A doença de Chagas afeta mais de 8 milhões de pessoas nos países em desenvolvimento, e dispõe de uma terapia ultrapassada e altamente tóxica. Considerando o Brasil uma das maiores biodiversidades do mundo, compostos de sua flora podem contribuir como novos protótipos farmacêuticos. Neolignanas, is...
The present study aimed to develop a fermented soy beverage containing fruit by-products and probiotics and to evaluate the impact of this product on the composition and metabolic activity of the human intestinal microbiota using an in vitro simulation model of the intestinal conditions (TIM-2). Therefor...
Os sistemas de sinalização de dois componentes são sistemas prevalentes em bactérias, permitindo a adaptação a diferentes condições ambientais. O sistema de dois componentes classicamente possui uma proteína histidina quinase, o primeiro componente, capaz de reconhecer o estímulo ambiental e fo...
Diniz-Sousa, Rafaela;
Kayano, Anderson M;
Caldeira, Cleópatra A;
Simões-Silva, Rodrigo;
Monteiro, Marta C;
Moreira-Dill, Leandro S;
Grabner, Fernando P;
Calderon, Leonardo A;
Zuliani, Juliana P;
Stábeli, Rodrigo G;
Soares, Andreimar M.
Wasp venoms constitute a molecular reservoir of new pharmacological substances such as peptides and proteins, biological property holders, many of which are yet to be identified. Exploring these sources may lead to the discovery of molecules hitherto unknown. This study describes, for the first time in h...
Differentiation between inflammatory bowel disease (IBD) and irritable bowel syndrome (IBS) can
be complex as their symptoms are often similar and unspecific. Fecal biomarkers could be useful
to select patients with suspected organic diseases for colonoscopy, with the aim to improve early
diagnosis and t...
En este trabajo de desarrollo experimental, la Escuela de Ingeniería Química de ITCA-FEPADE se propuso comprobar la efectividad de las cáscaras y pseudotallo de guineo y el endocarpo de coco, previamente tratados, para remover la contaminación por metales pesados en una muestra de agua. Para tal obje...
Marasmius androsaceus is a medicinal fungus mainly used to treat various forms of pain in China. This study investigated the analgesic effects of an ethanol extract of M. androsaceus (MAE) and its potential molecular mechanisms. Oral administration of MAE (50, 200, and 1000 mg/kg) had significant analges...
Dermatophagoides farinae (Der f), one of the main species of house dust mites, produces more than 30 allergens. A recently identified allergen belonging to the alpha-tubulin protein family, Der f 33, has not been characterized in detail. In this study, we used bioinformatics tools to construct the second...
Alérgenos/química,
Alérgenos/genética,
Alérgenos/inmunología,
Antígenos Dermatofagoides/química,
Antígenos Dermatofagoides/genética,
Antígenos Dermatofagoides/inmunología,
Biología Computacional,
Dermatophagoides farinae/química,
Dermatophagoides farinae/genética,
Dermatophagoides farinae/inmunología,
Mapeo Epitopo,
Epítopos de Linfocito B/química,
Epítopos de Linfocito B/genética,
Epítopos de Linfocito T/química,
Epítopos de Linfocito T/genética,
Estructura Molecular,
Estructura Terciaria de Proteína,
Análisis de Secuencia de Proteína,
Tubulina (Proteína)/química,
Tubulina (Proteína)/genética,
Tubulina (Proteína)/inmunología
The prevalence of cardiovascular and metabolic diseases is increased in postmenopausal women, which contributes to the burden of illnesses in this period of life. Yerba mate (Ilex paraguariensis) is a native bush from Southern South America. Its leaves are rich in phenolic components, which may have anti...
