Abstract Purpose: To investigate the effects of cyclosporine A on renal ischemia-reperfusion injury during transient hyperglycemia in rats. Methods: In a model of ischemia-reperfusion-induced renal injury and transiently induced hyperglycemia by intraperitoneal injection of glucose, 2.5 g.kg-1, Wistar...
Abstract Introduction: Ischemic postconditioning is a method that shows evidence of efficacy in minimizing reperfusion injury; however, its effectiveness in preventing injuries in distant organs is still unknown, especially in those who have undergone mesenteric ischemia and reperfusion. Objective: To ...
ABSTRACT PURPOSE: To determine whether Toll-like receptor 7 (TLR7) is the potential targets of prevention or progression in the renal ischemia/reperfusion (I/R) injury of STZ-induced diabetic rats. METHODS: Thirty six Sprague-Dawley rats were randomly arranged to the nondiabetic (ND) or diabetic group ...
ABSTRACT PURPOSE: To investigate the protective effect of β-myrcene (MYR) on oxidative and histological damage in mice heart tissue caused global cerebral ischemia/reperfusion (IR) in C57BL/J6 mice. METHODS: Animals(n=40) were randomly divided into four groups: (1)control, (2)IR, (3)MYR and (4)MYR...
ABSTRACT PURPOSE: To evaluate the effect of Otostegia persica (O. persica) extract on renal damage induced by ischemia/reperfusion (I/R) in diabetic rats. METHODS: Forty-eight rats were subjected to right nephrectomy; then, they were allocated into six groups: Sham; Diabetic sham; I/R; Diabetic I/R; I/...
El éxito de la ciclosporina A (CsA) como inmunosupresor se ha visto limitado por su nefrotoxicidad. Estudiamos el efecto de la CsA sobre el daño renal isquémico. Ratas Sprague-Dowley monorrenas fueron sometidas a 60 minutos de clampeo de la arteria renal derecha. La mortalidad por insuficiencia renal ...
Diversas sustancias han mostrado efectividad en la protección del daño renal por isquemia-reperfusión. La inhibición de la xantínoxidasa (XO) por alopurinol (ALO) ha sido una de las más estudiadas. Previamente, mostramos el efecto protector de la Moclobemida (MOC), un inhibidor reversible de la mon...