Results: 172

The use of biomarkers in clinical osteoporosis

Summary Osteoporosis is a disease of ascending character in the world population; in this context, bone biomarkers are being increasingly studied in order to aid in the diagnosis and monitoring of these patients. The main objective of this study was a literature review of articles whose main theme was th...

Biomarcadores de risco cardiovascular em pacientes HIV positivos tratados e não tratados com terapia antirretroviral

No advento dos antirretrovirais potentes, os indivíduos infectados pelo vírus da imunodeficiência humana (HIV) começaram a apresentar risco maior para o desenvolvimento de doença cardiovascular (DCV). Este aumento do risco cardiovascular pode ser associado tanto à infecção viral quanto ao tratame...

Biomarker exposure of phenolic compounds from grumixama (Eugenia brasiliensis Lam. ) in healthy human model: Metabolomic approach

The fruits and vegetables intake has been associated to the reduction of chronic non-communicable disease incidence, such as cancer, metabolic syndrome and cardiovascular diseases. The biological activities attribute to them has been related mainly to the phenolic compounds, such as flavonoids and ellagi...

Gender differences in biochemical markers and oxidative stress of rats after 28 days oral exposure to a mixture used for weight loss containing p-synephrine, ephedrine, salicin, and caffeine

Braz. j. pharm. sci; 52 (1), 2016
ABSTRACT The association of p-synephrine, ephedrine, salicin, and caffeine in dietary supplements and weight loss products is very common worldwide, even though ephedrine has been prohibited in many countries. The aim of this study was to evaluate a 28-day oral exposure toxicity profile of p-synephrine, ...

A study on β-defensin-2 and histatin-5 as a diagnostic marker of early childhood caries progression

Biol. Res; 48 (), 2015
BACKGROUND: Recently, a continuous growth of interest has been observed in antimicrobial peptides (AMPs) in the light of an alarming increase in resistance of bacteria and fungi against antibiotics. AMPs are used as biomarkers in diagnosis and monitoring of oral cavity pathologies. Therefore, the determi...

Effects of biodegradable detergents in the accumulation of lipofuscin (age pigment) in gill and liver of two neotropical fish species

Int. j. morphol; 32 (3), 2014
Currently there is a growing concern, in both population and governments, to identify the effects of substances commonly disposed of into rivers and lakes, on aquatic fauna and flora. Thus the objective of the present study was to verify effects of biodegradable detergents and water from an urban lake on...

Novos biomarcadores inflamatórios e de disfunção endotelial: predição de risco cardiovascular

Rev. AMRIGS; 58 (1), 2014
Em consequência do avanço das pesquisas no campo da biologia molecular e celular, ampliou-se o entendimento dos mecanismos fisiopatológicos das doenças cardiovasculares (DCV) e, como consequência, uma nova série de biomarcadores tem emergido como promissoras ferramentas para refinar o diagnóstico,...

Investigação de potenciais biomarcadores redox - um enfoque em aldeídos e seus produtos

As espécies reativas são associadas a processos toxicológicos e fisiopatológicos, agindo como importantes mediadores, por exemplo, na sinalização celular. Diversas classes de compostos têm sido utilizadas como possíveis biomarcadores de estresse redox, destacando-se os aldeídos α,β-insaturados...

Estudo de variações genômicas para a identificação de biomarcadores personalizados e novos alvos terapêuticos em tumores colorretais

O câncer colorretal é um dos tipos de tumores mais frequentes no mundo. A atual dificuldade na avaliação correta da resposta ao tratamento torna necessário o desenvolvimento de novas abordagens de detecção tumoral. Atualmente, o sequenciamento genômico em larga escala permite um estudo mais compr...