ABSTRACT Autoimmune encephalitis (AIE) is one of the most common causes of noninfectious encephalitis. It can be triggered by tumors, infections, or it may be cryptogenic. The neurological manifestations can be either acute or subacute and usually develop within six weeks. There are a variety of clinical...
Encefalitis Antirreceptor N-Metil-D-Aspartato/complicaciones,
Diagnóstico Diferencial,
Encefalitis/diagnóstico,
Encefalitis/etiología,
Encefalitis/fisiopatología,
Encefalitis/terapia,
Enfermedad de Hashimoto/diagnóstico,
Enfermedad de Hashimoto/etiología,
Enfermedad de Hashimoto/fisiopatología,
Enfermedad de Hashimoto/terapia,
Inmunoterapia
Noncolorectal gastrointestinal (GI) malignancies are among the most frequently diagnosed cancers. Despite the undeniable progress in systemic treatments in recent decades, further improvements using cytotoxic chemotherapy seem unlikely. In this setting, recent discoveries regarding the mechanism underlyi...
Technological developments have allowed improvements in radiotherapy delivery, with higher precision and better sparing of normal tissue. For many years, it has been well known that ionizing radiation has not only local action but also systemic effects by triggering many molecular signaling pathways. The...
Apoptosis/inmunología,
Apoptosis/efectos de la radiación,
Muerte Celular/efectos de la radiación,
Relación Dosis-Respuesta en la Radiación,
Sistema Inmunológico/efectos de la radiación,
Inmunoterapia/métodos,
Inmunoterapia/tendencias,
Necrosis/etiología,
Neoplasias/inmunología,
Neoplasias/radioterapia,
Radiación Ionizante,
Radioterapia/efectos adversos,
Radioterapia/tendencias
ABSTRACT Objective: To investigate the correlation between total lymphocyte and CD3+ T cell counts in peripheral blood in renal transplant patients treated with anti-thymocyte globulin, and discuss related outcomes. Methods: A single-center, retrospective study involving 226 patients submitted to kidne...
Anticuerpos Monoclonales/uso terapéutico,
Complejo CD3,
Citometría de Flujo/métodos,
Rechazo de Injerto/terapia,
Inmunoterapia/métodos,
Isoanticuerpos/uso terapéutico,
Trasplante de Riñón,
Recuento de Linfocitos,
Persona de Mediana Edad,
Monitorización Inmunológica/instrumentación,
Estudios Retrospectivos,
Análisis de Supervivencia,
Linfocitos T/inmunología,
Timocitos/inmunología,
Receptores de Trasplantes
The immunologic landscape of tumors has been continuously unveiled, providing a new look at the interactions between cancer cells and the immune system. Emerging tumor cells are constantly eliminated by the immune system, but some cells establish a long-term equilibrium phase leading to tumor immunoediti...
Antígenos de Neoplasias/análisis,
Vacunas contra el Cáncer/uso terapéutico,
Transformación Celular Neoplásica,
Terapia Combinada,
Terapia Genética,
Inmunoterapia/métodos,
Mutación,
Neoplasias/genética,
Neoplasias/inmunología,
Neoplasias/terapia,
Escape del Tumor/inmunología,
Microambiente Tumoral/inmunología
While cancer immunotherapy has gained much deserved attention in recent years, many areas regarding the optimization of such modalities remain unexplored, including the development of novel approaches and the strategic combination of therapies that target multiple aspects of the cancer-immunity cycle. Ou...
ABSTRACT Immunotherapy-induced pneumonitis is a rare complication with incidence estimated around 3%. This disease is difficult to diagnose and has great morbidity. For this reason, it became a challenge for oncologists and emergencists. We reviewed the case of five patients who used anti-PD1 (program ce...
Corticoesteroides/uso terapéutico,
Anticuerpos Monoclonales/efectos adversos,
Anticuerpos Monoclonales/uso terapéutico,
Anticuerpos Monoclonales Humanizados/efectos adversos,
Anticuerpos Monoclonales Humanizados/uso terapéutico,
Antineoplásicos/efectos adversos,
Antineoplásicos/uso terapéutico,
Carcinoma/terapia,
Resultado Fatal,
Inmunoterapia/efectos adversos,
Neoplasias Pulmonares/terapia,
Persona de Mediana Edad,
Nivolumab,
Neumonía/inducido químicamente,
Neumonía/diagnóstico por imagen,
Neumonía/tratamiento farmacológico
Atualmente, muitas das vacinas em desenvolvimento são aquelas compostas de proteínas antigênicas individuais de parasitas ou uma combinação de vários antígenos individuais que são produzidos como produtos recombinantes obtidos por técnicas de biologia molecular. Dentre elas a Leish-1...
Hepner, Adriana;
Salgues, Alessandra;
Anjos, Carlos A. dos;
Sahade, Marina;
Camargo, Veridiana P;
Garicochea, Bernardo;
Shoushtari, Alexander N;
Postow, Michael A;
Fernandes, Gustavo S;
Munhoz, Rodrigo R.
Summary Following decades of relative ostracism, advances in the treatment of melanoma have brought a new reality for patients, physicians and researchers. While antibodies targeting molecules involved in the modulation of the interaction between melanoma and immune cells changed the meaning of the term ...
Abstract: The stimulation of the immune system, in order to generate an attack against cancer cells, similarly to that which occurs in infectious disease, has long been matter of interest in oncology; however, only limited success has been achieved, with different treatment strategies tested in recent ye...
Anticuerpos Monoclonales/uso terapéutico,
Anticuerpos Monoclonales Humanizados/uso terapéutico,
Antineoplásicos Inmunológicos/uso terapéutico,
Protocolos de Quimioterapia Combinada Antineoplásica,
Antígeno CTLA-4/antagonistas & inhibidores,
Inmunoterapia/métodos,
Ipilimumab/uso terapéutico,
Melanoma/tratamiento farmacológico,
Melanoma/inmunología,
Neoplasias/tratamiento farmacológico,
Neoplasias/inmunología,
Nivolumab,
Receptor de Muerte Celular Programada 1/antagonistas & inhibidores,
Resultado del Tratamiento
