SUMMARY: Letrozole is mainly used for the treatment of unexplained infertility, breast cancer and polycystic ovarian syndrome, with secondary use in ovarian stimulation. In cases of unexpected or unknown pregnancy during the use of letrozole, letrozole may cause a teratogenic effect on the fetus. In this...
Desarrollo Óseo/efectos de los fármacos,
Osteogénesis/efectos de los fármacos,
Teratógenos/farmacología,
Letrozol/farmacología,
Letrozol/efectos adversos,
Antineoplásicos/farmacología,
Antineoplásicos/efectos adversos,
Inmunohistoquímica,
Ratas Wistar,
Coloración y Etiquetado/métodos,
Desarrollo Fetal/efectos de los fármacos
SUMMARY: The postmortem diagnosis of death by drowning is one of the most difficult issues in forensic pathology. We investigated possible evidence differentiating saltwater drowning from freshwater drowning by histopathological changes in brain, heart, lungs, liver, and kidneys tissues. A cross section ...
SUMMARY: Peripheral nerve damage (PNI) can cause demyelination, axonal degeneration and loss of motor and sensory function. Melatonin with its antioxidative effect, has been reported to reduce scar formation in nerve injury, take a role in repair process by suppressing fibroblast proliferation in the dam...
Tibia/patología,
Enfermedades del Sistema Nervioso Periférico/tratamiento farmacológico,
Tibia/inervación,
Melatonina/administración & dosificación,
Antioxidantes/administración & dosificación,
Modelos Animales de Enfermedad,
Ratas Wistar,
Proteínas S100,
Factor A de Crecimiento Endotelial Vascular,
Nervios Periféricos/efectos de los fármacos,
Fibroblastos
SUMMARY: Knowledge of the diameter of a structure or particle is required for stereological calculations. However, there is no consensus on the methodology for its measurement. This study aims to assess the differences between direct and indirect methods of measuring diameter. It is hypothesised that kid...
RESUMEN: El cuerpo calloso (CC), es la mayor comisura de sustancia blanca del encéfalo de los mamíferos placentados, constituida por numerosos haces de fibras transversales que conectan áreas corticales de ambos hemisferios cerebrales. Por otro lado, el estrés se define como una respuesta general del...
SUMMARY: Cisplatin is a chemotherapeutic agent inducing liver and kidney damage. In this study, we intended to investigate the impact of kefir beverage, an essential probiotic and functional food, on liver and kidney damage induced by cisplatin. Wistar albino rats were divided into four groups: Control, ...
Cisplatino/toxicidad,
Antineoplásicos/toxicidad,
Riñón/efectos de los fármacos,
Hígado/efectos de los fármacos,
Kéfir,
Ratas Wistar,
Inmunohistoquímica,
Urea/análisis,
Creatinina/análisis,
Apoptosis/efectos de los fármacos,
Alanina Transaminasa/análisis,
Aspartato Aminotransferasas/análisis,
Caspasa 3
Abstract In the present study, free interstitial levels reached by metformin in the liver were investigated in control and diabetic rats by microdialysis. Firstly, a bioanalytical method using an HPLC-UV system to determine the drug concentration in microdialysis samples was validated. The blood glucose ...
Wang, Meng-Meng;
Hao, Gang;
Qu, Yu-Chen;
Chen, Li;
Hua, Wen-Yan;
Zong, Shun-Lin;
Wang, Meng;
Su, Cun-Jin;
Zhang, Quan-Ying;
Du, Zi-Yan;
Yu, Yun-Li.
Abstract Fluoroquinolones are an important class of antimicrobial agents to manage infectious diseases. However, knowledge about how host bile acids are modified by fluoroquinolones is limited. We investigated and compared the impact of fluoroquinolones on circulating bile acid profiles and gut microbiot...
Estudio Comparativo,
Ciprofloxacina/análisis,
Moxifloxacino/análisis,
Microbioma Gastrointestinal,
Antiinfecciosos/farmacología,
Cromatografía Líquida de Alta Presión/métodos,
Interacciones Hidrofóbicas e Hidrofílicas,
Intestino Grueso/anomalías,
Ratas Wistar,
Secuenciación de Nucleótidos de Alto Rendimiento,
Ácidos y Sales Biliares
O objetivo deste trabalho foi analisar o potencial bioativo de um “scaffold” de Polidioxanona (PDO) com associação da rhBMP-2, nas reconstruções após simulação de ressecção óssea em fêmures de ratos. Para tanto, 24 ratos, machos, adultos, com 6 meses de idade, foram submetidos a ressecçã...
Objetivo: comparar a neoformação óssea em defeitos críticos confeccionados em calvárias de ratos utilizando duas apresentações de membranas de colágeno porcino, Bio-Gide® e Ossix Plus® para o recobrimento da loja cirúrgica criada. Material e Método: trinta e dois ratos machos (Rattus novergic...
