ABSTRACT Objective To analyze respiratory mechanics and hemodynamic alterations in an experimental model of chronic heart failure (CHF) following myocardial infarction. Method Twenty-seven male adult Wistar rats were randomized to CHF group (n=12) or Sham group (n=15). Ten weeks after coronary ligation...
ABSTRACT Purpose: To evaluate lenticular oxidative stress in rat menopausal models. Methods: Forty Wistar female albino rats were included in this study. A total of thirty rats underwent oophorectomy to generate a menopausal model. Ten rats that did not undergo oophorectomy formed the control group (Gr...
Antioxidantes/análisis,
Antioxidantes/metabolismo,
Catarata/etiologÃa,
Catarata/metabolismo,
Diabetes Mellitus Experimental/metabolismo,
Glucocorticoides/farmacologÃa,
Cristalino/metabolismo,
Menopausia/metabolismo,
Metilprednisolona/farmacologÃa,
Modelos Animales,
OvariectomÃa,
Oxidantes/metabolismo,
Estrés Oxidativo/fisiologÃa,
Ratas Wistar,
Valores de Referencia,
EspectrofotometrÃa
Abstract Background: Thyroid hormone deficiency during fetal life could affect the cardiac function in later life. The mechanism underlying this action in fetal hypothyroidism (FH) in rats has not been elucidated thus far. Objective: The aim of this study is to evaluation the effect of FH on cardiac ...
Antitiroideos,
Peso Corporal/efectos de los fármacos,
Hipotiroidismo Congénito/sangre,
Hipotiroidismo Congénito/inducido quÃmicamente,
Hipotiroidismo Congénito/metabolismo,
ADN Complementario/metabolismo,
Modelos Animales de Enfermedad,
Frecuencia CardÃaca,
Miocardio/metabolismo,
Cadenas Pesadas de Miosina/metabolismo,
Propiltiouracilo,
ARN Mensajero/metabolismo,
Distribución Aleatoria,
Ratas Wistar,
Tiroxina/sangre,
Triyodotironina/sangre,
Presión Ventricular
RESUMO O bimatoprost é utilizado comumente como a droga de primeira escolha no tratamento do glaucoma primário de ângulo aberto. Hiperemia conjuntival, crescimento dos cÃlios, enoftalmia, escurecimento cutâneo periocular, sulco palpebral profundo e prurido ocular têm sido relatados em pacientes que...
With aging the kidney exhibits progressive deterioration, with a decrease in renal function. Most of the filtered Na+ is actively reabsorbed in the proximal tubules through different transporters located in apical membrane. This process is possible because basolateral Na+/K+-ATP-ase generates electrochem...
Envejecimiento/metabolismo,
Secuencia de Bases,
Corteza Renal/enzimologÃa,
Médula Renal/enzimologÃa,
ARN Mensajero/análisis,
ARN Mensajero/metabolismo,
Distribución Aleatoria,
Ratas Wistar,
Sodio/metabolismo,
ATPasa Intercambiadora de Sodio-Potasio/análisis,
ATPasa Intercambiadora de Sodio-Potasio/genética,
ATPasa Intercambiadora de Sodio-Potasio/metabolismo
ABSTRACT Objective: to evaluate the influence of Duodenal reflux in histological changes of the gastric mucosa of rats infected with Helicobacter pylori submitted to pyloroplasty. Methods: after two weeks of acclimation, we infected 30 male Wistar rats with Helicobacter pylori. We randomly divided th...
Pacagnelli, Francis Lopes;
Sabela, Ana Karênina Dias de Almeida;
Mariano, Thaoan Bruno;
Ozaki, Guilherme Akio Tamura;
Castoldi, Robson Chacon;
Carmo, Edna Maria do;
Carvalho, Robson Francisco;
Tomasi, Loreta Casquel;
Okoshi, Katashi;
Vanderlei, Luiz Carlos Marques.
Abstract Background: Right-sided heart failure has high morbidity and mortality, and may be caused by pulmonary arterial hypertension. Fractal dimension is a differentiated and innovative method used in histological evaluations that allows the characterization of irregular and complex structures and the...
