Results: 471

Evidencia actual sobre los beneficios de la dieta mediterránea en salud

Rev. méd. Chile; 144 (8), 2016
The Mediterranean diet is currently considered a functional diet with an increasing amount of scientific evidence that supports its beneficial effects in human health. Several observational cross-sectional and prospective cohort studies show an association between this diet and a lower prevalence and inc...

Network Meta-analysis to Synthesize Evidence for Decision Making in Cardiovascular Research

Arq. bras. cardiol; 106 (4), 2016
Abstract Clinical decision-making requires synthesis of evidence from literature reviews focused on a specific theme. Evidence synthesis is performed with qualitative assessments and systematic reviews of randomized clinical trials, typically covering statistical pooling with pairwise meta-analyses. Thes...

HPV vaccination impact on a cervical cancer screening program: methods of the FASTER-Tlalpan Study in Mexico

Salud pública Méx; 58 (2), 2016
Abstract Objective: To outline the design of a clinical trial to evaluate the impact of HPV vaccination as part of a hrHPV-based primary screening program to extend screening intervals. Materials and methods: A total of 18,000 women aged 25-45 years, attending the regular cervical cancer-screening prog...

Sponsored multicentric clinical research conducted in Brazil in the respiratory area - losses and gains

Summary Objective: To evaluate the sponsored centers for clinical trial in the respiratory care setting in Brazil: profile; logistics and structure. Methods: Principal investigators (29) and subinvestigators (30) of 39 research centers completed the questionnaires that addressed personal identification...

Practical and conceptual issues of clinical trial registration for Brazilian researchers

Säo Paulo med. j; 134 (1), 2016
CONTEXT AND OBJECTIVE: Clinical trial registration is a prerequisite for publication in respected scientific journals. Recent Brazilian regulations also require registration of some clinical trials in the Brazilian Clinical Trials Registry (ReBEC) but there is little information available about practical...

Escenario actual y perspectivas de la terapia con células madre mesenquimales en medicina intensiva

Rev. méd. Chile; 144 (2), 2016
Development of innovative therapies in intensive care medicine is particularly important since diseases as sepsis, acute respiratory distress syndrome (ARDS) and acute renal injury (AKI) have an elevated morbidity and mortality in spite of current gold-standard approaches. Mesenchymal stem cells (MSC) ma...

Sharing clinical trial data: a proposal from the International Committee of Medical Journal Editors

Rev. méd. Chile; 144 (1), 2016
El Comité Internacional de Editores de Revistas Médicas (ICMJE) considera que es una obligación ética compartir responsablemente los datos generados por ensayos clínicos, porque los participantes se han sometido a un riesgo particular. En un consenso creciente, muchos patrocinadores en el mundo -Fun...

La cara oculta del estudio 329 y la manipulación de la evidencia científica
Study’s 329 hiddens face and scientifics evidence manipulation

El emblemático ensayo clínico 329, financiado por Smith Kline Beecham (actualmente GlaxoSmith-Kline) y publicado en2001, permitió posicionar a la paroxetina como un tratamiento efectivo y seguro para la depresión mayor en adolescentes. En la presente editorial el autor describe los sucesos ocurridos ...