Results: 354

Estudo conformacional e modulação da proteína NF-κB na via de sinalização de processos inflamatórios produzidos pelo complexo Mycobacterium tuberculosis (MTC)

A tuberculose é uma das doenças infecciosas que mais mata em todo o mundo e é causada por micobactérias do complexo Mycobacterium tuberculosis (MTC). A infecção desencadeia um processo inflamatório que leva à ativação de diversas vias celulares dependentes do fator nuclear kappa B (NF-κB), sen...

Accuracy of a rapid molecular test for tuberculosis in sputum samples, bronchoalveolar lavage fluid, and tracheal aspirate obtained from patients with suspected pulmonary tuberculosis at a tertiary referral hospital

J. bras. pneumol; 45 (2), 2019
ABSTRACT Tuberculosis continues to be a major public health problem worldwide. The aim of the present study was to evaluate the accuracy of the Xpert MTB/RIF rapid molecular test for tuberculosis, using pulmonary samples obtained from patients treated at the Júlia Kubitschek Hospital, which is operated ...

Mycobacterium tuberculosis spoligotypes and drug-resistant characterization from Beira compared to genotypes circulating in Mozambique

Abstract INTRODUCTION Mozambique is one of three countries with high prevalence of tuberculosis (TB), TB/human immunodeficiency virus coinfection, and multidrug-resistant TB. We aimed to describe Mycobacterium tuberculosis spoligotypes circulating among drug resistant (DR) strains from Beira, Mozambiqu...

Serum pyrazinamide concentrations in patients with pulmonary tuberculosis

J. bras. pneumol; 45 (2), 2019

Speeding up the diagnosis of multidrug-resistant tuberculosis in a high-burden region with the use of a commercial line probe assay

J. bras. pneumol; 45 (2), 2019
ABSTRACT Objective: To evaluate the rapid diagnosis of multidrug-resistant tuberculosis, by using a commercial line probe assay for rifampicin and isoniazid detection (LPA-plus), in the routine workflow of a tuberculosis reference laboratory. Methods: The LPA-plus was prospectively evaluated on 341 iso...

Primary bacillary resistance in multidrug-resistant tuberculosis and predictive factors associated with cure at a referral center in São Paulo, Brazil

J. bras. pneumol; 45 (2), 2019
ABSTRACT Objective: To identify transmitted or primary resistance among cases of multidrug-resistant tuberculosis and predictive factors for cure in multidrug-resistant tuberculosis after the first treatment. Method: Descriptive study of a cohort from 2006 to 2010, in a reference unit of tuberculosis i...

Comparison of GeneXpert MTB/RIF assay and LED-FM microscopy for the diagnosis of extra pulmonary tuberculosis in Khyber Pakhtunkhwa, Pakistan

Braz. j. microbiol; 49 (4), 2018
ABSTRACT GeneXpert is one of the recent technological instruments used to diagnose tuberculosis in a short span of time. In this study, the performance of GeneXpert MTB/RIF assay for the diagnosis of extrapulmonary tuberculosis (EPTB) was compared with light-emitting diode Fluorescent Microscopy (LED-FM)...

Relato da ocorrência simultânea de escrofuloderma, eritema indurado de Bazin e tuberculide pápulo-necrótica em paciente imunocompetente

Modelo do estudo: relato de caso Importância do problema: A tuberculose é um grave problema de saúde no nosso país, no entanto poucos profissionais sabem identificar as formas extrapulmonares da doença, que são responsáveis por 23,3% dos óbitos por tuberculose no Brasil. Das formas extra-pulmonar...

Perfil clínico-epidemiológico da tuberculose intestinal em pacientes de um hospital universitário

OBJETIVO: Estabelecer o perfil clínico-epidemiológico da tuberculose intestinal em pacientes assistidos em um ambulatório específico. MÉTODOS: Estudo descritivo e retrospectivo, no qual foram avaliadas as principais características da população com diagnóstico de tuberculose intestinal atendida ...