Sun, Ying;
Wang, Wei;
Tang, Yuxiao;
Wang, Daping;
Li, Liang;
Na, Min;
Jiang, Guantong;
Li, Qian;
Chen, Shulin;
Zhou, Jin.
BACKGROUND: Circulating RNA (circRNA) regulates various bioactivities in cells. A better understanding of the exosomal circRNA can provide novel insights into the pathogenesis and treatment of Graves' disease (GD). We aimed to profile the differentially expressed circRNAs (DEcRs) in plasma exosomes of pa...
Li, Musheng;
Zhao, Junhong;
Cao, Meiwan;
Liu, Ruitao;
Chen, Guanhua;
Li, Songyu;
Xie, Yuanwen;
Xie, Jing;
Cheng, Yang;
Huang, Ling;
Su, Mingmin;
Xu, Yuxin;
Zheng, Mingyue;
Zou, Kejian;
Geng, Lanlan;
Xu, Wanfu;
Gong, Sitang.
BACKGROUND: Mast cells (MCs) have been found to play a critical role during development of inflammatory bowel disease (IBD) that characterized by dysregulation of inflammation and impaired intestinal barrier function. However, the function of MCs in IBD remains to be fully elucidated. RESULTS: In our stu...
Células Epiteliales/metabolismo,
Mucosa Intestinal/metabolismo,
Mastocitos/metabolismo,
MicroARNs/metabolismo,
Células CACO-2/citología,
Claudinas/metabolismo,
Exosomas/metabolismo,
Enfermedades Inflamatorias del Intestino/metabolismo,
Ocludina/metabolismo,
Proteína de la Zonula Occludens-1/metabolismo,
Células Cultivadas,
Biología Computacional,
Permeabilidad,
Análisis de Matrices Tisulares
Leishmania infantum chagasi é o principal agente etiológico da leishmaniose visceral na América Latina, uma doença letal que aflige centenas de milhares de pessoas em todo o mundo a cada ano. Estudos prévios mostraram que o parasita secreta microvesículas conhecidas como exossomos, que prolongam e ...
Exosomes, a kind of extracellular vesicle, are promising therapeutic agents for spinal cord injury (SCI). This article aimed to investigate effects of exosomes secreted from miRNA-29b-modified bone marrow mesenchymal stem cells (BMSCs) on SCI. Exosomes were extracted from BMSCs transfected with miRNA-29b...
Tapia-Castillo, Alejandra;
Valdivia P, Carolina;
Campino J, Carmen;
Allende, Fidel;
Solari, Sandra;
Ortiz, David;
Barros, Eric;
Vecchiola, Andrea;
Baudrand, Rene;
Fardella, Carlos;
Carvajal M, Cristian.
About 15% of the essential hypertensive patients would have a low activity of the 11βHSD2 enzyme, which inactivates cortisol (F) to cortisone (E). Gene expression can be negatively regulated by miRNA. Urinary exosomes and their specific content (miRNA/proteins) represent a valuable tool as a biomarker f...
Zhang, S;
Zhang, Y;
Qu, J;
Che, X;
Fan, Y;
Hou, K;
Guo, T;
Deng, G;
Song, N;
Li, C;
Wan, X;
Qu, X;
Liu, Y.
Cetuximab is widely used in patients with metastatic colon cancer expressing wildtype KRAS. However, acquired drug resistance limits its clinical efficacy. Exosomes are nanosized vesicles secreted by various cell types. Tumor cell-derived exosomes participate in many biological processes, including tumor...
Análisis de Varianza,
Antineoplásicos Inmunológicos/farmacología,
Western Blotting,
Células CACO-2,
Línea Celular Tumoral,
Cetuximab/farmacología,
Neoplasias del Colon/tratamiento farmacológico,
Exosomas/efectos de los fármacos,
Fosfohidrolasa PTEN/efectos de los fármacos,
Proteínas Proto-Oncogénicas c-akt/efectos de los fármacos,
Sales de Tetrazolio,
Factores de Tiempo
La posibilidad de que los exosomas funcionen como una nueva forma de comunicación intercelular para establecer y mantener circuitos cerebrales está comenzando a ser explorada. Los exosomas son liberados desde células e interactúan con otras células receptoras para mediar cambios fisiológicos. Todas...
Los exosomas son vesículas membranosas extracelulares esenciales en la comunicación intercelular a larga distancia, viajan en los fluidos corporales y entregan mensajes moleculares dirigidos a la mayoría de las células de todo el organismo. La liberación de mensajes vía exosomas ocurre en forma de ...
O carcinoma epidermóide (CE) de língua representa uma das lesões malignas mais comuns em cavidade oral e caracteriza-se por apresentar um comportamento localmente invasivo e agressivo. Os exossomos são responsáveis pela comunicação célula-célula e podem influenciar na progressão tumoral, metás...
