Cui, Xiaorui;
Li, Lan;
Yu, Lei;
Xing, Huijuan;
Chang, Hong;
Zhao, Li;
Qian, Jin;
Song, Qingwei;
Zhou, Shiyu;
Dong, Chunbo.
OBJECTIVES: Parkinson's disease (PD) and the parkinsonian variant of multiple system atrophy (MSA-P) are distinct neurodegenerative disorders that share similar clinical features of parkinsonism. The morphological alterations of these diseases have yet to be understood. The purpose of this study was to e...
Parkinson's disease cannot be cured but symptoms can be improved by making use of physical therapy. The objective of the study was to compare the effect of routine exercises and Tai Chi on physical and clinical performance in elderly people suffering from Parkinson's disease. Data from interviews, physic...
Resumo Introdução A Doença de Parkinson (DP) resulta em condições clínicas desfavoráveis para a saúde bucal e não existe estudo publicado sobre dor ao tratamento odontológico em pacientes com DP. Objetivo Pesquisar associação entre características clínicas da DP e a intensidade de dor em ...
Dolor Asociado a Procedimientos Médicos,
Asociación,
Disfunción Cognitiva,
Enfermedad de Parkinson/epidemiología,
Salud Bucal,
Sensación,
Pruebas de Estado Mental y Demencia,
Depresión,
Percepción del Dolor,
Enfermedad de Parkinson,
Atención Odontológica
Resumo Este estudo objetiva conhecer os padrões de resposta de transição dos cuidadores familiares e a influência destes na realização de cuidados ao idoso com doença de Parkinson. Para isso, trata-se de um estudo exploratório, descritivo e qualitativo, realizado com 20 familiares cuidadores de i...
Introduction: Deep brain stimulation (DBS) is a standard surgical procedure for the treatment of advanced Parkinson Disease (PD) with motor complications that cannot be adequately managed by medical treatment. Currently available literature can guide physicians on basic aspects of...
Abstract Introduction: The multidimensional fatigue inventory (MFI) has not been applied in Brazilian Parkinson`s disease (PD) population due to the lack of validation. Objective: The aim of this study was to cross-culturally adapt, to validate, and investigate the psychometric properties of Brazilian...
Neurodegeneration is a progressive loss of neurons both structurally and functionally causing neuronal cell death ultimately leading to development of various neurodegenerative diseases. Due to poor pharmacokinetic profile of neurotrophins, there still remains a challenge in their...
BACKGROUND: Long non-coding RNA small molecule RNA host gene 1 (SNHG1) was previously identified to be relevant with Parkinson's disease (PD) pathogenesis. This work aims to further elucidate the regulatory networks of SNHG1 involved in PD. Methods: 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-hydrochlo...
1-Metil-4-fenilpiridinio/toxicidad,
Fosfohidrolasa PTEN/metabolismo,
Enfermedad de Parkinson/metabolismo,
Proteínas Proto-Oncogénicas c-akt/metabolismo,
ARN Largo no Codificante/metabolismo,
Serina-Treonina Quinasas TOR/metabolismo,
Enfermedad de Parkinson/genética,
ARN Largo no Codificante/genética,
Apoptosis,
Western Blotting,
Células Cultivadas,
Modelos Animales de Enfermedad,
Regulación de la Expresión Génica,
Ratones Endogámicos C57BL,
MicroARNs,
Reacción en Cadena en Tiempo Real de la Polimerasa,
Transducción de Señal,
Transfección
Evidence from previous voxel-based morphometry (VBM) studies indicates that widespread brain regions are involved in Parkinson's disease with mild cognitive impairment (PD-MCI). However, the spatial localization reported for gray matter (GM) abnormalities is heterogeneous. The aim of the present study wa...
