ABSTRACT Inflammatory bowel disease comprises two distinct conditions - Crohn's disease and ulcerative colitis - which can be treated with immunomodulators. A non-neglectable proportion of these patients will need biologic therapy, and many patients under biologic treatment will experience either primary...
ABSTRACT BACKGROUND: Patients with inflammatory bowel disease (IBD) vaccinated for hepatitis B have a low success rate in achieving protective antibody levels. The main factors suggested for this are IBD itself and the use of immunosuppressive drugs. OBJECTIVE: To evaluate the concentration of anti-H...
Colitis Ulcerosa/tratamiento farmacológico,
Colitis Ulcerosa/inmunología,
Enfermedad de Crohn/tratamiento farmacológico,
Enfermedad de Crohn/inmunología,
Hepatitis B/diagnóstico,
Hepatitis B/inmunología,
Hepatitis B/prevención & control,
Anticuerpos contra la Hepatitis B/sangre,
Antígenos de Superficie de la Hepatitis B/inmunología,
Vacunas contra Hepatitis B/administración & dosificación,
Vacunas contra Hepatitis B/inmunología,
Virus de la Hepatitis B/inmunología,
Inmunosupresores/uso terapéutico,
Persona de Mediana Edad,
Estudios Prospectivos,
Investigación Cualitativa,
Seroconversión
Xue, Nan-nan;
He, Miao;
Li, Yue;
Wu, Jun-zhu;
Du, Wen-wen;
Wu, Xiu-mei;
Yang, Zi-zhong;
Zhang, Cheng-gui;
Li, Qi-yan;
Xiao, Huai.
Abstract Purpose: To investigate the mechanism of Periplaneta americana extract promoting intestinal mucosal repair of OXZ-induced colitis in rat. Methods: All experiments used an equal number of male and female SD rats (n=48). We injected OXZ into the colon to induce UC rat model. To determine the opt...
ABSTRACT BACKGROUND: The introduction of anti-TNF agents represented a landmark in the management of both Crohn's disease (CD) and ulcerative colitis (UC), with improved efficacy and safety when compared with conventional treatment. However, significant challenges still exist in Latin America to facili...
Perin, Ramir Luan;
Damião, Aderson Omar Mourão Cintra;
Flores, Cristina;
Ludvig, Juliano Coelho;
Magro, Daniéla Oliveira;
Miranda, Eron Fábio;
Moraes, Antonio Carlos de;
Nones, Rodrigo Bremer;
Teixeira, Fábio Vieira;
Zeroncio, Marco;
Kotze, Paulo Gustavo.
ABSTRACT BACKGROUND: There is scarce data regarding efficacy and safety of vedolizumab in inflammatory bowel diseases in Latin America. OBJECTIVE: To describe the first observational real-world experience with vedolizumab in Latin American inflammatory bowel diseases patients. METHODS: Retrospectiv...
Teixeira, Fabio Vieira;
Vilela, Eduardo Garcia;
Damião, Aderson Omar Mourão Cintra;
Vieira, Andrea;
Albuquerque, Idblan Carvalho De;
Parente, José Miguel Luz;
Chebli, Júlio Maria Fonseca;
Ambrogini Junior, Orlando;
Hossne, Rogerio Saad;
Miszputen, Sender Jankiel.
The Guidelines Project, an initiative of the Brazilian Medical Association, aims to combine information from the medical field in order to standardize producers to assist the reasoning and decision-making of doctors. The information provided through this project must be assessed and criticized by the phy...
Abstract Purpose To examine the therapeutic effect of external adenosine on an acetic acid-induced acute ulcerative colitis model in rats. Methods Thirty male mature rats were divided into three groups as control, acute colitis (AC) and AC+adenosine group (AC+AD). AC was induced by rectal administrat...
Ácido Acético,
Enfermedad Aguda,
Adenosina/uso terapéutico,
Antiinflamatorios/uso terapéutico,
Proteína C-Reactiva/análisis,
Colitis Ulcerosa/inducido químicamente,
Colitis Ulcerosa/tratamiento farmacológico,
Colitis Ulcerosa/patología,
Colon/patología,
Ensayo de Inmunoadsorción Enzimática,
Inmunohistoquímica,
Malondialdehído/sangre,
FN-kappa B/análisis,
Ratas Sprague-Dawley,
Recto/patología,
Valores de Referencia,
Reproducibilidad de los Resultados,
Componente Amiloide P Sérico/análisis,
Sustancias Reactivas al Ácido Tiobarbitúrico,
Factores de Tiempo,
Resultado del Tratamiento,
Factor de Necrosis Tumoral alfa/análisis
Quera, Rodrigo;
Moreno, Mauricio;
Simian, Daniela;
Ibáñez, Patricio;
Lubascher, Jaime;
Figueroa, Carolina;
Flores, Lilian;
Kronberg, Udo;
Pizarro, Gonzalo;
Fluxá, Daniela.
Background: Primary non-response and secondary loss of response (LOR) are significant problems of biological therapy for inflammatory bowel disease (IBD). Therapeutic drug monitoring (TDM) in IBD patients receiving these drugs can improve outcomes. Aim: To measure serum infliximab levels and anti-inflix...
Colitis Ulcerosa/tratamiento farmacológico,
Enfermedad de Crohn/tratamiento farmacológico,
Monitoreo de Drogas/métodos,
Fármacos Gastrointestinales/uso terapéutico,
Infliximab/uso terapéutico,
Colitis Ulcerosa/diagnóstico por imagen,
Colonoscopía,
Enfermedad de Crohn/diagnóstico por imagen,
Ensayo de Inmunoadsorción Enzimática,
Fármacos Gastrointestinales/sangre,
Infliximab/sangre,
Estudios Prospectivos,
Valores de Referencia,
Reproducibilidad de los Resultados,
Índice de Severidad de la Enfermedad,
Estadísticas no Paramétricas,
Resultado del Tratamiento
ABSTRACT Janus kinases inhibitors have already been incorporated into the management of immune-mediated diseases, such as rheumatoid arthritis, and are being investigated for the treatment of psoriasis and inflammatory bowel diseases, both ulcerative colitis and Crohn's disease. Tofacitinib is an oral sm...
