ABSTRACT Purpose: To establish whether the citrate concentration in the seminal fluid ([CITRATE]) measured by means of high-resolution nuclear magnetic resonance spectroscopy (1HNMRS) is superior to the serum prostate-specific antigen (PSA) concentration in detecting of clinically significant prostate c...
Biomarcadores de Tumor/análisis,
Biopsia,
Ácido Cítrico/análisis,
Persona de Mediana Edad,
Antígeno Prostático Específico/sangre,
Hiperplasia Prostática/sangre,
Hiperplasia Prostática/diagnóstico,
Neoplasias de la Próstata/sangre,
Neoplasias de la Próstata/diagnóstico,
Neoplasias de la Próstata/patología,
Reproducibilidad de los Resultados,
Medición de Riesgo,
Semen/química,
Sensibilidad y Especificidad,
Estadísticas no Paramétricas
SUMMARY Breast cancer (BC) is one of the primary health problems worldwide. As the most common cancer in women in the world and in Brasil, behind only non-melanoma skin cancer, this neoplasm corresponds to approximately 28% of new cases per year in the country. BC also affects men, although the incidence...
Abstract Introduction: Cell division cycle-7 protein is a serine/threonine kinase that has a basic role in cell cycle regulation and is a potential prognostic or therapeutic target in some human cancers. Objectives: This study investigated the expression of cell division cycle-7 protein in benign and m...
Adenoma Pleomórfico/patología,
Biomarcadores de Tumor/análisis,
Carcinoma Adenoide Quístico/patología,
Carcinoma Mucoepidermoide/patología,
Estudios de Casos y Controles,
Proteínas de Ciclo Celular/análisis,
Diferenciación Celular,
Estudios Transversales,
Inmunohistoquímica,
Pronóstico,
Proteínas Serina-Treonina Quinasas/análisis,
Valores de Referencia,
Estudios Retrospectivos,
Neoplasias de las Glándulas Salivales/patología
SUMMARY OBJECTIVE: This study aims to evaluate the sleep of subjects with polycystic ovary syndrome (PCOS), with and without hyperandrogenism, in comparison with a healthy control group and examine the effects of hyperandrogenism and obesity on sleep parameters. METHODS: A total of 44 volunteers were r...
Wu, Xue-Liang;
Wang, Yuan-Yuan;
Wang, Li-Kun;
Xue, Jun;
Yang, Dong-Dong;
Qu, Ming;
Wang, Chen-Yu;
Guo, Fei;
Yang, Rui-Min;
Liu, Bo.
SUMMARY BACKGROUND: This study aims to investigate the expression of Id-1 in human colorectal adenocarcinoma tissues and explore its correlation with the clinical pathological parameters of colorectal cancer. METHODS: The Id-1 mRNA and protein expression levels of 50 specimens of normal colorectal tiss...
ABSTRACT BACKGROUND: There are cases of colorectal tumors that, although small, show more aggressive evolution than large tumors. This motivated us to study whether there are any proteins capable of alerting about these changes. The aim here was to correlate the immunoexpression of the TS, p53, COX2, E...
Adenocarcinoma/mortalidad,
Adenocarcinoma/patología,
Biomarcadores de Tumor/análisis,
Neoplasias Colorrectales/mortalidad,
Neoplasias Colorrectales/patología,
Ciclooxigenasa 2/análisis,
Proteínas de Unión al ADN/análisis,
Receptores ErbB/análisis,
Inmunohistoquímica,
Estimación de Kaplan-Meier,
Estudios Longitudinales,
Homólogo 1 de la Proteína MutL/análisis,
Estadificación de Neoplasias,
Modelos de Riesgos Proporcionales,
Valores de Referencia,
Estudios Retrospectivos,
Timidilato Sintasa/análisis,
Análisis de Matrices Tisulares,
Proteína p53 Supresora de Tumor/análisis
Apoptosis,
Biomarcadores de Tumor/análisis,
Carcinoma Basocelular/patología,
Proliferación Celular,
Estudios Transversales,
Epidermis/patología,
Inmunohistoquímica,
Antígeno Ki-67/análisis,
Análisis Multivariante,
Subunidad p50 de NF-kappa B/análisis,
Neoplasias Cutáneas/patología,
Survivin/análisis,
Proteína p53 Supresora de Tumor/análisis
Abstract SOX2 is a transcription factor related to the maintenance of stem cells in a pluripotent state. Podoplanin is a type of transmembrane sialoglycoprotein, which plays an important role in tumor progression and metastasis. This study aims to determine association of SOX2 and podoplanin expression i...
Biomarcadores de Tumor/análisis,
Carcinoma de Células Escamosas/patología,
Progresión de la Enfermedad,
Inmunohistoquímica,
Glicoproteínas de Membrana/análisis,
Neoplasias de la Boca/patología,
Clasificación del Tumor,
Estadificación de Neoplasias,
Valores de Referencia,
Factores de Transcripción SOXB1/análisis,
Estadísticas no Paramétricas,
Factores de Tiempo
BACKGROUND: Non-small cell lung cancer (NSCLC) is one of the leading causes of death in the world. NSCLC diagnosed at an early stage can be highly curable with a positive prognosis, but biomarker limitations make it difficult to diagnose lung cancer at an early stage. To identify biomarkers for lung canc...
Antígenos de Diferenciación/genética,
Carcinoma de Pulmón de Células no Pequeñas/genética,
Proliferación Celular/genética,
Regulación hacia Abajo/genética,
Neoplasias Pulmonares/genética,
Factor de Transcripción AP-2/genética,
Biomarcadores de Tumor/análisis,
Genes Supresores de Tumor/fisiología,
ARN Mensajero/análisis,
ARN Interferente Pequeño/análisis,
Línea Celular Tumoral,
Regulación Neoplásica de la Expresión Génica
O câncer de boca ocupa uma posição de destaque em relação ao número total de casos registrados no Brasil. A displasia epitelial (DE) oral é um achado histopatológico associado a um risco aumentado de transformação maligna do epitélio oral. A falha nos mecanismos de sinalização celular, no co...
