Results: 1561

Cambios en la actividad de algunas enzimas séricas en ratas con hipervitaminosis E
Changes in activity of some serum enzymes in rats with hypervitaminosis E

Rev. Inst. Nac. Hig; 45 (1), 2014
Poco se sabe sobre los cambios en la actividad de las enzimas séricas relacionadas con la función hepática durante la hipervitaminosis E. En el presente trabajo se estudió el efecto de la administración intraperitoneal de 50, 100, 200 y 400 mg de vitamina E/día, durante 20 días sobre la actividad ...

A single high dose of chlorpyrifos reduces long-term basal c-fos expression in the rat arcuate hypothalamic nucleus

Int. j. morphol; 32 (1), 2014
Chlorpyrifos (CPF) is an organophosphate compound used worldwide as a pesticide in agriculture that, after subcutaneous injection, keeps acetylcholinesterase (AChE) activity inhibited within an organism for months. Ample clinical and experimental evidence shows that CPF exposure induces relevant and pers...

Ação do ultrassom terapêutico e laser de baixa intensidade na regeneração nervosa em Rattus norvegicus

Envolvimento da metilecgonidina, produto de pirólise da cocaína, na farmacodependência

O crack é a forma fumada de administração da cocaína com o maior potencial para causar dependência. Até 80% da sua fumaça consiste no produto de pirólise da cocaína, a metilecgonidina (AEME). Apesar do vasto conhecimento acerca dos efeitos e prejuízos causados pela cocaína, nenhum trabalho ava...

Passiflora incarnata treatment during gestation and lactation: toxicological and antioxidant evaluation in wistar dams

Braz. j. pharm. sci; 50 (2), 2014
Passiflora incarnata is marketed in many countries as a phytomedicine. Even though the directions of most marketed phytomedicines recommend them to be used under medical supervision, reproductive and developmental studies are sparse and not mandatory for regulatory purposes. In this study, a reproductive...

Protective effect of guabiju (Myrcianthes pungens (O. Berg) D. Legrand) and red guava (Psidium cattleyanum Sabine) against cisplatin-induced hypercholesterolemia in rats

Braz. j. pharm. sci; 50 (3), 2014
The present study was the first to examine the protective effect and antioxidant potential of two fruits native to the south of Brazil, namely guabiju (Myrcianthes pungens (O. Berg) D. Legrand) and red guava (Psidium cattleyanum Sabine), with respect to reducing the effects of cisplatin-induced hyperchol...

Protective effect of bixin on carbon tetrachloride-induced hepatotoxicity in rats

Biol. Res; 47 (), 2014
BACKGROUND: The liver is an important organ for its ability to transform xenobiotics, making the liver tissue a prime target for toxic substances. The carotenoid bixin present in annatto is an antioxidant that can protect cells and tissues against the deleterious effects of free radicals. In this study, ...

Assessment of pharmacological activities of two medicinal plant of Bangladesh: Launaea sarmentosa and Aegialitis rotundifolia roxb in the management of pain, pyrexia and inflammation

Biol. Res; 47 (), 2014
BACKGROUND: The current study aims at evaluating the analgesic, anti-pyretic and anti-inflammatory properties of methanolic extract of the stem, bark and leaves of Launaea sarmentosa and Aegialitis rotundifolia roxb. RESULTS: The AELS and AEAR extract presented a significant (***p < 0.001) dose dependent...

Activation of group II metabotropic glutamate receptors blocks zinc release from hippocampal mossy fibers

Biol. Res; 47 (), 2014
BACKGROUND: The hippocampal CA3 area contains large amounts of vesicular zinc in the mossy fiber terminals which is released during synaptic activity, depending on presynaptic calcium. Another characteristic of these synapses is the presynaptic localization of high concentrations of group II metabotropic...

Efecto toxicológico del jincho jincho (Heracium neoherrerae), altamisa (Ambrosia arborescens), diente de león (Taraxacum officinale), huira huira (Pseudogmaphalium spicatum) y mishico (Bidens andicola) en ratas (Wistar)
Toxicological effect of jincho jincho (Heracium neoherrerae), altamisa (Ambrosia arborescens), dandelion (Taraxacum officinale), huira huira (Pseudogmaphalium spicatum) and mishico (Bidens andicola) on rats (Wistar)

La investigación del efecto toxicológico de “mishico” (Bidens andicola), “diente de león” (Taraxacum officinale), “huira huira” (Pseduogmaphalium spicatum), “jincho jincho” (Hieracium neoherrerae) y “altamisa” (Ambrosia arborescens) de la familia Asterácea en ratas wistar, se real...