genetic kidney diseases. They can be classified according to diagnostic findings as (i) disorders of growth and structure, (ii) glomerular diseases, (iii) tubular, and (iv) metabolic diseases. In recent years, there has been a shift of paradigm in this fiel...
Enfermedad de Fabry/diagnóstico,
Enfermedad de Fabry/genética,
Enfermedad de Fabry/terapia,
Enfermedades Genéticas Congénitas/diagnóstico,
Enfermedades Genéticas Congénitas/genética,
Pruebas Genéticas/métodos,
Tasa de Filtración Glomerular/fisiología,
Pérdida Auditiva Sensorineural/diagnóstico,
Comunicación Interdisciplinaria,
Riñón/fisiopatología,
Enfermedades Renales/congénito,
Enfermedades Renales/diagnóstico,
Túbulos Renales/patología,
Enfermedades Metabólicas/patología,
Nefrología/normas,
Trombocitopenia/congénito,
Esclerosis Tuberosa/terapia,
Trombocitopenia/terapia,
Trombocitopenia/diagnóstico
Acetaminophen (also called paracetamol, or APAP) induced nephrotoxicity is reported after accidental or intentional ingestion of an overdose of the drug. Renal tubular ultrastructural alterations induced by APAP overdose associated with the induction of biomarkers of kidney injury have not been investiga...
Acetaminofén/toxicidad,
Túbulos Renales/efectos de los fármacos,
Resveratrol/administración & dosificación,
Resveratrol/farmacología,
Quercetina/administración & dosificación,
Quercetina/farmacología,
Modelos Animales de Enfermedad,
Sobredosis de Droga,
Ratas Sprague-Dawley,
Microscopía Electrónica de Transmisión,
Antioxidantes/administración & dosificación,
Antiinflamatorios/administración & dosificación,
Urea/sangre,
Creatinina/sangre,
Túbulos Renales/patología
Abstract Introduction: Acute kidney injury (AKI) occurs in about 22% of the patients undergoing cardiac surgery and 2.3% requires renal replacement therapy (RRT). The current diagnostic criteria for AKI by increased serum creatinine levels have limitations and new biomarkers are being tested. Urine sedi...
Lesión Renal Aguda/diagnóstico,
Lesión Renal Aguda/epidemiología,
Lesión Renal Aguda/etiología,
Lesión Renal Aguda/orina,
Biomarcadores/orina,
Procedimientos Quirúrgicos Cardíacos/efectos adversos,
Procedimientos Quirúrgicos Cardíacos/métodos,
Puente Cardiopulmonar/efectos adversos,
Creatinina/sangre,
Creatinina/orina,
Diagnóstico Precoz,
Células Epiteliales/patología,
Túbulos Renales/patología,
Microscopía de Contraste de Fase/métodos,
Portugal/epidemiología,
Complicaciones Posoperatorias/diagnóstico,
Complicaciones Posoperatorias/orina,
Estudios Prospectivos
ABSTRACT Objective: Urinary stones with oxalate composition can cause kidney failure. Recent findings evidenced that probiotics are effective in reducing oxalate absorption in these subjects based on their high colonic absorption levels at baseline. The purpose of this study was to evaluate the effect o...
Nitrógeno de la Urea Sanguínea,
Calcio/análisis,
Creatinina/análisis,
Hiperoxaluria/prevención & control,
Cálculos Renales/prevención & control,
Cálculos Renales/orina,
Túbulos Renales/química,
Oxalatos/orina,
Extractos Vegetales/farmacología,
Probióticos/farmacología,
Ratas Wistar,
Valores de Referencia,
Reproducibilidad de los Resultados,
Factores de Tiempo,
Tribulus/química,
Urtica dioica/química
SUMMARY: Titanium dioxide nanoparticles (TiO2 NPs) are widely used in many commercial products, nanomedicine, agriculture, personal care products, different industries and pharmaceutical preparations with potential risk in human health and the environment. The current work was conducted to investigate th...
Ginsenoside Rg1, one of the most notable active components of Panax ginseng, has been widely reported to exert anti-inflammatory actions. This study aimed to reveal whether ginsenoside Rg1 also exhibits beneficial roles against lipopolysaccharide (LPS)-induced apoptosis and inflammation in human renal tu...
Análisis de Varianza,
Antiinflamatorios/farmacología,
Apoptosis/efectos de los fármacos,
Western Blotting,
Línea Celular,
Ensayos de Migración Celular,
Supervivencia Celular/efectos de los fármacos,
Citocinas/análisis,
Citocinas/efectos de los fármacos,
Ensayo de Inmunoadsorción Enzimática,
Células Epiteliales/efectos de los fármacos,
Ginsenósidos/farmacología,
Túbulos Renales/citología,
Lipopolisacáridos,
Reproducibilidad de los Resultados
OBJECTIVES: Henoch-Schönlein purpura nephritis and immunoglobulin A nephropathy are two diseases with similar clinical presentations but very different prognoses. Transforming growth factor β1 and monocyte chemoattractant protein-1 have been associated with the development of tissue fibrosis. We ex...
HIV infection has different clinical presentations. We report a 21-year-old male with longstanding isolated microscopic hematuria attributed to thin glomerular basement membrane disease, who after 15 years of follow-up presented with significant proteinuria. A kidney biopsy was performed, revealing the p...
