Results: 146

Integrin-β1, not integrin-β5, mediates osteoblastic differentiation and ECM formation promoted by mechanical tensile strain

Biol. Res; 48 (), 2015
BACKGROUND: Mechanical strain plays a great role in growth and differentiation of osteoblast. A previous study indicated that integrin-β (β1, β5) mediated osteoblast proliferation promoted by mechanical tensile strain. However, the involvement of integrin-β; in osteoblastic differentiation and extrac...

Amniotic fluid exerts a neurotrophic influence on fetal neurodevelopment via the ERK/GSK-3 pathway

Biol. Res; 48 (), 2015
BACKGROUND: The fetus is surrounded by the amniotic fluid (AF) contained by the amniotic sac of the pregnant female. The AF is directly conveyed to the fetus during pregnancy. Although AF has recently been reported as an untapped resource containing various substances, it remains unclear whether the AF c...

Suppression of miR-181 a attenuates H2O2-induced death of mesenchymal stem cells by maintaining hexokinase II expression

Biol. Res; 48 (), 2015
BACKGROUND: Low survival rate of transplanted cells compromises the efficacy of cell therapy. Hexokinase II (HKII) is known to have anti-apoptotic activity through its interaction with mitochondria. The objective was to identify miRNAs targeting HKII and investigate whether miRNA-mediated modulation of H...

Flavonoids isolated from Tridax procumbens (TPF) inhibit osteoclasts differentiation and bone resorption

Biol. Res; 48 (), 2015
BACKGROUND: The Tridax procumbens flavonoids (TPF), are well known for their medicinal properties among local natives. The TPF are traditionally used for dropsy, anaemia, arthritis, gout, asthma, ulcer, piles, and urinary problems. It also used in treating gastric problems, body pain, and rheumatic pains...

Functional disruption of human leukocyte antigen II in human embryonic stem cell

Biol. Res; 48 (), 2015
BACKGROUND: Theoretically human embryonic stem cells (hESCs) have the capacity to self-renew and differentiate into all human cell types. Therefore, the greatest promise of hESCs-based therapy is to replace the damaged tissues of patients suffering from traumatic or degenerative diseases by the exact sam...

Using mesenchymal stem cells as a therapy for bone regeneration and repairing

Biol. Res; 48 (), 2015
Bone is a unique tissue which could regenerate completely after injury rather than heal itself with a scar. Compared with other tissues the difference is that, during bone repairing and regeneration, after the inflammatory phase the mesenchymal stem cells (MSCs) are recruited to the injury site and diffe...

Tridax procumbens flavonoids promote osteoblast differentiation and bone formation

Biol. Res; 48 (), 2015
BACKGROUND: Tridaxprocumbens flavonoids (TPFs) are well known for their medicinal properties among local natives. Besides traditionally used for dropsy, anemia, arthritis, gout, asthma, ulcer, piles, and urinary problems, it is also used in treating gastric problems, body pain, and rheumatic pains of joi...

Cloning, characterization and expression of Peking duck fatty acid synthase during adipocyte differentiation

Electron. j. biotechnol; 17 (6), 2014
Background Fatty acid synthase (FAS) is a key enzyme of de novo lipogenesis (DNL), which has been cloned from several species: Gallus gallus, Mus musculus, Homo sapiens, but not from Anas platyrhynchos. The current study was conducted to obtain the full-length coding sequence of Peking duck FAS and inves...

Construction of a eukaryotic expression vector for pEGFP-FST and its biological activity in duck myoblasts

Electron. j. biotechnol; 17 (5), 2014
Background Follistatin (FST), a secreted glycoprotein, is intrinsically linked to muscle hypertrophy. To explore the function of duck FST in myoblast proliferation and differentiation, the pEGFP-FST eukaryotic expression vector was constructed and identified. The biological activities of this vector were...

Biocompatibilidad de células madres mesenquimales de tejido gingival humano en cultivoconun andamiaje de polímero sintético de ácido poliláctico (OPLA)

Int. j. morphol; 32 (3), 2014
La ingeniería tisular se plantea como tratamiento ideal para la regeneración de tejidos con la utilización de andamiajes, células madres y factores de crecimiento. Las células madres de origen gingival plantean ventajas de obtención, mientras que el OPLA 3D permite cultivos de alta densidad celular...