Modelos Animales de Enfermedad,
EcocardiografÃa,
Fractales,
Insuficiencia CardÃaca/etiologÃa,
Insuficiencia CardÃaca/patologÃa,
Insuficiencia CardÃaca/fisiopatologÃa,
Hipertensión Pulmonar/complicaciones,
Hipertensión Pulmonar/patologÃa,
Hipertensión Pulmonar/fisiopatologÃa,
Monocrotalina,
Miocitos CardÃacos/patologÃa,
Ratas Wistar,
Valores de Referencia,
Reproducibilidad de los Resultados,
Volumen Sistólico/fisiologÃa,
Disfunción Ventricular Izquierda/patologÃa,
Disfunción Ventricular Izquierda/fisiopatologÃa,
Disfunción Ventricular Derecha/patologÃa,
Disfunción Ventricular Derecha/fisiopatologÃa
ABSTRACT PURPOSE: To evaluate the effects of levobupivacaine on neuromuscular transmission and neuromuscular blockade produced by pancuronium in vitro. METHODS: Thirty rats were distributed into groups (n = 5) according to the drug used alone or in combination: Group I - levobupivacaine (5 µg.mL-1); ...
BupivacaÃna/análogos & derivados,
Bloqueo Neuromuscular,
Unión Neuromuscular/efectos de los fármacos,
Pancuronio/farmacologÃa,
Transmisión Sináptica/efectos de los fármacos,
Anestésicos Locales/farmacologÃa,
BupivacaÃna/farmacologÃa,
Diafragma/efectos de los fármacos,
Diafragma/inervación,
Quimioterapia Combinada,
Estimulación Eléctrica/métodos,
Potenciales de la Membrana/efectos de los fármacos,
Potenciales de la Membrana/fisiologÃa,
Modelos Animales,
Unión Neuromuscular/fisiologÃa,
Fármacos Neuromusculares no Despolarizantes/farmacologÃa,
Ratas Wistar,
Transmisión Sináptica/fisiologÃa
ABSTRACT PURPOSE: To evaluate the effects of low intensity ultrasound on the healing process of third degree burn wounds in experimentally induced diabetic Wistar rats. METHODS: One hundred rats were divided into: control group; non-diabetic treated group; diabetic control group; diabetic treated group...
Inductores de la Angiogénesis/uso terapéutico,
Quemaduras/terapia,
Diabetes Mellitus Experimental,
Piel/lesiones,
Terapia por Ultrasonido/métodos,
Cicatrización de Heridas/fisiologÃa,
Quemaduras/patologÃa,
Colágeno/análisis,
Diabetes Mellitus Experimental/complicaciones,
Diabetes Mellitus Experimental/terapia,
Fibroblastos/patologÃa,
Tejido de Granulación,
Modelos Animales,
Necrosis/patologÃa,
Necrosis/rehabilitación,
Ratas Wistar
ABSTRACT PURPOSE: To investigate changes in the serum concentration and renal expression of IL-1 and TNF-α cytokines in rats that received sevoflurane and glibenclamide prior to hemorrhage. METHODS: Two groups of sevoflurane-anesthetized Wistar rats (n=10): G1 (control) and G2 (glibenclamide, 1 Â...
Gliburida/farmacologÃa,
Hipoglucemiantes/farmacologÃa,
Interleucina-1/metabolismo,
Riñón/efectos de los fármacos,
Choque Hemorrágico/metabolismo,
Factor de Necrosis Tumoral alfa/metabolismo,
Anestésicos por Inhalación/administración & dosificación,
Peso Corporal/efectos de los fármacos,
Canales KATP/antagonistas & inhibidores,
Riñón/irrigación sanguÃnea,
Riñón/metabolismo,
Túbulos Renales/efectos de los fármacos,
Túbulos Renales/metabolismo,
Éteres MetÃlicos/administración & dosificación,
Modelos Animales,
Distribución Aleatoria,
Ratas Wistar
