Results: 45

Polyclonal anti T-lymphocyte antibody therapy monitoring in kidney transplant recipients: comparison of CD3+ T cell and total lymphocyte counts

Einstein (Säo Paulo); 16 (4), 2018
ABSTRACT Objective: To investigate the correlation between total lymphocyte and CD3+ T cell counts in peripheral blood in renal transplant patients treated with anti-thymocyte globulin, and discuss related outcomes. Methods: A single-center, retrospective study involving 226 patients submitted to kidne...

Dendritic cells and their relation to apical peridontitis

Braz. oral res. (Online); 32 (supl.1), 2018
Abstract: The purpose of this manuscript was to re-discuss apical periodontitis, apical biofilm, and its possible relationship with dendritic cells (DC). DCs are potent regulators of the immune system and their function is divided into three categories that involve the presentation of antigens: the prese...

Impaired T cell-mediated hepatitis in peroxisome proliferator activated receptor alpha (PPARα)-deficient mice

Biol. Res; 51 (), 2018
Abstract Background Peroxisome proliferator activated receptor alpha (PPARα), a regulator of enzymes involved in β oxidation, has been reported to influence lymphocyte activation. The purpose of this study was to determine whether PPARα plays a role in T cell-mediated hepatitis induced by...

Cut-off value for absolute lymphocytes as an alternative for the immunophenotypic analysis of CD3+ T cells in the monitoring of immunosuppressive therapy with thymoglobulin

J. bras. nefrol; 39 (2), 2017
Abstract Introduction: Immunosuppression of T lymphocytes is required for preventing acute rejection after transplantation and for the treatment of chronic autoimmune and inflammatory diseases. The laboratory monitoring for this therapy is the measurement of T cells by immunophenotyping, aiming the targ...

Conversion to Mycophenolate Mofetil Monotherapy in Liver Recipients: Calcineurin Inhibitor Levels are Key

Ann. hepatol; 16 (1), 2017
Abstract: The use of calcineurin inhibitors (CNI) after liver transplantation is associated with post-transplant nephrotoxicity. Conversion to mycophenolate mofetil (MMF) monotherapy improves renal function, but is related to graft rejection in some recipients. Our aim was to identify variables associate...

Vacunas terapéuticas antitumorales basadas en células dendríticas
Dendritic cell-based therapeutic cancer vaccines

Medicina (B.Aires); 76 (5), 2016
En los últimos años la inmunoterapia ha revolucionado el tratamiento de pacientes con cáncer avanzado. El mayor conocimiento de la biología tumoral y de la inmunología ha permitido desarrollar tratamientos racionales manipulando el sistema inmunitario con importante impacto clínico. Entre otras est...

Total knee replacement induces peripheral blood lymphocytes apoptosis and it is not prevented by regional anesthesia - a randomized study

Rev. bras. anestesiol; 66 (2), 2016
ABSTRACT BACKGROUND: Among the many changes caused by a surgical insult one of the least studied is postoperative immunosuppression. This phenomenon is an important cause of infectious complications of surgery such as surgical site infection or hospital acquired pneumonia. One of the mechanisms leading...

Cytokine profile and lymphocyte subsets in type 2 diabetes

Braz. j. med. biol. res; 49 (4), 2016
Type 2 diabetes mellitus (T2D) is a metabolic disease with inflammation as an important pathogenic background. However, the pattern of immune cell subsets and the cytokine profile associated with development of T2D are unclear. The objective of this study was to evaluate different components of the immun...

Imunopatologia da encefalomielite auto-imune experimental murina mediada por linfócitos T

HU rev; 34 (3), 2008
A Esclerose Múltipla é uma doença crônica, inflamatória e desmielinizante do Sistema Nervoso Central. Embora a sua etiologia seja, ainda, desconhecida, supõe-se tratar-se de uma doença auto-imune mediada por células T CD4+ com perfil Th1. A Encefalomielite Auto-imune Experimental (EAE) é um mode...

Presente y futuro de la terapia inmunosupresora
[Present and future of immunosuppressive therapy]

Medicina (B.Aires); 60 (1), 2000
Immunosuppressive drugs make possible the acceptance of organ allografts among individuals with differences in Major Histocompatibility Antigens (HLA). Transplantation of vital organs prolongs the survival of patients with terminal diseases, and this procedure has become a routine practice in the clinic,...