O diabetes mellitus (DM) é uma doença metabólica complexa. Sua etiologia é
atribuída a uma combinação entre fatores genéticos, ambientais e de estilo de vida.
Contudo, sabe-se que o estresse oxidativo desempenha papel crucial na patogênese
do DM, acarretando em disfunção das células β pancre...
Introdução: A obesidade apresenta uma incidência elevada e gênese multifatorial, como fatores biológicos, ambientais e psicológicos. Dentre os psicológicos, os conflitos na relação mãe-filha podem contribuir para a gênese da obesidade feminina. Objetivo: O objetivo desse estudo é investigar o...
de Melo, TS;
Lima, PR;
Carvalho, KMMB;
Fontenele, TM;
Solon, FRN;
Tomé, AR;
de Lemos, TLG;
da Cruz Fonseca, SG;
Santos, FA;
Rao, VS;
de Queiroz, MGR.
Previous studies have reported on the glucose and lipid-lowering effects of ferulic acid (FA) but its anti-obesity potential has not yet been firmly established. This study investigated the possible anti-obesitogenic effects of FA in mice fed a high-fat diet (HFD) for 15 weeks. To assess the antiobesity ...
Obesity has become a worldwide epidemic and its prevalence has been projected to grow by 40% in the next decade. This increasing prevalence has implications for the risk of diabetes, cardiovascular disease and also for chronic kidney disease (CKD). A high body mass index is one of the strongest risk fact...
Modifications in life-style and/or pharmacotherapies contribute to weight loss and ameliorate the metabolic profile of diet-induced obese humans and rodents. Since these strategies fail to treat hypothalamic obesity, we have assessed the possible mechanisms by which duodenal-jejunal bypass (DJB) surgery ...
Animales Recién Nacidos,
Glucemia/metabolismo,
Proliferación Celular,
Colesterol/sangre,
Duodeno/cirugía,
Acido Graso Sintasa Tipo I/metabolismo,
Ácidos Grasos/sangre,
Hígado Graso/metabolismo,
Hígado Graso/fisiopatología,
Derivación Gástrica/métodos,
Enfermedades Hipotalámicas/metabolismo,
Enfermedades Hipotalámicas/fisiopatología,
Enfermedades Hipotalámicas/cirugía,
Insulina/22063,
Resistencia a la Insulina,
Islotes Pancreáticos/citología,
Islotes Pancreáticos/metabolismo,
Islotes Pancreáticos/fisiopatología,
Yeyuno/cirugía,
Lipogénesis/genética,
Hígado/metabolismo,
Hígado/patología,
Obesidad/metabolismo,
Obesidad/fisiopatología,
Obesidad/cirugía,
Páncreas/metabolismo,
Páncreas/patología,
Distribución Aleatoria,
Ratas Wistar,
Reproducibilidad de los Resultados,
Factores de Tiempo,
Triglicéridos/sangre
Cannabinoid type 1 receptor (CB1R) inhibition tends to be one of the promising strategies for the treatment of obesity and other related metabolic disorders. Although CB1R inhibition may cause adverse psychiatric effects including depression and anxiety, the investigation of the role of peripheral CB1R o...
Glucemia/efectos de los fármacos,
Peso Corporal/efectos de los fármacos,
Canales de Calcio/efectos de los fármacos,
Canales de Calcio/metabolismo,
Canales de Calcio Tipo L/efectos de los fármacos,
Canales de Calcio Tipo L/metabolismo,
Antagonistas de Receptores de Cannabinoides/farmacología,
Dieta Alta en Grasa/efectos adversos,
Intolerancia a la Glucosa/etiología,
Resistencia a la Insulina,
Ratones Endogámicos C57BL,
Modelos Animales,
Músculo Esquelético/efectos de los fármacos,
Músculo Esquelético/metabolismo,
Obesidad/etiología,
Piperidinas/farmacología,
Pirazoles/farmacología,
Receptor Cannabinoide CB1/antagonistas & inhibidores,
Receptor Cannabinoide CB1/fisiología
ABSTRACT Recent studies have shown a role of intestinal microbiota in obesity. The consumption of antibiotics in the last 70 years has led to changes in intestinal microbiota, which has led to weight gain and body fat accumulation. To evaluate the possibility of weight gain induced by antibiotics and the...
INTRODUCTION: The prevalence of obesity in children and adults has increased worldwide exponentially over the past two decades, becoming an important issue of global public health. OBJECTIVE: To describe the growth and nutritional status of adolescents of public schools. METHODS: Epidemiological, cross-s...
Resumo: O objetivo do estudo foi investigar a associação entre o consumo alimentar inadequado de micronutrientes e indicadores de obesidade geral e abdominal. Análise transversal, da segunda onda do estudo longitudinal EpiFloripa Adultos, incluindo 1.222 indivíduos de 22-63 anos, residentes em Floria...
Factores de Edad,
Avitaminosis/complicaciones,
Índice de Masa Corporal,
Brasil/epidemiología,
Estudios Transversales,
Dieta/efectos adversos,
Encuestas sobre Dietas/estadística & datos numéricos,
Ingestión de Energía,
Modelos Lineales,
Persona de Mediana Edad,
Obesidad/epidemiología,
Obesidad/etiología,
Obesidad/metabolismo,
Prevalencia,
Valores de Referencia,
Factores Sexuales,
Factores Socioeconómicos,
Oligoelementos/deficiencia,
Oligoelementos/metabolismo,
Vitaminas/metabolismo,
Circunferencia de la Cintura/fisiología
