Hepatocellular carcinoma (HCC) is the second cause of cancer-related death in the world and is the main cause of death in cirrhotic patients. Unfortunately, the incidence of HCC has grown significantly in the last decade. Curative treatments such as surgery, liver transplantation or percutaneous ablation...
Noncolorectal gastrointestinal (GI) malignancies are among the most frequently diagnosed cancers. Despite the undeniable progress in systemic treatments in recent decades, further improvements using cytotoxic chemotherapy seem unlikely. In this setting, recent discoveries regarding the mechanism underlyi...
Technological developments have allowed improvements in radiotherapy delivery, with higher precision and better sparing of normal tissue. For many years, it has been well known that ionizing radiation has not only local action but also systemic effects by triggering many molecular signaling pathways. The...
Apoptosis/inmunología,
Apoptosis/efectos de la radiación,
Muerte Celular/efectos de la radiación,
Relación Dosis-Respuesta en la Radiación,
Sistema Inmunológico/efectos de la radiación,
Inmunoterapia/métodos,
Inmunoterapia/tendencias,
Necrosis/etiología,
Neoplasias/inmunología,
Neoplasias/radioterapia,
Radiación Ionizante,
Radioterapia/efectos adversos,
Radioterapia/tendencias
ABSTRACT Objective: To investigate the correlation between total lymphocyte and CD3+ T cell counts in peripheral blood in renal transplant patients treated with anti-thymocyte globulin, and discuss related outcomes. Methods: A single-center, retrospective study involving 226 patients submitted to kidne...
Anticuerpos Monoclonales/uso terapéutico,
Complejo CD3,
Citometría de Flujo/métodos,
Rechazo de Injerto/terapia,
Inmunoterapia/métodos,
Isoanticuerpos/uso terapéutico,
Trasplante de Riñón,
Recuento de Linfocitos,
Persona de Mediana Edad,
Monitorización Inmunológica/instrumentación,
Estudios Retrospectivos,
Análisis de Supervivencia,
Linfocitos T/inmunología,
Timocitos/inmunología,
Receptores de Trasplantes
The immunologic landscape of tumors has been continuously unveiled, providing a new look at the interactions between cancer cells and the immune system. Emerging tumor cells are constantly eliminated by the immune system, but some cells establish a long-term equilibrium phase leading to tumor immunoediti...
Antígenos de Neoplasias/análisis,
Vacunas contra el Cáncer/uso terapéutico,
Transformación Celular Neoplásica,
Terapia Combinada,
Terapia Genética,
Inmunoterapia/métodos,
Mutación,
Neoplasias/genética,
Neoplasias/inmunología,
Neoplasias/terapia,
Escape del Tumor/inmunología,
Microambiente Tumoral/inmunología
While cancer immunotherapy has gained much deserved attention in recent years, many areas regarding the optimization of such modalities remain unexplored, including the development of novel approaches and the strategic combination of therapies that target multiple aspects of the cancer-immunity cycle. Ou...
Hepner, Adriana;
Salgues, Alessandra;
Anjos, Carlos A. dos;
Sahade, Marina;
Camargo, Veridiana P;
Garicochea, Bernardo;
Shoushtari, Alexander N;
Postow, Michael A;
Fernandes, Gustavo S;
Munhoz, Rodrigo R.
Summary Following decades of relative ostracism, advances in the treatment of melanoma have brought a new reality for patients, physicians and researchers. While antibodies targeting molecules involved in the modulation of the interaction between melanoma and immune cells changed the meaning of the term ...
Abstract: The stimulation of the immune system, in order to generate an attack against cancer cells, similarly to that which occurs in infectious disease, has long been matter of interest in oncology; however, only limited success has been achieved, with different treatment strategies tested in recent ye...
Anticuerpos Monoclonales/uso terapéutico,
Anticuerpos Monoclonales Humanizados/uso terapéutico,
Antineoplásicos Inmunológicos/uso terapéutico,
Protocolos de Quimioterapia Combinada Antineoplásica,
Antígeno CTLA-4/antagonistas & inhibidores,
Inmunoterapia/métodos,
Ipilimumab/uso terapéutico,
Melanoma/tratamiento farmacológico,
Melanoma/inmunología,
Neoplasias/tratamiento farmacológico,
Neoplasias/inmunología,
Nivolumab,
Receptor de Muerte Celular Programada 1/antagonistas & inhibidores,
Resultado del Tratamiento
A evolução do tratamento oncológico resultou no desenvolvimento de fármacos
altamente eficazes. No entanto, os efeitos colaterais da terapia antitumoral ainda são
frequentes e, muitas vezes, limitantes. Entre os efeitos adversos possíveis, a cardiotoxicidade
representa um grupo importante de manife...
Quimioterapia/métodos,
Cardiotoxicidad/complicaciones,
Enfermedades Cardiovasculares/terapia,
Neoplasias/terapia,
Disfunción Ventricular,
Volumen Sistólico,
Antraciclinas/uso terapéutico,
Paclitaxel/uso terapéutico,
Inmunoterapia/métodos,
Factores de Riesgo,
Exposición a la Radiación/efectos adversos
Abstract The immune system interacts closely with tumors during the disease development and progression to metastasis. The complex communication between the immune system and the tumor cells can prevent or promote tumor growth. New therapeutic approaches harnessing protective immunological mechanisms hav...
