ABSTRACT Objectives: Determine immunohistochemical expression of Phosphatase and tensin homolog (PTEN), Phosphatidylinositol 3 kinase (PI3K), Cycloxygenase-2 (COX2) and one proliferation marker (Ki67) in colorectal polyps and correlate with clinical and pathological data in search of carcinogenic pathwa...
The inducible inflammatory enzyme cycloxigenase-2 is up-regulated in cancer, and favors tumor progression. Cycloxigenase-2 is encoded by the prostaglandin-endoperoxide synthase 2 (PTGS2) gene, which presents sequence variations in the promoter region (PR) and in the 3′-untranslated region (3′...
Línea Celular Tumoral,
Ciclooxigenasa 2/genética,
Ciclooxigenasa 2/metabolismo,
Regulación Neoplásica de la Expresión Génica/genética,
Genotipo,
Haplotipos,
Luciferasas/metabolismo,
Células MCF-7,
Mutagénesis Sitio-Dirigida,
Polimorfismo de Nucleótido Simple,
Regulación hacia Arriba
Abstract The cyclooxygenase (COX) exists in two main isoforms, COX-1 and COX-2, which are present in the renal system to ensure its homeostasis. However, in different clinical situations, these enzymes can play a physiologic role in maintaining the integrity of this organ, and also be associated with the...
ABSTRACT Background: The colorectal neoplasm is the fourth most common malignancy among males and the third among females. In the Western world is estimated that 5% of the population will develop it, making this disease a major public health problem. Aim: To analyze the prevalence of the polymorphism...
microRNA (miR)-142-3p is implicated in malignancy and has been identified as a biomarker for aggressive and recurrent lung adenocarcinomas. This study aimed to evaluate the inhibitory effect of miR-142-3p on apoptosis and inflammation induced by bleomycin in MLE-12 cells. MLE-12 cells were first transfec...
ABSTRACT Background: Healing is an innate biological phenomenon, and carcinogenesis acquired, but with common humoral and cellular elements. Carcinogenesis interferes negatively in healing. Aim: To evaluate the histological changes in laparotomy scars of healthy Balb/c mice and with an Ehrlich tumor i...
BACKGROUND: Wnt-5a is a member of the WNT family of secreted lipoglycoproteins, whose expression increases during development; moreover, Wnt-5a plays a key role in synaptic structure and function in the adult nervous system. However, the mechanism underlying these effects is still elusive. MicroRNAs (miR...
Ciclooxigenasa 2/análisis,
Hipocampo/enzimología,
MicroARNs/fisiología,
Neuronas/enzimología,
Proteínas Wnt/fisiología,
Hipocampo/química,
Neuronas/química,
Western Blotting,
Células Cultivadas,
Regulación hacia Abajo,
Expresión Génica,
Perfilación de la Expresión Génica,
Marcación de Gen,
Plasticidad Neuronal,
Ratas Sprague-Dawley,
Reacción en Cadena en Tiempo Real de la Polimerasa,
Proteína Wnt-5a
Background: The effectiveness of low-level laser therapy in muscle regeneration is still not well known. Objective: To investigate the effects of laser irradiation during muscle healing. Method: For this purpose, 63 rats were distributed to 3 groups: non-irradiated control group (CG); group irradiated at...
BACKGROUND: Ligularia fischeri (common name Gomchwi) is known for its pharmaceutical properties and used in the treatment of jaundice, scarlet-fever, rheumatoidal arthritis, and hepatic diseases; however, little is known about its anti-inflammatory effect. In this study the influence of blanching and pan...
Asteraceae/química,
Culinaria/métodos,
Macrófagos/efectos de los fármacos,
Óxido Nítrico/biosíntesis,
Óxido Nítrico Sintasa de Tipo II/metabolismo,
Preparaciones de Plantas/farmacología,
Antiinflamatorios/farmacología,
Asteraceae/clasificación,
Ciclooxigenasa 2/análisis,
Ciclooxigenasa 2/metabolismo,
Dinoprostona/análisis,
Dinoprostona/biosíntesis,
Macrófagos/fisiología,
Ácido Quínico/análogos & derivados,
Ácido Quínico/análisis,
Ácido Quínico/clasificación,
ARN Mensajero/efectos de los fármacos,
ARN Mensajero/metabolismo,
Supervivencia Celular,
Cromatografía Líquida de Alta Presión,
Calor,
Lipopolisacáridos,
Células RAW 264.7
BACKGROUND: The root of Angelica sinensis (AS), also known as "Dang-gui," was a popular herbal medicine widely used in the treatment of gynecological diseases in China, Korea, and Japan for a long time. This study aimed to determine the effects of ethyl acetate fraction from Angelica sinensis (EAAS) on t...
Angelica sinensis/química,
Artritis Reumatoide/metabolismo,
Bolsa Sinovial/citología,
Proliferación Celular/efectos de los fármacos,
Fibroblastos/efectos de los fármacos,
Mediadores de Inflamación/metabolismo,
Artritis Reumatoide/patología,
Ciclooxigenasa 2/efectos de los fármacos,
Ciclooxigenasa 2/metabolismo,
Dinoprostona/metabolismo,
Fibroblastos/citología,
Fibroblastos/metabolismo,
Interleucina-1beta/farmacología,
Articulación de la Rodilla/citología,
Metaloproteinasas de la Matriz/efectos de los fármacos,
Metaloproteinasas de la Matriz/metabolismo,
FN-kappa B/efectos de los fármacos,
Extractos Vegetales/farmacología,
Raíces de Plantas/química,
Proteínas Recombinantes/farmacología,
Acetatos,
Ensayo de Inmunoadsorción Enzimática,
Citometría de Flujo,
Medicina de Hierbas,
Immunoblotting,
Cultivo Primario de Células,
Reacción en Cadena en Tiempo Real de la Polimerasa
