LILACS – Literatura Latinoamericana y del Caribe de Ciencias de la Salud | LILACS

Results: 467

Refletindo o autogerenciamento no seguimento pós terapia antineoplásica: bases para inovação do gerenciamento do cuidado de enfermagem

Introdução: Autogerenciamento é um conceito atual que integra políticas públicas internacionais cujos modelos de atenção à saúde visam, dentre outros princípios, a potencialização da pessoa para assumir o protagonismo das práticas que favoreçam o bem-estar na vivência de uma situação crÃ...

Compostos carbonílicos α, β-insaturados e hidrazonas sintéticas como antiparasitários

Apesar da grande relevância médica e social, e por serem responsáveis por grande parte das mortes em países subdesenvolvidos e em desenvolvimento as doenças negligenciadas (DN), ainda, não apresentam terapêutica eficaz. Dentre as diversas DN, doenças como a doença de Chagas, a Leishmaniose visce...

Componentes químicos del aceite esencial de Ocotea paranaensis (Lauraceae) y sus propiedades antioxidantes, anticancer y antimicrobianas
Chemical constituents of Ocotea paranaensis (Lauraceae) essential oil and their antioxidant, anticancer and antimicrobial properties

La composición química del aceite esencial obtenido de las ramas de Ocotea paranaensis se estudió por cromatografía de gases/espectrometría de masas (CG/MS). Se identificaron veintisiete compuestos, que comprenden el 94,82% de los componentes totales. El aceite se caracterizó por una concentración...

Actividad citotóxica de extractos crudos y fracciones de Blepharocalyx cruckshanksii contra líneas celulares de cáncer humano seleccionadas
Cytotoxic activity of crude extracts and fractions from Blepharocalyx cruckshanksii against selected human cancer cell lines

El presente estudio tiene como objetivo explorar las posibles aplicaciones de los extractos de corteza y hoja de Blepharocalyx cruckshanksii como agente citotóxico contra líneas celulares de cáncer in vitro ((MCF-7, PC-3 y HT-29) mediante el uso de ensayo de sulforhodamine B (SRB). El ensayo de citoto...

Occurrence and Severity of Oral Mucositis in Brazilian Pediatric Cancer Patients

Abstract Objective: To determine the occurrence and severity of oral mucositis (OM) and the factors associated with the onset of severe oral mucositis (SOM) in pediatric cancer patients. Material and Methods: This was a longitudinal and prospective study with 85 children and adolescents (aged 0 to 19 y...

Risk factors associated with antineoplastic chemotherapy-induced nausea and vomiting

ABSTRACT OBJECTIVE: To estimate the incidence and to evaluate risk factors for antineoplastic nausea and vomiting with high and moderate emetogenic chemotherapy in adult patients in the first treatment cycle. METHODS: Prospective cohort study with follow-up of 269 adults during the first cycle of antin...

Apoptosis-related gene expression can predict the response of ovarian cancer cell lines to treatment with recombinant human TRAIL alone or combined with cisplatin

Clinics; 75 (), 2020
OBJECTIVES: The objectives of this study were to determine the sensitivity of ovarian cancer (OC) cell lines (TOV-21G and SKOV-3) to cisplatin and to the recombinant human TRAIL (rhTRAIL), and to evaluate the expression profile of TNFRSF10B, TNFRSF10C, TP53TG5, MDM2, BAX, BCL-2 and CASPASE-8 genes and th...

Anticancer potential of nanogold conjugated toxin GNP-NN-32 from Naja naja venom

Background: Cancer is the second most common fatal disease in the world, behind cardiovascular disorders in the first place. It accounts for around 0.3 million deaths per year in India due to the lack of proper diagnostic facilities, prevention and treatment. Current therapeutic methods do not provide ad...

Amifostine protects from the peripheral sensory neuropathy induced by oxaliplatin in mice

Braz. j. med. biol. res; 53 (11), 2020
Sensory neuropathy is a dose-limiting side effect of oxaliplatin-based cancer treatment. This study investigated the antinociceptive effect of amifostine and its potential neuroprotective mechanisms on the oxaliplatin-related peripheral sensory neuropathy in mice. Oxaliplatin (1 mg/kg) was injected intra...

Cytotoxic and anticancer properties of the Malaysian mangrove pit viper (Trimeresurus purpureomaculatus) venom and its disintegrin (purpureomaculin)

The Asiatic pit vipers from the Trimeresurus complex are medically important venomous snakes. These pit vipers are often associated with snakebite that leads to fatal coagulopathy and tissue necrosis. The cytotoxic venoms of Trimeresurus spp.; however, hold great potential for the development of peptide-...